Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P25398 | RPS12 | Small ribosomal subunit protein eS12 … | Homo sapiens (Human) | 132 aa |
Protein Details: P25398 (RPS12)
Protein Information
| Accession | P25398 |
|---|---|
| Protein Names | Small ribosomal subunit protein eS12 (40S ribosomal protein S12) |
| Gene Symbol | RPS12 |
| Organism | Homo sapiens (Human) |
| Length | 132 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAEEGIAAGG11VMDVNTALQE21VLKTALIHDG31LARGIREAAK41ALDKRQAHLC
51-10051VLASNCDEPM61YVKLVEALCA71EHQINLIKVD81DNKKLGEWVG91LCKIDREGKP
101-132101RKVVGCSCVV111VKDYGKESQA121KDVIEEYFKC131KK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 50 | Ribosomal protein eL30-like superfamily Ribosomal protein eL8/eL30/eS12/Gadd45 40S RIBOSOMAL PROTEIN S12 | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.95
|
|
| 56 | - | - | - |
Deep-Palm: 0.88
|
|
| 69 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.21
|
|
| 92 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.95
|
|
| 106 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.90
|
| 108 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.92
|
| 130 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
3
PC3
Specificity: 0.429
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.286
2/2 (100.0%)
1
LNCaP
Specificity: 0.143
1/1 (100.0%)
1
293T cell
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 61 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| ? | ? → ? | 0.002294 | SNP | Nonstop Mutation | OV |