Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P23786 | CPT2 | Carnitine O-palmitoyltransferase 2, mitochondrial (EC … | Homo sapiens (Human) | 658 aa |
Protein Details: P23786 (CPT2)
Protein Information
| Accession | P23786 |
|---|---|
| Protein Names | Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II) |
| Gene Symbol | CPT2 |
| Organism | Homo sapiens (Human) |
| Length | 658 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 33636221 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVPRLLLRAW11PRGPAVGPGA21PSRPLSAGSG31PGQYLQRSIV41PTMHYQDSLP
51-10051RLPIPKLEDT61IRRYLSAQKP71LLNDGQFRKT81EQFCKSFENG91IGKELHEQLV
101-150101ALDKQNKHTS111YISGPWFDMY121LSARDSVVLN131FNPFMAFNPD141PKSEYNDQLT
151-200151RATNMTVSAI161RFLKTLRAGL171LEPEVFHLNP181AKSDTITFKR191LIRFVPSSLS
201-250201WYGAYLVNAY211PLDMSQYFRL221FNSTRLPKPS231RDELFTDDKA241RHLLVLRKGN
251-300251FYIFDVLDQD261GNIVSPSEIQ271AHLKYILSDS281SPAPEFPLAY291LTSENRDIWA
301-350301ELRQKLMSSG311NEESLRKVDS321AVFCLCLDDF331PIKDLVHLSH341NMLHGDGTNR
351-400351WFDKSFNLII361AKDGSTAVHF371EHSWGDGVAV381LRFFNEVFKD391STQTPAVTPQ
401-450401SQPATTDSTV411TVQKLNFELT421DALKTGITAA431KEKFDATMKT441LTIDCVQFQR
451-500451GGKEFLKKQK461LSPDAVAQLA471FQMAFLRQYG481QTVATYESCS491TAAFKHGRTE
501-550501TIRPASVYTK511RCSEAFVREP521SRHSAGELQQ531MMVECSKYHG541QLTKEAAMGQ
551-600551GFDRHLFALR561HLAAAKGIIL571PELYLDPAYG581QINHNVLSTS591TLSSPAVNLG
601-650601GFAPVVSDGF611GVGYAVHDNW621IGCNVSSYPG631RNAREFLQCV641EKALEDMFDA
651-658651LEGKSIKS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 84 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.86
|
|
| 324 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.69
|
|
| 326 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.70
|
|
| 445 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.95
|
|
| 489 | - | - | - |
Deep-Palm: 0.81
|
|
| 512 | - | - | - |
Deep-Palm: 0.88
|
|
| 535 | - | - | - |
Deep-Palm: 0.76
|
|
| 623 | - | - | - |
Deep-Palm: 0.73
|
|
| 639 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.92
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
LNCaP
Specificity: 0.600
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.200
1/1 (100.0%)
1
heart
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 215 | S → C | 0.002506 | SNP | Missense Mutation | COAD |
| 218 | F → C | 0.002545 | SNP | Missense Mutation | GBM |
| 445 | C → C | 0.001887 | SNP | Silent | UCEC |
| 497 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 512 | C → S | 0.001887 | SNP | Missense Mutation | UCEC |
| 620 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |