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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P29992 GNA11; GA11 Guanine nucleotide-binding protein subunit alpha-11 … Homo sapiens (Human) 359 aa

Protein Details: P29992 (GNA11)

Protein Information
Accession P29992
Protein Names Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha)
Gene Symbol GNA11; GA11
Organism Homo sapiens (Human)
Length 359 aa
Isoforms No isoforms
Related PMIDs 19137006 19801377 22496122 24357059 26111759 29575903 29733200 32944167 33636221 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.303
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
10
HAP1 cells
Specificity: 0.303
10/10 (100.0%)
6
Jurkat T cells
Specificity: 0.182
6/25 (24.0%)
4
PC3 cells
Specificity: 0.121
4/4 (100.0%)
4
Cerebral cortex
Specificity: 0.121
4/4 (100.0%)
3
T cells
Specificity: 0.091
3/4 (75.0%)
2
DU145 cells
Specificity: 0.061
2/2 (100.0%)
2
Endothelial cells
Specificity: 0.061
2/2 (100.0%)
1
HeLa cells
Specificity: 0.030
1/1 (100.0%)
1
Liver membrane
Specificity: 0.030
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MTLESMMACC11LSDEVKESKR21INAEIEKQLR31RDKRDARREL41KLLLLGTGES
51-10051GKSTFIKQMR61IIHGAGYSEE71DKRGFTKLVY81QNIFTAMQAM91IRAMETLKIL
101-150101YKYEQNKANA111LLIREVDVEK121VTTFEHQYVS131AIKTLWEDPG141IQECYDRRRE
151-200151YQLSDSAKYY161LTDVDRIATL171GYLPTQQDVL181RVRVPTTGII191EYPFDLENII
201-250201FRMVDVGGQR211SERRKWIHCF221ENVTSIMFLV231ALSEYDQVLV241ESDNENRMEE
251-300251SKALFRTIIT261YPWFQNSSVI271LFLNKKDLLE281DKILYSHLVD291YFPEFDGPQR
301-350301DAQAAREFIL311KMFVDLNPDS321DKIIYSHFTC331ATDTENIRFV341FAAVKDTILQ
351-359351LNLKEYNLV
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
9 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) - 19801377
10 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) - 19801377
144 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) G-protein alpha subunit 29575903
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
101 Y → C 0.002506 SNP Missense Mutation COAD
183 R → C 0.001764 SNP Missense Mutation LUAD
183 R → C 0.002141 SNP Missense Mutation SKCM
183 R → C 0.012500 SNP Missense Mutation UVM