Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P23528 | CFL1 | Cofilin-1 (18 kDa phosphoprotein) (p18) … | Homo sapiens (Human) | 166 aa |
Protein Details: P23528 (CFL1)
Protein Information
| Accession | P23528 |
|---|---|
| Protein Names | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) |
| Gene Symbol | CFL1 |
| Organism | Homo sapiens (Human) |
| Length | 166 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 22496122 29733200 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASGVAVSDG11VIKVFNDMKV21RKSSTPEEVK31KRKKAVLFCL41SEDKKNIILE
51-10051EGKEILVGDV61GQTVDDPYAT71FVKMLPDKDC81RYALYDATYE91TKESKKEDLV
101-150101FIFWAPESAP111LKSKMIYASS121KDAIKKKLTG131IKHELQANCY141EEVKDRCTLA
151-166151EKLGGSAVIS161LEGKPL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 39 | SWISSPALM DBPTM CYSMODDB | Actin depolymerizing proteins ADF-H/Gelsolin-like domain superfamily |
SW480 cell line
(26865113)
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.98
|
| 80 | - | - | - |
Deep-Palm: 0.74
|
|
| 139 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.93
|
|
| 147 | - | - | - |
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
4
cerebral cortex
Specificity: 0.250
4/4 (100.0%)
3
LNCaP
Specificity: 0.188
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.125
2/2 (100.0%)
1
Jurkat T cell
Specificity: 0.062
1/1 (100.0%)
1
EC cell
Specificity: 0.062
1/1 (100.0%)
1
293T cell
Specificity: 0.062
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.250
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 32 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 80 | C → C | 0.002427 | SNP | Silent | BLCA |