Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P33991 | MCM4; CDC21 | DNA replication licensing factor MCM4 … | Homo sapiens (Human) | 863 aa |
Protein Details: P33991 (MCM4)
Protein Information
| Accession | P33991 |
|---|---|
| Protein Names | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) |
| Gene Symbol | MCM4; CDC21 |
| Organism | Homo sapiens (Human) |
| Length | 863 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 29733200 31251020 31382980 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.261
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
6
Jurkat T cells
Specificity: 0.261
6/25 (24.0%)
6
LNCaP cells
Specificity: 0.261
6/46 (13.0%)
6
HAP1 cells
Specificity: 0.261
6/10 (60.0%)
4
293T cells
Specificity: 0.174
4/10 (40.0%)
1
U937 cells
Specificity: 0.043
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSSPASTPSR11RGSRRGRATP21AQTPRSEDAR31SSPSQRRRGE41DSTSTGELQP
51-10051MPTSPGVDLQ61SPAAQDVLFS71SPPQMHSSAI81PLDFDVSSPL91TYGTPSSRVE
101-150101GTPRSGVRGT111PVRQRPDLGS121AQKGLQVDLQ131SDGAAAEDIV141ASEQSLGQKL
151-200151VIWGTDVNVA161ACKENFQRFL171QRFIDPLAKE181EENVGIDITE191PLYMQRLGEI
201-250201NVIGEPFLNV211NCEHIKSFDK221NLYRQLISYP231QEVIPTFDMA241VNEIFFDRYP
251-300251DSILEHQIQV261RPFNALKTKN271MRNLNPEDID281QLITISGMVI291RTSQLIPEMQ
301-350301EAFFQCQVCA311HTTRVEMDRG321RIAEPSVCGR331CHTTHSMALI341HNRSLFSDKQ
351-400351MIKLQESPED361MPAGQTPHTV371ILFAHNDLVD381KVQPGDRVNV391TGIYRAVPIR
401-450401VNPRVSNVKS411VYKTHIDVIH421YRKTDAKRLH431GLDEEAEQKL441FSEKRVELLK
451-500451ELSRKPDIYE461RLASALAPSI471YEHEDIKKGI481LLQLFGGTRK491DFSHTGRGKF
501-550501RAEINILLCG511DPGTSKSQLL521QYVYNLVPRG531QYTSGKGSSA541VGLTAYVMKD
551-600551PETRQLVLQT561GALVLSDNGI571CCIDEFDKMN581ESTRSVLHEV591MEQQTLSIAK
601-650601AGIICQLNAR611TSVLAAANPI621ESQWNPKKTT631IENIQLPHTL641LSRFDLIFLL
651-700651LDPQDEAYDR661RLAHHLVALY671YQSEEQAEEE681LLDMAVLKDY691IAYAHSTIMP
701-750701RLSEEASQAL711IEAYVDMRKI721GSSRGMVSAY731PRQLESLIRL741AEAHAKVRLS
751-800751NKVEAIDVEE761AKRLHREALK771QSATDPRTGI781VDISILTTGM791SATSRKRKEE
801-850801LAEALKKLIL811SKGKTPALKY821QQLFEDIRGQ831SDIAITKDMF841EEALRALADD
851-863851DFLTVTGKTV861RLL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 162 | Prediction (Medium) | - | - |
| 212 | Prediction (Low) | - | - |
| 328 | Prediction (Medium) | - | - |
| 509 | Prediction (High) | - | - |
| 571 | Prediction (Low) | - | - |
| 605 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 32 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 39 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 92 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 172 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 328 | C → C | 0.004577 | SNP | Silent | STAD |
| 328 | C → C | 0.002506 | SNP | Silent | COAD |
| 330 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 343 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 571 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 741 | A → delinsVLGFFVCFFET | 0.002294 | INS | In Frame Ins | OV |
| 772 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 861 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 571* | C → ? | 0.001969 | SNP | Nonsense Mutation | LGG |