Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P28271 | Aco1 | Cytoplasmic aconitate hydratase (Aconitase) (EC … | Mus musculus (Mouse) | 889 aa |
Protein Details: P28271 (Aco1)
Protein Information
| Accession | P28271 |
|---|---|
| Protein Names | Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) |
| Gene Symbol | Aco1 |
| Organism | Mus musculus (Mouse) |
| Length | 889 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 29660268 34884899 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MKNPFAHLAE11PLDAAQPGKR21FFNLNKLEDS31RYGRLPFSIR41VLLEAAVRNC
51-10051DEFLVKKNDI61ENILNWNVMQ71HKNIEVPFKP81ARVILQDFTG91VPAVVDFAAM
101-150101RDAVKKLGGN111PEKINPVCPA121DLVIDHSIQV131DFNRRADSLQ141KNQDLEFERN
151-200151KERFEFLKWG161SQAFCNMRII171PPGSGIIHQV181NLEYLARVVF191DQDGCYYPDS
201-250201LVGTDSHTTM211IDGLGVLGWG221VGGIEAEAVM231LGQPISMVLP241QVIGYKLMGK
251-300251PHPLVTSTDI261VLTITKHLRQ271VGVVGKFVEF281FGPGVAQLSI291ADRATIANMC
301-350301PEYGATAAFF311PVDEVSIAYL321LQTGREEDKV331KHIQKYLQAV341GMFRDFNDTS
351-400351QDPDFTQVVE361LDLKTVVPCC371SGPKRPQDKV381AVSEMKKDFE391SCLGAKQGFK
401-450401GFQVAPDRHN411DRKTFLYSNS421EFTLAHGSVV431IAAITSCTNT441SNPSVMLGAG
451-500451LLAKKAVEAG461LSVKPYIKTS471LSPGSGVVTY481YLRESGVMPY491LSQLGFDVVG
501-550501YGCMTCIGNS511GPLPEPVVEA521ITQGDLVAVG531VLSGNRNFEG541RVHPNTRANY
551-600551LASPPLVIAY561AIAGTVRIDF571EKEPLGVNAQ581GRQVFLKDIW591PTRDEIQAVE
601-650601RQHVIPGMFK611EVYQKIETVN621KSWNALAAPS631EKLYAWNPKS641TYIKSPPFFE
651-700651SLTLDLQPPK661SIVDAYVLLN671LGDSVTTDHI681SPAGNIARNS691PAARYLTNRG
701-750701LTPREFNSYG711SRRGNDAIMA721RGTFANIRLL731NKFLNKQAPQ741TVHLPSGETL
751-800751DVFDAAERYQ761QAGLPLIVLA771GKEYGSGSSR781DWAAKGPFLL791GIKAVLAESY
801-850801ERIHRSNLVG811MGVIPLEYLP821GETADSLGLT831GRERYTINIP841EDLKPRMTVQ
851-889851IKLDTGKTFQ861AVMRFDTDVE871LTYFHNGGIL881NYMIRKMAQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 50 | SWISSPALM DBPTM CYSMODDB | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 Aconitase/Iron-responsive element-binding protein 2 |
Liver
(28526873)
| - |
GPS-Palm: 0.89
Deep-Palm: 0.97
|
| 118 | - | - |
Brain
(35358180)
|
Deep-Palm: 0.91
|
|
| 165 | SWISSPALM DBPTM CYSMODDB | Aconitase family (aconitate hydratase) |
Liver
(28526873)
| - |
GPS-Palm: 0.87
Deep-Palm: 0.58
|
| 195 | - | - | - |
Deep-Palm: 0.36
|
|
| 300 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.68
|
|
| 369 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.94
|
|
| 370 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.93
|
|
| 392 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.96
|
|
| 437 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.94
|
|
| 503 | - | - | - |
Deep-Palm: 0.67
|
|
| 506 | - | - | - |
Deep-Palm: 0.92
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.833
5
Liver
Specificity: 0.333
5/5 (100.0%)
1
Brain
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
9
Brain tissue (Mass)
Specificity: 0.600
9/56 (16.1%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.