Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P30153 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa … | Homo sapiens (Human) | 589 aa |
Protein Details: P30153 (PPP2R1A)
Protein Information
| Accession | P30153 |
|---|---|
| Protein Names | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) |
| Gene Symbol | PPP2R1A |
| Organism | Homo sapiens (Human) |
| Length | 589 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 29733200 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAADGDDSL11YPIAVLIDEL21RNEDVQLRLN31SIKKLSTIAL41ALGVERTRSE
51-10051LLPFLTDTIY61DEDEVLLALA71EQLGTFTTLV81GGPEYVHCLL91PPLESLATVE
101-150101ETVVRDKAVE111SLRAISHEHS121PSDLEAHFVP131LVKRLAGGDW141FTSRTSACGL
151-200151FSVCYPRVSS161AVKAELRQYF171RNLCSDDTPM181VRRAAASKLG191EFAKVLELDN
201-250201VKSEIIPMFS211NLASDEQDSV221RLLAVEACVN231IAQLLPQEDL241EALVMPTLRQ
251-300251AAEDKSWRVR261YMVADKFTEL271QKAVGPEITK281TDLVPAFQNL291MKDCEAEVRA
301-350301AASHKVKEFC311ENLSADCREN321VIMSQILPCI331KELVSDANQH341VKSALASVIM
351-400351GLSPILGKDN361TIEHLLPLFL371AQLKDECPEV381RLNIISNLDC391VNEVIGIRQL
401-450401SQSLLPAIVE411LAEDAKWRVR421LAIIEYMPLL431AGQLGVEFFD441EKLNSLCMAW
451-500451LVDHVYAIRE461AATSNLKKLV471EKFGKEWAHA481TIIPKVLAMS491GDPNYLHRMT
501-550501TLFCINVLSE511VCGQDITTKH521MLPTVLRMAG531DPVANVRFNV541AKSLQKIGPI
551-589551LDNSTLQSEV561KPILEKLTQD571QDVDVKYFAQ581EALTVLSLA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 88 | - | - | - |
Deep-Palm: 0.98
|
|
| 148 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.94
|
|
| 154 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.81
Deep-Palm: 0.90
|
|
| 174 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 228 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.96
|
|
| 294 | - | - | - |
Deep-Palm: 0.94
|
|
| 310 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.90
|
|
| 317 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.44
|
|
| 329 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.77
|
|
| 377 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.81
Deep-Palm: 0.95
|
|
| 390 | SWISSPALM DBPTM CYSMODDB | - |
SW480 cell line
(26865113)
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.90
Deep-Palm: 0.87
|
| 447 | - | - | - |
Deep-Palm: 0.77
|
|
| 504 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.68
Deep-Palm: 0.26
|
|
| 512 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.66
Deep-Palm: 0.37
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
2
LNCaP
Specificity: 0.154
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.077
1/1 (100.0%)
1
EC cell
Specificity: 0.077
1/1 (100.0%)
1
293T cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
Cerebral Cortex (Mass)
Specificity: 0.231
3/4 (75.0%)
1
LNCaP cells (Mass)
Specificity: 0.077
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 28 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 111 | S → C | 0.002545 | SNP | Missense Mutation | GBM |
| 144 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 148 | C → C | 0.001887 | SNP | Silent | UCEC |
| 148 | C → Y | 0.005435 | SNP | Missense Mutation | ESCA |
| 257 | W → C | 0.002294 | SNP | Missense Mutation | OV |
| 258 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 329 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 377 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 456 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 459 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 459 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 480 | A → Cfs*31 | 0.001969 | INS | Frame Shift Ins | HNSC |