Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P24588 | AKAP5 | A-kinase anchor protein 5 (AKAP-5) … | Homo sapiens (Human) | 427 aa |
Protein Details: P24588 (AKAP5)
Protein Information
| Accession | P24588 |
|---|---|
| Protein Names | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) |
| Gene Symbol | AKAP5 |
| Organism | Homo sapiens (Human) |
| Length | 427 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501METTISEIHV11ENKDEKRSAE21GSPGAERQKE31KASMLCFKRR41KKAAKALKPK
51-10051AGSEAADVAR61KCPQEAGASD71QPEPTRGAWA81SLKRLVTRRK91RSESSKQQKP
101-150101LEGEMQPAIN111AEDADLSKKK121AKSRLKIPCI131KFPRGPKRSN141HSKIIEDSDC
151-200151SIKVQEEAEI161LDIQTQTPLN171DQATKAKSTQ181DLSEGISRKD191GDEVCESNVS
201-250201NSTTSGEKVI211SVELGLDNGH221SAIQTGTLIL231EEIETIKEKQ241DVQPQQASPL
251-300251ETSETDHQQP261VLSDVPPLPA271IPDQQIVEEA281SNSTLESAPN291GKDYESTEIV
301-350301AEETKPKDTE311LSQESDFKEN321GITEEKSKSE331ESKRMEPIAI341IITDTEISEF
351-400351DVTKSKNVPK361QFLISAENEQ371VGVFANDNGF381EDRTSEQYET391LLIETASSLV
401-427401KNAIQLSIEQ411LVNEMASDDN421KINNLLQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 36 | DBPTM SWISSPALM | A-kinase anchor protein 5 | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
| 62 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.98
|
|
| 129 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.97
|
| 150 | - | - | - |
Deep-Palm: 0.85
|
|
| 195 | - | - | - |
Deep-Palm: 0.69
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
LNCaP
Specificity: 0.267
4/4 (100.0%)
3
PC3
Specificity: 0.200
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.200
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.067
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 21 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 62 | C → R | 0.002545 | SNP | Missense Mutation | GBM |