Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P29966 | MARCKS | Myristoylated alanine-rich C-kinase substrate (MARCKS) … | Homo sapiens (Human) | 332 aa |
Protein Details: P29966 (MARCKS)
Protein Information
| Accession | P29966 |
|---|---|
| Protein Names | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) |
| Gene Symbol | MARCKS |
| Organism | Homo sapiens (Human) |
| Length | 332 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 25914232 29733200 31251020 32944167 36430497 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGAQFSKTAA11KGEAAAERPG21EAAVASSPSK31ANGQENGHVK41VNGDASPAAA
51-10051ESGAKEELQA61NGSAPAADKE71EPAAAGSGAA81SPSAAEKGEP91AAAAAPEAGA
101-150101SPVEKEAPAE111GEAAEPGSPT121AAEGEAASAA131SSTSSPKAED141GATPSPSNET
151-200151PKKKKKRFSF161KKSFKLSGFS171FKKNKKEAGE181GGEAEAPAAE191GGKDEAAGGA
201-250201AAAAAEAGAA211SGEQAAAPGE221EAAAGEEGAA231GGDPQEAKPQ241EAAVAPEKPP
251-300251ASDETKAAEE261PSKVEEKKAE271EAGASAAACE281APSAAGPGAP291PEQEAAPAEE
301-332301PAAAAASSAC311AAPSQEAQPE321CSPEAPPAEA331AE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 279 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.98
|
|
| 310 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.94
|
|
| 321 | - | - | - |
Deep-Palm: 0.20
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.267
4
PC3
Specificity: 0.267
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
3
CEM 174 cell
Specificity: 0.200
3/3 (100.0%)
1
LNCaP
Specificity: 0.067
1/1 (100.0%)
1
HAP1 cell
Specificity: 0.067
1/1 (100.0%)
1
EC cell
Specificity: 0.067
1/1 (100.0%)
1
293T cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 167 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |