Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P25116 | F2R | Proteinase-activated receptor 1 (PAR-1) (Coagulation … | Homo sapiens (Human) | 425 aa |
Protein Details: P25116 (F2R)
Protein Information
| Accession | P25116 |
|---|---|
| Protein Names | Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor) |
| Gene Symbol | F2R |
| Organism | Homo sapiens (Human) |
| Length | 425 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGPRRLLLVA11ACFSLCGPLL21SARTRARRPE31SKATNATLDP41RSFLLRNPND
51-10051KYEPFWEDEE61KNESGLTEYR71LVSINKSSPL81QKQLPAFISE91DASGYLTSSW
101-150101LTLFVPSVYT111GVFVVSLPLN121IMAIVVFILK131MKVKKPAVVY141MLHLATADVL
151-200151FVSVLPFKIS161YYFSGSDWQF171GSELCRFVTA181AFYCNMYASI191LLMTVISIDR
201-250201FLAVVYPMQS211LSWRTLGRAS221FTCLAIWALA231IAGVVPLLLK241EQTIQVPGLN
251-300251ITTCHDVLNE261TLLEGYYAYY271FSAFSAVFFF281VPLIISTVCY291VSIIRCLSSS
301-350301AVANRSKKSR311ALFLSAAVFC321IFIICFGPTN331VLLIAHYSFL341SHTSTTEAAY
351-400351FAYLLCVCVS361SISCCIDPLI371YYYASSECQR381YVYSILCCKE391SSDPSSYNSS
401-425401GQLMASKMDT411CSSNLNNSIY421KKLLT
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 12 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.96
|
|
| 16 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.98
|
|
| 175 | - | - | - |
Deep-Palm: 0.02
|
|
| 184 | - | - | - |
Deep-Palm: 0.04
|
|
| 223 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.87
|
|
| 254 | - | - | - |
Deep-Palm: 0.48
|
|
| 289 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.57
|
|
| 296 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.61
|
|
| 320 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.73
|
|
| 325 | - | - | - |
Deep-Palm: 0.26
|
|
| 356 | - | - | - |
Deep-Palm: 0.06
|
|
| 358 | - | - | - |
Deep-Palm: 0.05
|
|
| 364 | - | - | - |
Deep-Palm: 0.04
|
|
| 365 | - | - | - |
Deep-Palm: 0.04
|
|
| 378 | - | - | - |
Deep-Palm: 0.05
|
|
| 387 | DBPTM SWISSPALM | - | - | - |
Deep-Palm: 0.32
|
| 388 | DBPTM SWISSPALM | - | - | - |
Deep-Palm: 0.55
|
| 411 | - | - | - |
Deep-Palm: 0.51
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
PC3
Specificity: 0.667
2/2 (100.0%)
1
LNCaP
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 104 | F → Cfs*54 | 0.002506 | DEL | Frame Shift Del | COAD |
| 165 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 175 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 254 | C → Y | 0.001764 | SNP | Missense Mutation | LUAD |
| 265 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 296 | C → F | 0.004219 | SNP | Missense Mutation | SARC |
| 320 | C → C | 0.001887 | SNP | Silent | UCEC |
| 325 | C → S | 0.002506 | SNP | Missense Mutation | COAD |
| 356 | C → R | 0.002033 | SNP | Missense Mutation | LUSC |
| 378 | C → C | 0.001887 | SNP | Silent | UCEC |
| 388* | C → ? | 0.001764 | SNP | Nonsense Mutation | LUAD |
| 411* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |