Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P31645 | SLC6A4 | Sodium-dependent serotonin transporter (SERT) (5HT … | Homo sapiens (Human) | 630 aa |
Protein Details: P31645 (SLC6A4)
Protein Information
| Accession | P31645 |
|---|---|
| Protein Names | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) |
| Gene Symbol | SLC6A4 |
| Organism | Homo sapiens (Human) |
| Length | 630 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | PTMDSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501METTPLNSQK11QLSACEDGED21CQENGVLQKV31VPTPGDKVES41GQISNGYSAV
51-10051PSPGAGDDTR61HSIPATTTTL71VAELHQGERE81TWGKKVDFLL91SVIGYAVDLG
101-150101NVWRFPYICY111QNGGGAFLLP121YTIMAIFGGI131PLFYMELALG141QYHRNGCISI
151-200151WRKICPIFKG161IGYAICIIAF171YIASYYNTIM181AWALYYLISS191FTDQLPWTSC
201-250201KNSWNTGNCT211NYFSEDNITW221TLHSTSPAEE231FYTRHVLQIH241RSKGLQDLGG
251-300251ISWQLALCIM261LIFTVIYFSI271WKGVKTSGKV281VWVTATFPYI291ILSVLLVRGA
301-350301TLPGAWRGVL311FYLKPNWQKL321LETGVWIDAA331AQIFFSLGPG341FGVLLAFASY
351-400351NKFNNNCYQD361ALVTSVVNCM371TSFVSGFVIF381TVLGYMAEMR391NEDVSEVAKD
401-450401AGPSLLFITY411AEAIANMPAS421TFFAIIFFLM431LITLGLDSTF441AGLEGVITAV
451-500451LDEFPHVWAK461RRERFVLAVV471ITCFFGSLVT481LTFGGAYVVK491LLEEYATGPA
501-550501VLTVALIEAV511AVSWFYGITQ521FCRDVKEMLG531FSPGWFWRIC541WVAISPLFLL
551-600551FIICSFLMSP561PQLRLFQYNY571PYWSIILGYC581IGTSSFICIP591TYIAYRLIIT
601-630601PGTFKERIIK611SITPETPTEI621PCGDIRLNAV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 15 | - | - | - |
Deep-Palm: 0.66
|
|
| 21 | - | - | - |
Deep-Palm: 0.61
|
|
| 109 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.88
|
|
| 147 | SWISSPALM | Sodium:neurotransmitter symporter family | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.80
|
| 155 | SWISSPALM | Sodium:neurotransmitter symporter family | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.59
|
| 166 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.23
|
|
| 200 | - | - | - |
Deep-Palm: 0.03
|
|
| 209 | - | - | - |
Deep-Palm: 0.02
|
|
| 258 | - | - | - |
Deep-Palm: 0.59
|
|
| 357 | - | - | - |
Deep-Palm: 0.10
|
|
| 369 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.04
|
|
| 473 | - | - | - |
Deep-Palm: 0.72
|
|
| 522 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.39
|
|
| 540 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.60
|
|
| 554 | - | - | - |
Deep-Palm: 0.53
|
|
| 580 | - | - | - |
Deep-Palm: 0.03
|
|
| 588 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.07
|
|
| 622 | - | - | - |
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 185 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 197 | W → C | 0.003460 | SNP | Missense Mutation | CESC |
| 234 | R → C | 0.002294 | SNP | Missense Mutation | OV |
| 293 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 473 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 607 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 626 | R → C | 0.002288 | SNP | Missense Mutation | STAD |