Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P23458 | JAK1; JAK1A; JAK1B | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) … | Homo sapiens (Human) | 1154 aa |
Protein Details: P23458 (JAK1)
Protein Information
| Accession | P23458 |
|---|---|
| Protein Names | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) |
| Gene Symbol | JAK1; JAK1A; JAK1B |
| Organism | Homo sapiens (Human) |
| Length | 1154 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 26111759 29575903 32944167 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
4
PC3 cells
Specificity: 0.400
4/4 (100.0%)
4
T cells
Specificity: 0.400
4/4 (100.0%)
1
HeLa cells
Specificity: 0.100
1/1 (100.0%)
1
Endothelial cells
Specificity: 0.100
1/2 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MQYLNIKEDC11NAMAFCAKMR21SSKKTEVNLE31APEPGVEVIF41YLSDREPLRL
51-10051GSGEYTAEEL61CIRAAQACRI71SPLCHNLFAL81YDENTKLWYA91PNRTITVDDK
101-150101MSLRLHYRMR111FYFTNWHGTN121DNEQSVWRHS131PKKQKNGYEK141KKIPDATPLL
151-200151DASSLEYLFA161QGQYDLVKCL171APIRDPKTEQ181DGHDIENECL191GMAVLAISHY
201-250201AMMKKMQLPE211LPKDISYKRY221IPETLNKSIR231QRNLLTRMRI241NNVFKDFLKE
251-300251FNNKTICDSS261VSTHDLKVKY271LATLETLTKH281YGAEIFETSM291LLISSENEMN
301-350301WFHSNDGGNV311LYYEVMVTGN321LGIQWRHKPN331VVSVEKEKNK341LKRKKLENKH
351-400351KKDEEKNKIR361EEWNNFSYFP371EITHIVIKES381VVSINKQDNK391KMELKLSSHE
401-450401EALSFVSLVD411GYFRLTADAH421HYLCTDVAPP431LIVHNIQNGC441HGPICTEYAI
451-500451NKLRQEGSEE461GMYVLRWSCT471DFDNILMTVT481CFEKSEQVQG491AQKQFKNFQI
501-550501EVQKGRYSLH511GSDRSFPSLG521DLMSHLKKQI531LRTDNISFML541KRCCQPKPRE
551-600551ISNLLVATKK561AQEWQPVYPM571SQLSFDRILK581KDLVQGEHLG591RGTRTHIYSG
601-650601TLMDYKDDEG611TSEEKKIKVI621LKVLDPSHRD631ISLAFFEAAS641MMRQVSHKHI
651-700651VYLYGVCVRD661VENIMVEEFV671EGGPLDLFMH681RKSDVLTTPW691KFKVAKQLAS
701-750701ALSYLEDKDL711VHGNVCTKNL721LLAREGIDSE731CGPFIKLSDP741GIPITVLSRQ
751-800751ECIERIPWIA761PECVEDSKNL771SVAADKWSFG781TTLWEICYNG791EIPLKDKTLI
801-850801EKERFYESRC811RPVTPSCKEL821ADLMTRCMNY831DPNQRPFFRA841IMRDINKLEE
851-900851QNPDIVSEKK861PATEVDPTHF871EKRFLKRIRD881LGEGHFGKVE891LCRYDPEGDN
901-950901TGEQVAVKSL911KPESGGNHIA921DLKKEIEILR931NLYHENIVKY941KGICTEDGGN
951-1000951GIKLIMEFLP961SGSLKEYLPK971NKNKINLKQQ981LKYAVQICKG991MDYLGSRQYV
1001-10501001HRDLAARNVL1011VESEHQVKIG1021DFGLTKAIET1031DKEYYTVKDD1041RDSPVFWYAP
1051-11001051ECLMQSKFYI1061ASDVWSFGVT1071LHELLTYCDS1081DSSPMALFLK1091MIGPTHGQMT
1101-11501101VTRLVNTLKE1111GKRLPCPPNC1121PDEVYQLMRK1131CWEFQPSNRT1141SFQNLIEGFE
1151-11541151ALLK
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 16 | Prediction (Medium) | - | - |
| 61 | Prediction (Medium) | - | - |
| 68 | Prediction (Low) | - | - |
| 169 | Prediction (Low) | - | - |
| 257 | Prediction (Low) | - | - |
| 543 | SWISSPALM Prediction (Medium) | SH2 domain | - |
| 544 | SWISSPALM Prediction (High) | SH2 domain | - |
| 716 | Prediction (Low) | - | - |
| 731 | Prediction (Low) | - | - |
| 752 | Prediction (Low) | - | - |
| 988 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 189 | C → Y | 0.001014 | SNP | Missense Mutation | BRCA |
| 217 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 469 | C → Y | 0.001014 | SNP | Missense Mutation | BRCA |
| 532 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 542 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 729 | S → C | 0.005495 | SNP | Missense Mutation | LIHC |
| 787 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 958 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1093 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1097 | G → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1113 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1131 | C → Y | 0.001014 | SNP | Missense Mutation | BRCA |
| 1141 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 716* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |