Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P30041 | PRDX6 | Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) … | Homo sapiens (Human) | 224 aa |
Protein Details: P30041 (PRDX6)
Protein Information
| Accession | P30041 |
|---|---|
| Protein Names | Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12) |
| Gene Symbol | PRDX6 |
| Organism | Homo sapiens (Human) |
| Length | 224 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 24357059 29733200 31251020 31382980 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | PTMDSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPGGLLLGDV11APNFEANTTV21GRIRFHDFLG31DSWGILFSHP41RDFTPVCTTE
51-10051LGRAAKLAPE61FAKRNVKLIA71LSIDSVEDHL81AWSKDINAYN91CEEPTEKLPF
101-150101PIIDDRNREL111AILLGMLDPA121EKDEKGMPVT131ARVVFVFGPD141KKLKLSILYP
151-200151ATTGRNFDEI161LRVVISLQLT171AEKRVATPVD181WKDGDSVMVL191PTIPEEEAKK
201-224201LFPKGVFTKE211LPSGKKYLRY221TPQP
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 47 | PTMD | Thioredoxin-like superfamily Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant AhpC/TSA family Glutaredoxin | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.96
|
| 91 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.11
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.308
4
cerebral cortex
Specificity: 0.235
4/4 (100.0%)
3
PC3
Specificity: 0.176
3/3 (100.0%)
1
LNCaP
Specificity: 0.059
1/1 (100.0%)
1
U937 cell
Specificity: 0.059
1/1 (100.0%)
1
EC cell
Specificity: 0.059
1/1 (100.0%)
1
293T cell
Specificity: 0.059
1/1 (100.0%)
1
heart
Specificity: 0.059
1/1 (100.0%)
1
HUVECs
Specificity: 0.059
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.235
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 24 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 132 | R → C | 0.002506 | SNP | Missense Mutation | COAD |