Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P30153 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa … | Homo sapiens (Human) | 589 aa |
Protein Details: P30153 (PPP2R1A)
Protein Information
| Accession | P30153 |
|---|---|
| Protein Names | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) |
| Gene Symbol | PPP2R1A |
| Organism | Homo sapiens (Human) |
| Length | 589 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 22496122 29733200 31251020 32944167 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.533
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
24
LNCaP cells
Specificity: 0.533
24/46 (52.2%)
10
HAP1 cells
Specificity: 0.222
10/10 (100.0%)
4
PC3 cells
Specificity: 0.089
4/4 (100.0%)
4
293T cells
Specificity: 0.089
4/10 (40.0%)
2
Jurkat T cells
Specificity: 0.044
2/25 (8.0%)
1
Endothelial cells
Specificity: 0.022
1/2 (50.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAAADGDDSL11YPIAVLIDEL21RNEDVQLRLN31SIKKLSTIAL41ALGVERTRSE
51-10051LLPFLTDTIY61DEDEVLLALA71EQLGTFTTLV81GGPEYVHCLL91PPLESLATVE
101-150101ETVVRDKAVE111SLRAISHEHS121PSDLEAHFVP131LVKRLAGGDW141FTSRTSACGL
151-200151FSVCYPRVSS161AVKAELRQYF171RNLCSDDTPM181VRRAAASKLG191EFAKVLELDN
201-250201VKSEIIPMFS211NLASDEQDSV221RLLAVEACVN231IAQLLPQEDL241EALVMPTLRQ
251-300251AAEDKSWRVR261YMVADKFTEL271QKAVGPEITK281TDLVPAFQNL291MKDCEAEVRA
301-350301AASHKVKEFC311ENLSADCREN321VIMSQILPCI331KELVSDANQH341VKSALASVIM
351-400351GLSPILGKDN361TIEHLLPLFL371AQLKDECPEV381RLNIISNLDC391VNEVIGIRQL
401-450401SQSLLPAIVE411LAEDAKWRVR421LAIIEYMPLL431AGQLGVEFFD441EKLNSLCMAW
451-500451LVDHVYAIRE461AATSNLKKLV471EKFGKEWAHA481TIIPKVLAMS491GDPNYLHRMT
501-550501TLFCINVLSE511VCGQDITTKH521MLPTVLRMAG531DPVANVRFNV541AKSLQKIGPI
551-589551LDNSTLQSEV561KPILEKLTQD571QDVDVKYFAQ581EALTVLSLA
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 148 | Prediction (Low) | - | - |
| 154 | Prediction (Medium) | - | - |
| 174 | Prediction (Medium) | - | - |
| 228 | Prediction (Low) | - | - |
| 329 | Prediction (Medium) | - | - |
| 377 | Prediction (Medium) | - | - |
| 390 | CYSMODDB SWISSPALM DBPTM Prediction (High) | - | - |
| 504 | Experimental Prediction (Low) | - | 37611173 |
| 512 | Experimental Prediction (Low) | HEAT repeat | 37611173 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 28 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 111 | S → C | 0.002545 | SNP | Missense Mutation | GBM |
| 144 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 148 | C → C | 0.001887 | SNP | Silent | UCEC |
| 148 | C → Y | 0.005435 | SNP | Missense Mutation | ESCA |
| 257 | W → C | 0.002294 | SNP | Missense Mutation | OV |
| 258 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 329 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 377 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 456 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 459 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 459 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 480 | A → Cfs*31 | 0.001969 | INS | Frame Shift Ins | HNSC |