Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P31939-2 | ATIC | Bifunctional purine biosynthesis protein ATIC … | Homo sapiens (Human) | 591 aa |
Protein Details: P31939-2 (ATIC)
Protein Information
| Accession | P31939-2 |
|---|---|
| Protein Names | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] |
| Gene Symbol | ATIC |
| Organism | Homo sapiens (Human) |
| Length | 591 aa |
| Isoforms | |
| Related PMIDs | 31251020 33636221 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSSLSALFSV11SDKTGLVEFA21RNLTALGLNL31VASGGTAKAL41RDAGLAVRDV
51-10051SELTGFPEML61GGRVKTLHPA71VHAGILARNI81PEDNADMARL91DFNLIRVVAC
101-150101NLYPFVKTVA111SPGVTVEEAV121EQIDIGGVTL131LRAAAKNHAR141VTVVCEPEDY
151-200151VVVSTEMQSS161ESKDTSLETR171RQLALKAFTH181TAQYDEAISD191YFRKQYSKGV
201-250201SQMPLRYGMN211PHQTPAQLYT221LQPKLPITVL231NGAPGFINLC241DALNAWQLVK
251-300251ELKEALGIPA261AASFKHVSPA271GAAVGIPLSE281DEAKVCMVYD291LYKTLTPISA
301-350301AYARARGADR311MSSFGDFVAL321SDVCDVPTAK331IISREVSDGI341IAPGYEEEAL
351-400351TILSKKKNGN361YCVLQMDQSY371KPDENEVRTL381FGLHLSQKRN391NGVVDKSLFS
401-450401NVVTKNKDLP411ESALRDLIVA421TIAVKYTQSN431SVCYAKNGQV441IGIGAGQQSR
451-500451IHCTRLAGDK461ANYWWLRHHP471QVLSMKFKTG481VKRAEISNAI491DQYVTGTIGE
501-550501DEDLIKWKAL511FEEVPELLTE521AEKKEWVEKL531TEVSISSDAF541FPFRDNVDRA
551-591551KRSGVAYIAA561PSGSAADKVV571IEACDELGII581LAHTNLRLFH591H
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 100 | - | - | - |
GPS-Palm: 0.72
|
|
| 101 | - | - | - |
Deep-Palm: 0.88
|
|
| 146 | - | - | - |
Deep-Palm: 0.91
|
|
| 240 | - |
HeLa
(29575903)
| - | - | |
| 241 | - | - | - |
Deep-Palm: 0.96
|
|
| 286 | - | - | - |
GPS-Palm: 0.80
|
|
| 287 | - | - | - |
Deep-Palm: 0.96
|
|
| 324 | - | - | - |
GPS-Palm: 0.82
|
|
| 325 | - | - | - |
Deep-Palm: 0.78
|
|
| 362 | - | - | - |
GPS-Palm: 0.84
|
|
| 363 | - | - | - |
Deep-Palm: 0.59
|
|
| 433 | - | - | - |
GPS-Palm: 0.68
|
|
| 434 | - | - | - |
Deep-Palm: 0.79
|
|
| 453 | - | - | - |
GPS-Palm: 0.83
|
|
| 454 | - | - | - |
Deep-Palm: 0.80
|
|
| 574 | - | - | - |
GPS-Palm: 0.75
|
|
| 575 | - | - | - |
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.571
4/4 (100.0%)
2
LNCaP
Specificity: 0.286
2/2 (100.0%)
1
heart
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 197 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 241 | C → C | 0.002288 | SNP | Silent | STAD |
| 241 | C → C | 0.001887 | SNP | Silent | UCEC |
| 564 | G → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 575 | C → C | 0.003460 | SNP | Silent | CESC |