Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P27708 CAD Multifunctional protein CAD (Carbamoyl phosphate … Homo sapiens (Human) 2225 aa

Protein Details: P27708 (CAD)

Protein Information
Accession P27708
Protein Names Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene Symbol CAD
Organism Homo sapiens (Human)
Length 2225 aa
Isoforms No isoforms
Related PMIDs 29575903 29733200 31251020 32944167 37611173
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.708
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
34
LNCaP cells
Specificity: 0.708
34/46 (73.9%)
10
HAP1 cells
Specificity: 0.208
10/10 (100.0%)
3
PC3 cells
Specificity: 0.062
3/4 (75.0%)
1
HeLa cells
Specificity: 0.021
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAALVLEDGS11VLRGQPFGAA21VSTAGEVVFQ31TGMVGYPEAL41TDPSYKAQIL
51-10051VLTYPLIGNY61GIPPDEMDEF71GLCKWFESSG81IHVAALVVGE91CCPTPSHWSA
101-150101TRTLHEWLQQ111HGIPGLQGVD121TRELTKKLRE131QGSLLGKLVQ141NGTEPSSLPF
151-200151LDPNARPLVP161EVSIKTPRVF171NTGGAPRILA181LDCGLKYNQI191RCLCQRGAEV
201-250201TVVPWDHALD211SQEYEGLFLS221NGPGDPASYP231SVVSTLSRVL241SEPNPRPVFG
251-300251ICLGHQLLAL261AIGAKTYKMR271YGNRGHNQPC281LLVGSGRCFL291TSQNHGFAVE
301-350301TDSLPADWAP311LFTNANDGSN321EGIVHNSLPF331FSVQFHPEHQ341AGPSDMELLF
351-400351DIFLETVKEA361TAGNPGGQTV371RERLTERLCP381PGIPTPGSGL391PPPRKVLILG
401-450401SGGLSIGQAG411EFDYSGSQAI421KALKEENIQT431LLINPNIATV441QTSQGLADKV
451-500451YFLPITPHYV461TQVIRNERPD471GVLLTFGGQT481ALNCGVELTK491AGVLARYGVR
501-550501VLGTPVETIE511LTEDRRAFAA521RMAEIGEHVA531PSEAANSLEQ541AQAAAERLGY
551-600551PVLVRAAFAL561GGLGSGFASN571REELSALVAP581AFAHTSQVLV591DKSLKGWKEI
601-650601EYEVVRDAYG611NCVTVCNMEN621LDPLGIHTGE631SIVVAPSQTL641NDREYQLLRQ
651-700651TAIKVTQHLG661IVGECNVQYA671LNPESEQYYI681IEVNARLSRS691SALASKATGY
701-750701PLAYVAAKLA711LGIPLPELRN721SVTGGTAAFE731PSVDYCVVKI741PRWDLSKFLR
751-800751VSTKIGSCMK761SVGEVMGIGR771SFEEAFQKAL781RMVDENCVGF791DHTVKPVSDM
801-850801ELETPTDKRI811FVVAAALWAG821YSVDRLYELT831RIDRWFLHRM841KRIIAHAQLL
851-900851EQHRGQPLPP861DLLQQAKCLG871FSDKQIALAV881LSTELAVRKL891RQELGICPAV
901-950901KQIDTVAAEW911PAQTNYLYLT921YWGTTHDLTF931RTPHVLVLGS941GVYRIGSSVE
951-1000951FDWCAVGCIQ961QLRKMGYKTI971MVNYNPETVS981TDYDMCDRLY991FDEISFEVVM
1001-10501001DIYELENPEG1011VILSMGGQLP1021NNMAMALHRQ1031QCRVLGTSPE1041AIDSAENRFK
1051-11001051FSRLLDTIGI1061SQPQWRELSD1071LESARQFCQT1081VGYPCVVRPS1091YVLSGAAMNV
1101-11501101AYTDGDLERF1111LSSAAAVSKE1121HPVVISKFIQ1131EAKEIDVDAV1141ASDGVVAAIA
1151-12001151ISEHVENAGV1161HSGDATLVTP1171PQDITAKTLE1181RIKAIVHAVG1191QELQVTGPFN
1201-12501201LQLIAKDDQL1211KVIECNVRVS1221RSFPFVSKTL1231GVDLVALATR1241VIMGEEVEPV
1251-13001251GLMTGSGVVG1261VKVPQFSFSR1271LAGADVVLGV1281EMTSTGEVAG1291FGESRCEAYL
1301-13501301KAMLSTGFKI1311PKKNILLTIG1321SYKNKSELLP1331TVRLLESLGY1341SLYASLGTAD
1351-14001351FYTEHGVKVT1361AVDWHFEEAV1371DGECPPQRSI1381LEQLAEKNFE1391LVINLSMRGA
1401-14501401GGRRLSSFVT1411KGYRTRRLAA1421DFSVPLIIDI1431KCTKLFVEAL1441GQIGPAPPLK
1451-15001451VHVDCMTSQK1461LVRLPGLIDV1471HVHLREPGGT1481HKEDFASGTA1491AALAGGITMV
1501-15501501CAMPNTRPPI1511IDAPALALAQ1521KLAEAGARCD1531FALFLGASSE1541NAGTLGTVAG
1551-16001551SAAGLKLYLN1561ETFSELRLDS1571VVQWMEHFET1581WPSHLPIVAH1591AEQQTVAAVL
1601-16501601MVAQLTQRSV1611HICHVARKEE1621ILLIKAAKAR1631GLPVTCEVAP1641HHLFLSHDDL
1651-17001651ERLGPGKGEV1661RPELGSRQDV1671EALWENMAVI1681DCFASDHAPH1691TLEEKCGSRP
1701-17501701PPGFPGLETM1711LPLLLTAVSE1721GRLSLDDLLQ1731RLHHNPRRIF1741HLPPQEDTYV
1751-18001751EVDLEHEWTI1761PSHMPFSKAH1771WTPFEGQKVK1781GTVRRVVLRG1791EVAYIDGQVL
1801-18501801VPPGYGQDVR1811KWPQGAVPQL1821PPSAPATSEM1831TTTPERPRRG1841IPGLPDGRFH
1851-19001851LPPRIHRASD1861PGLPAEEPKE1871KSSRKVAEPE1881LMGTPDGTCY1891PPPPVPRQAS
1901-19501901PQNLGTPGLL1911HPQTSPLLHS1921LVGQHILSVQ1931QFTKDQMSHL1941FNVAHTLRMM
1951-20001951VQKERSLDIL1961KGKVMASMFY1971EVSTRTSSSF1981AAAMARLGGA1991VLSFSEATSS
2001-20502001VQKGESLADS2011VQTMSCYADV2021VVLRHPQPGA2031VELAAKHCRR2041PVINAGDGVG
2051-21002051EHPTQALLDI2061FTIREELGTV2071NGMTITMVGD2081LKHGRTVHSL2091ACLLTQYRVS
2101-21502101LRYVAPPSLR2111MPPTVRAFVA2121SRGTKQEEFE2131SIEEALPDTD2141VLYMTRIQKE
2151-22002151RFGSTQEYEA2161CFGQFILTPH2171IMTRAKKKMV2181VMHPMPRVNE2191ISVEVDSDPR
2201-22252201AAYFRQAENG2211MYIRMALLAT2221VLGRF
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
183 Prediction (High) - -
194 Prediction (Low) - -
379 Prediction (Medium) - -
484 Prediction (Low) - -
758 Prediction (Medium) - -
787 Prediction (Medium) - -
868 Prediction (Low) - -
897 Prediction (High) - -
954 Prediction (Low) - -
958 Prediction (Medium) - -
1032 Prediction (Low) - -
1078 Prediction (Medium) - -
1085 Prediction (Low) - -
1215 Prediction (Low) - -
1296 Experimental - 37611173
1501 Prediction (Low) - -
1529 Prediction (Medium) - -
1613 CYSMODDB SWISSPALM DBPTM Prediction (Low) - -
1636 CYSMODDB SWISSPALM DBPTM Prediction (Low) - -
2038 Prediction (Medium) - -
2092 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
252 C → F 0.001014 SNP Missense Mutation BRCA
350 F → delinsCCRNVI 0.002294 INS In Frame Ins OV
367 G → C 0.001764 SNP Missense Mutation LUAD
377 R → C 0.002020 SNP Missense Mutation PRAD
377 R → C 0.001887 SNP Missense Mutation UCEC
451 Y → C 0.001014 SNP Missense Mutation BRCA
736 C → S 0.002294 SNP Missense Mutation OV
770 R → C 0.002288 SNP Missense Mutation STAD
770 R → C 0.005435 SNP Missense Mutation ESCA
781 R → C 0.002288 SNP Missense Mutation STAD
835 W → C 0.002545 SNP Missense Mutation GBM
842 R → C 0.002506 SNP Missense Mutation COAD
868 C → C 0.003460 SNP Silent CESC
888 R → C 0.002141 SNP Missense Mutation SKCM
897 C → G 0.002294 SNP Missense Mutation OV
941 G → C 0.002545 SNP Missense Mutation GBM
1048 R → C 0.002506 SNP Missense Mutation COAD
1061 S → C 0.005435 SNP Missense Mutation ESCA
1102 Y → C 0.002288 SNP Missense Mutation STAD
1109 R → C 0.001887 SNP Missense Mutation UCEC
1529 C → C 0.002288 SNP Silent STAD
1738 R → C 0.001887 SNP Missense Mutation UCEC
1758 W → C 0.001887 SNP Missense Mutation UCEC
1887 G → C 0.002506 SNP Missense Mutation COAD
1948 R → C 0.001887 SNP Missense Mutation UCEC
2064 R → C 0.005660 SNP Missense Mutation UCEC
2143 Y → C 0.001764 SNP Missense Mutation LUAD
2152 F → C 0.002294 SNP Missense Mutation OV
2205 R → C 0.003460 SNP Missense Mutation CESC
868* C → ? 0.002033 SNP Nonsense Mutation LUSC