Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P23528 | CFL1; CFL | Cofilin-1 (18 kDa phosphoprotein) (p18) … | Homo sapiens (Human) | 166 aa |
Protein Details: P23528 (CFL1)
Protein Information
| Accession | P23528 |
|---|---|
| Protein Names | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) |
| Gene Symbol | CFL1; CFL |
| Organism | Homo sapiens (Human) |
| Length | 166 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 22496122 29575903 29733200 31251020 32944167 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.556
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
35
LNCaP cells
Specificity: 0.556
35/46 (76.1%)
10
HAP1 cells
Specificity: 0.159
10/10 (100.0%)
6
Jurkat T cells
Specificity: 0.095
6/25 (24.0%)
4
293T cells
Specificity: 0.063
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.063
4/4 (100.0%)
3
PC3 cells
Specificity: 0.048
3/4 (75.0%)
1
Endothelial cells
Specificity: 0.016
1/2 (50.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MASGVAVSDG11VIKVFNDMKV21RKSSTPEEVK31KRKKAVLFCL41SEDKKNIILE
51-10051EGKEILVGDV61GQTVDDPYAT71FVKMLPDKDC81RYALYDATYE91TKESKKEDLV
101-150101FIFWAPESAP111LKSKMIYASS121KDAIKKKLTG131IKHELQANCY141EEVKDRCTLA
151-166151EKLGGSAVIS161LEGKPL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 39 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | - | 29575903 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 32 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 80 | C → C | 0.002427 | SNP | Silent | BLCA |