Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P27144 | AK4 | Adenylate kinase 4, mitochondrial (EC … | Homo sapiens (Human) | 223 aa |
Protein Details: P27144 (AK4)
Protein Information
| Accession | P27144 |
|---|---|
| Protein Names | Adenylate kinase 4, mitochondrial (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4) |
| Gene Symbol | AK4 |
| Organism | Homo sapiens (Human) |
| Length | 223 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 33636221 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASKLLRAVI11LGPPGSGKGT21VCQRIAQNFG31LQHLSSGHFL41RENIKASTEV
51-10051GEMAKQYIEK61SLLVPDHVIT71RLMMSELENR81RGQHWLLDGF91PRTLGQAEAL
101-150101DKICEVDLVI111SLNIPFETLK121DRLSRRWIHP131PSGRVYNLDF141NPPHVHGIDD
151-200151VTGEPLVQQE161DDKPEAVAAR171LRQYKDVAKP181VIELYKSRGV191LHQFSGTETN
201-223201KIWPYVYTLF211SNKITPIQSK221EAY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 22 | Adenylate kinase/UMP-CMP kinase Adenylate kinase P-loop containing nucleoside triphosphate hydrolase | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.95
|
|
| 104 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
LNCaP
Specificity: 0.667
2/2 (100.0%)
1
heart
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 104 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |