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UniProt ID Gene Symbol Protein Name Organism Length Action
P27695 APEX1; APE; APE1; APEX; APX; HAP1; REF1 DNA repair nuclease/redox regulator APEX1 … Homo sapiens (Human) 318 aa

Protein Details: P27695 (APEX1)

Protein Information
Accession P27695
Protein Names DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial]
Gene Symbol APEX1; APE; APE1; APEX; APX; HAP1; REF1
Organism Homo sapiens (Human)
Length 318 aa
Isoforms No isoforms
Related PMIDs 21076176 29575903 29733200 31251020 32944167
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.642
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
34
LNCaP cells
Specificity: 0.642
34/46 (73.9%)
10
HAP1 cells
Specificity: 0.189
10/10 (100.0%)
4
293T cells
Specificity: 0.075
4/10 (40.0%)
3
PC3 cells
Specificity: 0.057
3/4 (75.0%)
2
Jurkat T cells
Specificity: 0.038
2/25 (8.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MPKRGKKGAV11AEDGDELRTE21PEAKKSKTAA31KKNDKEAAGE41GPALYEDPPD
51-10051QKTSPSGKPA61TLKICSWNVD71GLRAWIKKKG81LDWVKEEAPD91ILCLQETKCS
101-150101ENKLPAELQE111LPGLSHQYWS121APSDKEGYSG131VGLLSRQCPL141KVSYGIGDEE
151-200151HDQEGRVIVA161EFDSFVLVTA171YVPNAGRGLV181RLEYRQRWDE191AFRKFLKGLA
201-250201SRKPLVLCGD211LNVAHEEIDL221RNPKGNKKNA231GFTPQERQGF241GELLQAVPLA
251-300251DSFRHLYPNT261PYAYTFWTYM271MNARSKNVGW281RLDYFLLSHS291LLPALCDSKI
301-318301RSKALGSDHC311PITLYLAL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
65 Prediction (Medium) - -
138 Prediction (Medium) - -
208 Prediction (Medium) - -
296 Prediction (High) - -
310 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Low) - 29575903
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
193 R → C 0.007299 SNP Missense Mutation READ
206 V → Cfs*11 0.001764 INS Frame Shift Ins LUAD
281 R → C 0.003460 SNP Missense Mutation CESC
311 C → Y 0.002506 SNP Missense Mutation COAD
336 S → C 0.002427 SNP Missense Mutation BLCA
400 M → Cfs*48 0.002427 DEL Frame Shift Del BLCA
458 R → C 0.007299 SNP Missense Mutation READ
525 R → C 0.001887 SNP Missense Mutation UCEC
651 G → C 0.002033 SNP Missense Mutation LUSC