Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P27348 | YWHAQ | 14-3-3 protein theta (14-3-3 protein … | Homo sapiens (Human) | 245 aa |
Protein Details: P27348 (YWHAQ)
Protein Information
| Accession | P27348 |
|---|---|
| Protein Names | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) |
| Gene Symbol | YWHAQ |
| Organism | Homo sapiens (Human) |
| Length | 245 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29733200 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEKTELIQKA11KLAEQAERYD21DMATCMKAVT31EQGAELSNEE41RNLLSVAYKN
51-10051VVGGRRSAWR61VISSIEQKTD71TSDKKLQLIK81DYREKVESEL91RSICTTVLEL
101-150101LDKYLIANAT111NPESKVFYLK121MKGDYFRYLA131EVACGDDRKQ141TIDNSQGAYQ
151-200151EAFDISKKEM161QPTHPIRLGL171ALNFSVFYYE181ILNNPELACT191LAKTAFDEAI
201-245201AELDTLNEDS211YKDSTLIMQL221LRDNLTLWTS231DSAGEECDAA241EGAEN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 25 | 14-3-3 domain superfamily 14-3-3 domain 14-3-3 protein | - |
Unknown
(32651440)
|
GPS-Palm: 0.75
Deep-Palm: 0.89
|
|
| 94 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 134 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.85
Deep-Palm: 0.83
|
|
| 189 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.86
|
|
| 237 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.01
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
2
HAP1 cell
Specificity: 0.154
2/2 (100.0%)
1
LNCaP
Specificity: 0.077
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.077
1/1 (100.0%)
1
293T cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 19 | Y → C | 0.012195 | SNP | Missense Mutation | MESO |
| 125 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 139 | K → _Q140insLACGDDRK | 0.002427 | INS | In Frame Ins | BLCA |
| 139 | K → _Q140insLACGDDRK | 0.002033 | INS | In Frame Ins | LUSC |
| 167 | R → C | 0.002288 | SNP | Missense Mutation | STAD |