Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P27695 | APEX1 | DNA repair nuclease/redox regulator APEX1 … | Homo sapiens (Human) | 318 aa |
Protein Details: P27695 (APEX1)
Protein Information
| Accession | P27695 |
|---|---|
| Protein Names | DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] |
| Gene Symbol | APEX1 |
| Organism | Homo sapiens (Human) |
| Length | 318 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPKRGKKGAV11AEDGDELRTE21PEAKKSKTAA31KKNDKEAAGE41GPALYEDPPD
51-10051QKTSPSGKPA61TLKICSWNVD71GLRAWIKKKG81LDWVKEEAPD91ILCLQETKCS
101-150101ENKLPAELQE111LPGLSHQYWS121APSDKEGYSG131VGLLSRQCPL141KVSYGIGDEE
151-200151HDQEGRVIVA161EFDSFVLVTA171YVPNAGRGLV181RLEYRQRWDE191AFRKFLKGLA
201-250201SRKPLVLCGD211LNVAHEEIDL221RNPKGNKKNA231GFTPQERQGF241GELLQAVPLA
251-300251DSFRHLYPNT261PYAYTFWTYM271MNARSKNVGW281RLDYFLLSHS291LLPALCDSKI
301-318301RSKALGSDHC311PITLYLAL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 65 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.93
|
|
| 93 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.95
|
|
| 99 | - | - | - |
Deep-Palm: 0.97
|
|
| 138 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.94
|
|
| 208 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.98
|
|
| 296 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.90
Deep-Palm: 0.95
|
|
| 310 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.09
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.429
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.286
2/2 (100.0%)
1
293T cell
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Jurkat T cells (Mass)
Specificity: 0.143
1/10 (10.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 193 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 206 | V → Cfs*11 | 0.001764 | INS | Frame Shift Ins | LUAD |
| 281 | R → C | 0.003460 | SNP | Missense Mutation | CESC |