Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P25101 | EDNRA | Endothelin-1 receptor (Endothelin receptor type … | Homo sapiens (Human) | 427 aa |
Protein Details: P25101 (EDNRA)
Protein Information
| Accession | P25101 |
|---|---|
| Protein Names | Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) |
| Gene Symbol | EDNRA |
| Organism | Homo sapiens (Human) |
| Length | 427 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501METLCLRASF11WLALVGCVIS21DNPERYSTNL31SNHVDDFTTF41RGTELSFLVT
51-10051THQPTNLVLP61SNGSMHNYCP71QQTKITSAFK81YINTVISCTI91FIVGMVGNAT
101-150101LLRIIYQNKC111MRNGPNALIA121SLALGDLIYV131VIDLPINVFK141LLAGRWPFDH
151-200151NDFGVFLCKL161FPFLQKSSVG171ITVLNLCALS181VDRYRAVASW191SRVQGIGIPL
201-250201VTAIEIVSIW211ILSFILAIPE221AIGFVMVPFE231YRGEQHKTCM241LNATSKFMEF
251-300251YQDVKDWWLF261GFYFCMPLVC271TAIFYTLMTC281EMLNRRNGSL291RIALSEHLKQ
301-350301RREVAKTVFC311LVVIFALCWF321PLHLSRILKK331TVYNEMDKNR341CELLSFLLLM
351-400351DYIGINLATM361NSCINPIALY371FVSKKFKNCF381QSCLCCCCYQ391SKSLMTSVPM
401-427401NGTSIQWKNH411DQNNHNTDRS421SHKDSMN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 5 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.04
|
|
| 17 | Endothelin receptor A | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.88
|
|
| 69 | - | - | - |
Deep-Palm: 0.05
|
|
| 88 | - | - | - |
Deep-Palm: 0.33
|
|
| 110 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.89
|
|
| 158 | - | - | - |
Deep-Palm: 0.72
|
|
| 177 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.88
|
|
| 239 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.05
|
|
| 265 | - | - | - |
Deep-Palm: 0.02
|
|
| 270 | - | - | - |
Deep-Palm: 0.03
|
|
| 280 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.65
|
|
| 310 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.50
|
|
| 318 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.46
|
|
| 341 | - | - | - |
Deep-Palm: 0.37
|
|
| 363 | - | - | - |
Deep-Palm: 0.20
|
|
| 379 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.13
|
|
| 383 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.21
|
| 385 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.15
|
| 386 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.14
|
| 387 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.16
|
| 388 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.15
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 40 | F → C | 0.002545 | SNP | Missense Mutation | GBM |
| 41 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 145 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 164 | L → Cfs*38 | 0.002288 | DEL | Frame Shift Del | STAD |
| 192 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 352 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 310* | C → ? | 0.001887 | SNP | Nonsense Mutation | UCEC |