Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P30825 | SLC7A1 | High affinity cationic amino acid … | Homo sapiens (Human) | 629 aa |
Protein Details: P30825 (SLC7A1)
Protein Information
| Accession | P30825 |
|---|---|
| Protein Names | High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) |
| Gene Symbol | SLC7A1 |
| Organism | Homo sapiens (Human) |
| Length | 629 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 29733200 31251020 32651440 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGCKVLLNIG11QQMLRRKVVD21CSREETRLSR31CLNTFDLVAL41GVGSTLGAGV
51-10051YVLAGAVARE61NAGPAIVISF71LIAALASVLA81GLCYGEFGAR91VPKTGSAYLY
101-150101SYVTVGELWA111FITGWNLILS121YIIGTSSVAR131AWSATFDELI141GRPIGEFSRT
151-200151HMTLNAPGVL161AENPDIFAVI171IILILTGLLT181LGVKESAMVN191KIFTCINVLV
201-250201LGFIMVSGFV211KGSVKNWQLT221EEDFGNTSGR231LCLNNDTKEG241KPGVGGFMPF
251-300251GFSGVLSGAA261TCFYAFVGFD271CIATTGEEVK281NPQKAIPVGI291VASLLICFIA
301-350301YFGVSAALTL311MMPYFCLDNN321SPLPDAFKHV331GWEGAKYAVA341VGSLCALSAS
351-400351LLGSMFPMPR361VIYAMAEDGL371LFKFLANVND381RTKTPIIATL391ASGAVAAVMA
401-450401FLFDLKDLVD411LMSIGTLLAY421SLVAACVLVL431RYQPEQPNLV441YQMASTSDEL
451-500451DPADQNELAS461TNDSQLGFLP471EAEMFSLKTI481LSPKNMEPSK491ISGLIVNIST
501-550501SLIAVLIITF511CIVTVLGREA521LTKGALWAVF531LLAGSALLCA541VVTGVIWRQP
551-600551ESKTKLSFKV561PFLPVLPILS571IFVNVYLMMQ581LDQGTWVRFA591VWMLIGFIIY
601-629601FGYGLWHSEE611ASLDADQART621PDGNLDQCK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.97
Deep-Palm: 0.03
|
| 21 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.88
|
|
| 31 | INNER MEMBRANE TRANSPORTER YGJI-RELATED | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.96
|
|
| 83 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.98
|
|
| 195 | - | - | - |
Deep-Palm: 0.79
|
|
| 232 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.87
|
|
| 262 | - | - | - |
Deep-Palm: 0.18
|
|
| 271 | - | - | - |
Deep-Palm: 0.64
|
|
| 297 | - | - | - |
Deep-Palm: 0.82
|
|
| 316 | - | - | - |
Deep-Palm: 0.58
|
|
| 345 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.97
|
|
| 426 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.98
|
|
| 511 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.90
|
|
| 539 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.97
|
|
| 628 | - |
HeLa
(29575903)
|
LNCaP
(31251020)
|
GPS-Palm: 0.96
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
5
Jurkat T cell
Specificity: 0.385
5/5 (100.0%)
4
LNCaP
Specificity: 0.308
4/4 (100.0%)
1
HAP1 cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP cells (Mass)
Specificity: 0.231
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 59 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 232 | C → G | 0.002294 | SNP | Missense Mutation | OV |
| 302 | F → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 501 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |