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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P25116 F2R; CF2R; PAR1; TR Proteinase-activated receptor 1 (PAR-1) (Coagulation … Homo sapiens (Human) 425 aa

Protein Details: P25116 (F2R)

Protein Information
Accession P25116
Protein Names Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Gene Symbol F2R; CF2R; PAR1; TR
Organism Homo sapiens (Human)
Length 425 aa
Isoforms No isoforms
Related PMIDs 31251020 32944167
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.846
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
11
LNCaP cells
Specificity: 0.846
11/46 (23.9%)
2
PC3 cells
Specificity: 0.154
2/4 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGPRRLLLVA11ACFSLCGPLL21SARTRARRPE31SKATNATLDP41RSFLLRNPND
51-10051KYEPFWEDEE61KNESGLTEYR71LVSINKSSPL81QKQLPAFISE91DASGYLTSSW
101-150101LTLFVPSVYT111GVFVVSLPLN121IMAIVVFILK131MKVKKPAVVY141MLHLATADVL
151-200151FVSVLPFKIS161YYFSGSDWQF171GSELCRFVTA181AFYCNMYASI191LLMTVISIDR
201-250201FLAVVYPMQS211LSWRTLGRAS221FTCLAIWALA231IAGVVPLLLK241EQTIQVPGLN
251-300251ITTCHDVLNE261TLLEGYYAYY271FSAFSAVFFF281VPLIISTVCY291VSIIRCLSSS
301-350301AVANRSKKSR311ALFLSAAVFC321IFIICFGPTN331VLLIAHYSFL341SHTSTTEAAY
351-400351FAYLLCVCVS361SISCCIDPLI371YYYASSECQR381YVYSILCCKE391SSDPSSYNSS
401-425401GQLMASKMDT411CSSNLNNSIY421KKLLT
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
12 Prediction (High) - -
16 Prediction (High) - -
223 Prediction (Medium) - -
289 Prediction (Medium) - -
296 Prediction (Low) - -
320 Prediction (Low) - -
387 DBPTM SWISSPALM - -
388 DBPTM SWISSPALM - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
104 F → Cfs*54 0.002506 DEL Frame Shift Del COAD
165 G → C 0.002033 SNP Missense Mutation LUSC
175 C → R 0.001887 SNP Missense Mutation UCEC
254 C → Y 0.001764 SNP Missense Mutation LUAD
265 G → C 0.001764 SNP Missense Mutation LUAD
296 C → F 0.004219 SNP Missense Mutation SARC
320 C → C 0.001887 SNP Silent UCEC
325 C → S 0.002506 SNP Missense Mutation COAD
356 C → R 0.002033 SNP Missense Mutation LUSC
378 C → C 0.001887 SNP Silent UCEC
388* C → ? 0.001764 SNP Nonsense Mutation LUAD
411* C → ? 0.002545 SNP Nonsense Mutation GBM