Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P24530 EDNRB Endothelin receptor type B (ET-B) … Homo sapiens (Human) 442 aa

Protein Details: P24530 (EDNRB)

Protein Information
AccessionP24530
Protein NamesEndothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type)
Gene SymbolEDNRB
OrganismHomo sapiens (Human)
Length442 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MQPPPSLCGR11ALVALVLACG21LSRIWGEERG31FPPDRATPLL41QTAEIMTPPT
51-10051KTLWPKGSNA61SLARSLAPAE71VPKGDRTAGS81PPRTISPPPC91QGPIEIKETF
101-150101KYINTVVSCL111VFVLGIIGNS121TLLRIIYKNK131CMRNGPNILI141ASLALGDLLH
151-200151IVIDIPINVY161KLLAEDWPFG171AEMCKLVPFI181QKASVGITVL191SLCALSIDRY
201-250201RAVASWSRIK211GIGVPKWTAV221EIVLIWVVSV231VLAVPEAIGF241DIITMDYKGS
251-300251YLRICLLHPV261QKTAFMQFYK271TAKDWWLFSF281YFCLPLAITA291FFYTLMTCEM
301-350301LRKKSGMQIA311LNDHLKQRRE321VAKTVFCLVL331VFALCWLPLH341LSRILKLTLY
351-400351NQNDPNRCEL361LSFLLVLDYI371GINMASLNSC381INPIALYLVS391KRFKNCFKSC
401-442401LCCWCQSFEE411KQSLEEKQSC421LKFKANDHGY431DNFRSSNKYS441SS
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
8 Endothelin receptor B - -
GPS-Palm: 0.93
Deep-Palm: 0.23
19 Endothelin receptor B - -
GPS-Palm: 0.96
Deep-Palm: 0.98
90 - -
cerebral cortex (36430497)
GPS-Palm: 0.73
Deep-Palm: 0.55
109 - - -
GPS-Palm: 0.76
Deep-Palm: 0.88
131 - - -
GPS-Palm: 0.78
Deep-Palm: 0.83
174 - - -
Deep-Palm: 0.93
193 - - -
GPS-Palm: 0.91
Deep-Palm: 0.89
255 - - -
GPS-Palm: 0.77
Deep-Palm: 0.27
283 - - -
Deep-Palm: 0.03
298 - - -
GPS-Palm: 0.86
Deep-Palm: 0.68
327 - - -
GPS-Palm: 0.71
Deep-Palm: 0.82
335 - - -
GPS-Palm: 0.79
Deep-Palm: 0.81
358 - - -
Deep-Palm: 0.67
380 - - -
GPS-Palm: 0.66
Deep-Palm: 0.85
396 - - -
GPS-Palm: 0.94
Deep-Palm: 0.22
400 DBPTM SWISSPALM - - -
GPS-Palm: 0.96
Deep-Palm: 0.52
402 DBPTM SWISSPALM - - -
GPS-Palm: 0.96
Deep-Palm: 0.46
403 DBPTM SWISSPALM - - -
GPS-Palm: 0.96
Deep-Palm: 0.51
405 DBPTM SWISSPALM - - -
GPS-Palm: 0.88
Deep-Palm: 0.18
420 - - -
GPS-Palm: 0.74
Deep-Palm: 0.60
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
90 C → Y 0.002288 SNP Missense Mutation STAD
109 C → Mfs*46 0.002545 INS Frame Shift Ins GBM
109 C → C 0.002033 SNP Silent LUSC
127 Y → C 0.001887 SNP Missense Mutation UCEC
131 C → W 0.001764 SNP Missense Mutation LUAD
191 S → C 0.002288 SNP Missense Mutation STAD
193 C → C 0.002141 SNP Silent SKCM
281 Y → C 0.002747 SNP Missense Mutation LIHC
298 C → F 0.001764 SNP Missense Mutation LUAD
298 C → Vfs*4 0.002033 DEL Frame Shift Del LUSC
402 C → C 0.001887 SNP Silent UCEC
436 S → C 0.001764 SNP Missense Mutation LUAD
? ? → ? 0.001887 SNP Silent UCEC
335* C → ? 0.001887 SNP Nonsense Mutation UCEC