Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P29992 | GNA11 | Guanine nucleotide-binding protein subunit alpha-11 … | Homo sapiens (Human) | 359 aa |
Protein Details: P29992 (GNA11)
Protein Information
| Accession | P29992 |
|---|---|
| Protein Names | Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha) |
| Gene Symbol | GNA11 |
| Organism | Homo sapiens (Human) |
| Length | 359 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 22496122 24357059 26111759 29575903 29733200 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | PTMDCysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTLESMMACC11LSDEVKESKR21INAEIEKQLR31RDKRDARREL41KLLLLGTGES
51-10051GKSTFIKQMR61IIHGAGYSEE71DKRGFTKLVY81QNIFTAMQAM91IRAMETLKIL
101-150101YKYEQNKANA111LLIREVDVEK121VTTFEHQYVS131AIKTLWEDPG141IQECYDRRRE
151-200151YQLSDSAKYY161LTDVDRIATL171GYLPTQQDVL181RVRVPTTGII191EYPFDLENII
201-250201FRMVDVGGQR211SERRKWIHCF221ENVTSIMFLV231ALSEYDQVLV241ESDNENRMEE
251-300251SKALFRTIIT261YPWFQNSSVI271LFLNKKDLLE281DKILYSHLVD291YFPEFDGPQR
301-350301DAQAAREFIL311KMFVDLNPDS321DKIIYSHFTC331ATDTENIRFV341FAAVKDTILQ
351-359351LNLKEYNLV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 9 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.03
|
| 10 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.03
|
| 144 | SWISSPALM DBPTM CYSMODDB | G-protein alpha subunit |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.79
Deep-Palm: 0.88
|
| 219 | - | - | - |
Deep-Palm: 0.76
|
|
| 330 | - | - | - |
Deep-Palm: 0.16
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.267
4
cerebral cortex
Specificity: 0.222
4/4 (100.0%)
3
Primary T cell
Specificity: 0.167
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.111
2/2 (100.0%)
2
Jurkat T cell
Specificity: 0.111
2/2 (100.0%)
1
HeLa cell
Specificity: 0.056
1/1 (100.0%)
1
EC cell
Specificity: 0.056
1/1 (100.0%)
1
heart
Specificity: 0.056
1/1 (100.0%)
1
HUVECs
Specificity: 0.056
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.167
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 101 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 183 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 183 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 183 | R → C | 0.012500 | SNP | Missense Mutation | UVM |