Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P27708 | CAD | Multifunctional protein CAD (Carbamoyl phosphate … | Homo sapiens (Human) | 2225 aa |
Protein Details: P27708 (CAD)
Protein Information
| Accession | P27708 |
|---|---|
| Protein Names | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] |
| Gene Symbol | CAD |
| Organism | Homo sapiens (Human) |
| Length | 2225 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 29733200 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAALVLEDGS11VLRGQPFGAA21VSTAGEVVFQ31TGMVGYPEAL41TDPSYKAQIL
51-10051VLTYPLIGNY61GIPPDEMDEF71GLCKWFESSG81IHVAALVVGE91CCPTPSHWSA
101-150101TRTLHEWLQQ111HGIPGLQGVD121TRELTKKLRE131QGSLLGKLVQ141NGTEPSSLPF
151-200151LDPNARPLVP161EVSIKTPRVF171NTGGAPRILA181LDCGLKYNQI191RCLCQRGAEV
201-250201TVVPWDHALD211SQEYEGLFLS221NGPGDPASYP231SVVSTLSRVL241SEPNPRPVFG
251-300251ICLGHQLLAL261AIGAKTYKMR271YGNRGHNQPC281LLVGSGRCFL291TSQNHGFAVE
301-350301TDSLPADWAP311LFTNANDGSN321EGIVHNSLPF331FSVQFHPEHQ341AGPSDMELLF
351-400351DIFLETVKEA361TAGNPGGQTV371RERLTERLCP381PGIPTPGSGL391PPPRKVLILG
401-450401SGGLSIGQAG411EFDYSGSQAI421KALKEENIQT431LLINPNIATV441QTSQGLADKV
451-500451YFLPITPHYV461TQVIRNERPD471GVLLTFGGQT481ALNCGVELTK491AGVLARYGVR
501-550501VLGTPVETIE511LTEDRRAFAA521RMAEIGEHVA531PSEAANSLEQ541AQAAAERLGY
551-600551PVLVRAAFAL561GGLGSGFASN571REELSALVAP581AFAHTSQVLV591DKSLKGWKEI
601-650601EYEVVRDAYG611NCVTVCNMEN621LDPLGIHTGE631SIVVAPSQTL641NDREYQLLRQ
651-700651TAIKVTQHLG661IVGECNVQYA671LNPESEQYYI681IEVNARLSRS691SALASKATGY
701-750701PLAYVAAKLA711LGIPLPELRN721SVTGGTAAFE731PSVDYCVVKI741PRWDLSKFLR
751-800751VSTKIGSCMK761SVGEVMGIGR771SFEEAFQKAL781RMVDENCVGF791DHTVKPVSDM
801-850801ELETPTDKRI811FVVAAALWAG821YSVDRLYELT831RIDRWFLHRM841KRIIAHAQLL
851-900851EQHRGQPLPP861DLLQQAKCLG871FSDKQIALAV881LSTELAVRKL891RQELGICPAV
901-950901KQIDTVAAEW911PAQTNYLYLT921YWGTTHDLTF931RTPHVLVLGS941GVYRIGSSVE
951-1000951FDWCAVGCIQ961QLRKMGYKTI971MVNYNPETVS981TDYDMCDRLY991FDEISFEVVM
1001-10501001DIYELENPEG1011VILSMGGQLP1021NNMAMALHRQ1031QCRVLGTSPE1041AIDSAENRFK
1051-11001051FSRLLDTIGI1061SQPQWRELSD1071LESARQFCQT1081VGYPCVVRPS1091YVLSGAAMNV
1101-11501101AYTDGDLERF1111LSSAAAVSKE1121HPVVISKFIQ1131EAKEIDVDAV1141ASDGVVAAIA
1151-12001151ISEHVENAGV1161HSGDATLVTP1171PQDITAKTLE1181RIKAIVHAVG1191QELQVTGPFN
1201-12501201LQLIAKDDQL1211KVIECNVRVS1221RSFPFVSKTL1231GVDLVALATR1241VIMGEEVEPV
1251-13001251GLMTGSGVVG1261VKVPQFSFSR1271LAGADVVLGV1281EMTSTGEVAG1291FGESRCEAYL
1301-13501301KAMLSTGFKI1311PKKNILLTIG1321SYKNKSELLP1331TVRLLESLGY1341SLYASLGTAD
1351-14001351FYTEHGVKVT1361AVDWHFEEAV1371DGECPPQRSI1381LEQLAEKNFE1391LVINLSMRGA
1401-14501401GGRRLSSFVT1411KGYRTRRLAA1421DFSVPLIIDI1431KCTKLFVEAL1441GQIGPAPPLK
1451-15001451VHVDCMTSQK1461LVRLPGLIDV1471HVHLREPGGT1481HKEDFASGTA1491AALAGGITMV
1501-15501501CAMPNTRPPI1511IDAPALALAQ1521KLAEAGARCD1531FALFLGASSE1541NAGTLGTVAG
1551-16001551SAAGLKLYLN1561ETFSELRLDS1571VVQWMEHFET1581WPSHLPIVAH1591AEQQTVAAVL
1601-16501601MVAQLTQRSV1611HICHVARKEE1621ILLIKAAKAR1631GLPVTCEVAP1641HHLFLSHDDL
1651-17001651ERLGPGKGEV1661RPELGSRQDV1671EALWENMAVI1681DCFASDHAPH1691TLEEKCGSRP
1701-17501701PPGFPGLETM1711LPLLLTAVSE1721GRLSLDDLLQ1731RLHHNPRRIF1741HLPPQEDTYV
1751-18001751EVDLEHEWTI1761PSHMPFSKAH1771WTPFEGQKVK1781GTVRRVVLRG1791EVAYIDGQVL
1801-18501801VPPGYGQDVR1811KWPQGAVPQL1821PPSAPATSEM1831TTTPERPRRG1841IPGLPDGRFH
1851-19001851LPPRIHRASD1861PGLPAEEPKE1871KSSRKVAEPE1881LMGTPDGTCY1891PPPPVPRQAS
1901-19501901PQNLGTPGLL1911HPQTSPLLHS1921LVGQHILSVQ1931QFTKDQMSHL1941FNVAHTLRMM
1951-20001951VQKERSLDIL1961KGKVMASMFY1971EVSTRTSSSF1981AAAMARLGGA1991VLSFSEATSS
2001-20502001VQKGESLADS2011VQTMSCYADV2021VVLRHPQPGA2031VELAAKHCRR2041PVINAGDGVG
2051-21002051EHPTQALLDI2061FTIREELGTV2071NGMTITMVGD2081LKHGRTVHSL2091ACLLTQYRVS
2101-21502101LRYVAPPSLR2111MPPTVRAFVA2121SRGTKQEEFE2131SIEEALPDTD2141VLYMTRIQKE
2151-22002151RFGSTQEYEA2161CFGQFILTPH2171IMTRAKKKMV2181VMHPMPRVNE2191ISVEVDSDPR
2201-22252201AAYFRQAENG2211MYIRMALLAT2221VLGRF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 73 | - | - | - |
Deep-Palm: 0.58
|
|
| 91 | - | - | - |
Deep-Palm: 0.56
|
|
| 92 | - | - | - |
Deep-Palm: 0.53
|
|
| 183 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.94
|
|
| 192 | - | - | - |
Deep-Palm: 0.96
|
|
| 194 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.91
|
|
| 252 | - | - | - |
Deep-Palm: 0.96
|
|
| 280 | - | - | - |
Deep-Palm: 0.40
|
|
| 288 | - | - | - |
Deep-Palm: 0.71
|
|
| 379 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.97
|
|
| 484 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.96
|
|
| 612 | - | - | - |
Deep-Palm: 0.12
|
|
| 616 | - | - | - |
Deep-Palm: 0.22
|
|
| 665 | - | - | - |
Deep-Palm: 0.62
|
|
| 736 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.93
|
|
| 758 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.91
|
|
| 787 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.75
|
|
| 868 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.97
|
|
| 897 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.98
|
|
| 954 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.84
|
|
| 958 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.43
|
|
| 986 | - | - | - |
Deep-Palm: 0.04
|
|
| 1032 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.80
|
|
| 1078 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.92
|
|
| 1085 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.93
|
|
| 1215 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.94
|
|
| 1296 | - |
HeLa
(37611173)
| - |
Deep-Palm: 0.72
|
|
| 1374 | - | - | - |
Deep-Palm: 0.85
|
|
| 1432 | - | - | - |
Deep-Palm: 0.93
|
|
| 1455 | - | - | - |
Deep-Palm: 0.95
|
|
| 1501 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.96
|
|
| 1529 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.98
|
|
| 1613 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.97
|
| 1636 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.98
|
| 1682 | - | - | - |
Deep-Palm: 0.35
|
|
| 1696 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.80
|
|
| 1889 | - | - | - |
Deep-Palm: 0.88
|
|
| 2016 | - | - | - |
Deep-Palm: 0.88
|
|
| 2038 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.95
|
|
| 2092 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.95
|
|
| 2161 | - | - | - |
Deep-Palm: 0.55
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
2
LNCaP
Specificity: 0.400
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.400
2/2 (100.0%)
1
HeLa cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 252 | C → F | 0.001014 | SNP | Missense Mutation | BRCA |
| 350 | F → delinsCCRNVI | 0.002294 | INS | In Frame Ins | OV |
| 367 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 377 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 377 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 451 | Y → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 736 | C → S | 0.002294 | SNP | Missense Mutation | OV |
| 770 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 770 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 781 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 835 | W → C | 0.002545 | SNP | Missense Mutation | GBM |
| 842 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 868 | C → C | 0.003460 | SNP | Silent | CESC |
| 888 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 897 | C → G | 0.002294 | SNP | Missense Mutation | OV |
| 941 | G → C | 0.002545 | SNP | Missense Mutation | GBM |
| 1048 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1061 | S → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 1102 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 1109 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1529 | C → C | 0.002288 | SNP | Silent | STAD |
| 1738 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1758 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1887 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1948 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 2064 | R → C | 0.005660 | SNP | Missense Mutation | UCEC |
| 2143 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 2152 | F → C | 0.002294 | SNP | Missense Mutation | OV |
| 2205 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 868* | C → ? | 0.002033 | SNP | Nonsense Mutation | LUSC |