Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P23458 | JAK1 | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) … | Homo sapiens (Human) | 1154 aa |
Protein Details: P23458 (JAK1)
Protein Information
| Accession | P23458 |
|---|---|
| Protein Names | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) |
| Gene Symbol | JAK1 |
| Organism | Homo sapiens (Human) |
| Length | 1154 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 26111759 29575903 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MQYLNIKEDC11NAMAFCAKMR21SSKKTEVNLE31APEPGVEVIF41YLSDREPLRL
51-10051GSGEYTAEEL61CIRAAQACRI71SPLCHNLFAL81YDENTKLWYA91PNRTITVDDK
101-150101MSLRLHYRMR111FYFTNWHGTN121DNEQSVWRHS131PKKQKNGYEK141KKIPDATPLL
151-200151DASSLEYLFA161QGQYDLVKCL171APIRDPKTEQ181DGHDIENECL191GMAVLAISHY
201-250201AMMKKMQLPE211LPKDISYKRY221IPETLNKSIR231QRNLLTRMRI241NNVFKDFLKE
251-300251FNNKTICDSS261VSTHDLKVKY271LATLETLTKH281YGAEIFETSM291LLISSENEMN
301-350301WFHSNDGGNV311LYYEVMVTGN321LGIQWRHKPN331VVSVEKEKNK341LKRKKLENKH
351-400351KKDEEKNKIR361EEWNNFSYFP371EITHIVIKES381VVSINKQDNK391KMELKLSSHE
401-450401EALSFVSLVD411GYFRLTADAH421HYLCTDVAPP431LIVHNIQNGC441HGPICTEYAI
451-500451NKLRQEGSEE461GMYVLRWSCT471DFDNILMTVT481CFEKSEQVQG491AQKQFKNFQI
501-550501EVQKGRYSLH511GSDRSFPSLG521DLMSHLKKQI531LRTDNISFML541KRCCQPKPRE
551-600551ISNLLVATKK561AQEWQPVYPM571SQLSFDRILK581KDLVQGEHLG591RGTRTHIYSG
601-650601TLMDYKDDEG611TSEEKKIKVI621LKVLDPSHRD631ISLAFFEAAS641MMRQVSHKHI
651-700651VYLYGVCVRD661VENIMVEEFV671EGGPLDLFMH681RKSDVLTTPW691KFKVAKQLAS
701-750701ALSYLEDKDL711VHGNVCTKNL721LLAREGIDSE731CGPFIKLSDP741GIPITVLSRQ
751-800751ECIERIPWIA761PECVEDSKNL771SVAADKWSFG781TTLWEICYNG791EIPLKDKTLI
801-850801EKERFYESRC811RPVTPSCKEL821ADLMTRCMNY831DPNQRPFFRA841IMRDINKLEE
851-900851QNPDIVSEKK861PATEVDPTHF871EKRFLKRIRD881LGEGHFGKVE891LCRYDPEGDN
901-950901TGEQVAVKSL911KPESGGNHIA921DLKKEIEILR931NLYHENIVKY941KGICTEDGGN
951-1000951GIKLIMEFLP961SGSLKEYLPK971NKNKINLKQQ981LKYAVQICKG991MDYLGSRQYV
1001-10501001HRDLAARNVL1011VESEHQVKIG1021DFGLTKAIET1031DKEYYTVKDD1041RDSPVFWYAP
1051-11001051ECLMQSKFYI1061ASDVWSFGVT1071LHELLTYCDS1081DSSPMALFLK1091MIGPTHGQMT
1101-11501101VTRLVNTLKE1111GKRLPCPPNC1121PDEVYQLMRK1131CWEFQPSNRT1141SFQNLIEGFE
1151-11541151ALLK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 10 | - | - | - |
Deep-Palm: 0.02
|
|
| 16 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.40
|
|
| 61 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.87
|
|
| 68 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.64
|
|
| 74 | - | - | - |
Deep-Palm: 0.27
|
|
| 169 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.72
|
|
| 189 | - | - | - |
Deep-Palm: 0.10
|
|
| 257 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.71
|
|
| 424 | - | - | - |
Deep-Palm: 0.23
|
|
| 440 | - | - | - |
Deep-Palm: 0.20
|
|
| 445 | - | - | - |
Deep-Palm: 0.22
|
|
| 469 | - | - | - |
Deep-Palm: 0.16
|
|
| 481 | - | - | - |
Deep-Palm: 0.16
|
|
| 543 | SWISSPALM | SH2 domain | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.82
|
| 544 | SWISSPALM | SH2 domain | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.88
|
| 657 | - | - | - |
Deep-Palm: 0.04
|
|
| 716 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.92
|
|
| 731 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.95
|
|
| 752 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.84
|
|
| 763 | - | - | - |
Deep-Palm: 0.30
|
|
| 787 | - | - | - |
Deep-Palm: 0.31
|
|
| 810 | - | - | - |
Deep-Palm: 0.91
|
|
| 817 | - | - | - |
Deep-Palm: 0.07
|
|
| 827 | - | - | - |
Deep-Palm: 0.11
|
|
| 892 | - | - | - |
Deep-Palm: 0.65
|
|
| 944 | - | - | - |
Deep-Palm: 0.30
|
|
| 988 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.34
|
|
| 1052 | - | - | - |
Deep-Palm: 0.06
|
|
| 1078 | - | - | - |
Deep-Palm: 0.18
|
|
| 1116 | - | - | - |
Deep-Palm: 0.20
|
|
| 1120 | - | - | - |
Deep-Palm: 0.07
|
|
| 1131 | - | - | - |
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
Primary T cell
Specificity: 0.600
3/3 (100.0%)
1
HeLa cell
Specificity: 0.200
1/1 (100.0%)
1
HUVECs
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 189 | C → Y | 0.001014 | SNP | Missense Mutation | BRCA |
| 217 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 469 | C → Y | 0.001014 | SNP | Missense Mutation | BRCA |
| 532 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 542 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 729 | S → C | 0.005495 | SNP | Missense Mutation | LIHC |
| 787 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 958 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1093 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1097 | G → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1113 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1131 | C → Y | 0.001014 | SNP | Missense Mutation | BRCA |
| 1141 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 716* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |