Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P35222 CTNNB1; CTNNB; OK/SW-cl.35; PRO2286 Catenin beta-1 (Beta-catenin) Homo sapiens (Human) 781 aa

Protein Details: P35222 (CTNNB1)

Protein Information
Accession P35222
Protein Names Catenin beta-1 (Beta-catenin)
Gene Symbol CTNNB1; CTNNB; OK/SW-cl.35; PRO2286
Organism Homo sapiens (Human)
Length 781 aa
Isoforms No isoforms
Related PMIDs 19801377 29733200 31251020 32944167 33636221 37611173
Database Sources CysModDB dbPTM PTMD SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.643
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.643
36/46 (78.3%)
10
HAP1 cells
Specificity: 0.179
10/10 (100.0%)
4
PC3 cells
Specificity: 0.071
4/4 (100.0%)
4
293T cells
Specificity: 0.071
4/10 (40.0%)
1
DU145 cells
Specificity: 0.018
1/2 (50.0%)
1
Liver membrane
Specificity: 0.018
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MATQADLMEL11DMAMEPDRKA21AVSHWQQQSY31LDSGIHSGAT41TTAPSLSGKG
51-10051NPEEEDVDTS61QVLYEWEQGF71SQSFTQEQVA81DIDGQYAMTR91AQRVRAAMFP
101-150101ETLDEGMQIP111STQFDAAHPT121NVQRLAEPSQ131MLKHAVVNLI141NYQDDAELAT
151-200151RAIPELTKLL161NDEDQVVVNK171AAVMVHQLSK181KEASRHAIMR191SPQMVSAIVR
201-250201TMQNTNDVET211ARCTAGTLHN221LSHHREGLLA231IFKSGGIPAL241VKMLGSPVDS
251-300251VLFYAITTLH261NLLLHQEGAK271MAVRLAGGLQ281KMVALLNKTN291VKFLAITTDC
301-350301LQILAYGNQE311SKLIILASGG321PQALVNIMRT331YTYEKLLWTT341SRVLKVLSVC
351-400351SSNKPAIVEA361GGMQALGLHL371TDPSQRLVQN381CLWTLRNLSD391AATKQEGMEG
401-450401LLGTLVQLLG411SDDINVVTCA421AGILSNLTCN431NYKNKMMVCQ441VGGIEALVRT
451-500451VLRAGDREDI461TEPAICALRH471LTSRHQEAEM481AQNAVRLHYG491LPVVVKLLHP
501-550501PSHWPLIKAT511VGLIRNLALC521PANHAPLREQ531GAIPRLVQLL541VRAHQDTQRR
551-600551TSMGGTQQQF561VEGVRMEEIV571EGCTGALHIL581ARDVHNRIVI591RGLNTIPLFV
601-650601QLLYSPIENI611QRVAAGVLCE621LAQDKEAAEA631IEAEGATAPL641TELLHSRNEG
651-700651VATYAAAVLF661RMSEDKPQDY671KKRLSVELTS681SLFRTEPMAW691NETADLGLDI
701-750701GAQGEPLGYR711QDDPSYRSFH721SGGYGQDALG731MDPMMEHEMG741GHHPGADYPV
751-781751DGLPDLGHAQ761DLMDGLPPGD771SNQLAWFDTD781L
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
300 PTMD Prediction (Low) - -
350 Prediction (High) - -
381 Prediction (High) - -
429 Experimental Prediction (Low) Armadillo/beta-catenin-like repeat 37611173
439 Prediction (Low) - -
466 CYSMODDB SWISSPALM PTMD DBPTM Prediction (High) - -
520 Prediction (High) - -
573 Prediction (High) - -
619 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
33 S → C 0.010989 SNP Missense Mutation LIHC
33 S → C 0.002020 SNP Missense Mutation PRAD
33 S → C 0.016981 SNP Missense Mutation UCEC
37 S → C 0.004577 SNP Missense Mutation STAD
37 S → C 0.001764 SNP Missense Mutation LUAD
37 S → C 0.002747 SNP Missense Mutation LIHC
37 S → C 0.002427 SNP Missense Mutation BLCA
37 S → C 0.013208 SNP Missense Mutation UCEC
37 S → C 0.003460 SNP Missense Mutation CESC
45 S → C 0.002141 SNP Missense Mutation SKCM
45 S → C 0.001887 SNP Missense Mutation UCEC
124 R → C 0.001887 SNP Missense Mutation UCEC
151 R → C 0.002288 SNP Missense Mutation STAD
151 R → C 0.001969 SNP Missense Mutation HNSC
213 C → F 0.001764 SNP Missense Mutation LUAD
225 R → C 0.001887 SNP Missense Mutation UCEC
383 W → C 0.002747 SNP Missense Mutation LIHC
383 W → C 0.001887 SNP Missense Mutation UCEC
419 C → Sfs*6 0.002747 DEL Frame Shift Del LIHC
425 S → C 0.003460 SNP Missense Mutation CESC
429 C → G 0.002141 SNP Missense Mutation SKCM
439 C → C 0.001887 SNP Silent UCEC
619 C → Y 0.002506 SNP Missense Mutation COAD
619 C → Y 0.005618 SNP Missense Mutation PAAD
646 S → C 0.003460 SNP Missense Mutation CESC
710 R → C 0.002288 SNP Missense Mutation STAD
716 Y → C 0.002033 SNP Missense Mutation THCA