Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P35609-2 | ACTN2 | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform … | Homo sapiens (Human) | 894 aa |
Protein Details: P35609-2 (ACTN2)
Protein Information
| Accession | P35609-2 |
|---|---|
| Protein Names | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) |
| Gene Symbol | ACTN2 |
| Organism | Homo sapiens (Human) |
| Length | 894 aa |
| Isoforms | |
| Related PMIDs | 31251020 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MNQIEPGVQY11NYVYDEDEYM21IQEEEWDRDL31LLDPAWEKQQ41RKTFTAWCNS
51-10051HLRKAGTQIE61NIEEDFRNGL71KLMLLLEVIS81GERLPKPDRG91KMRFHKIANV
101-150101NKALDYIASK111GVKLVSIGAE121EIVDGNVKMT131LGMIWTIILR141FAIQDISVEE
151-200151TSAKEGLLLW161CQRKTAPYRN171VNIQNFHTSW181KDGLGLCALI191HRHRPDLIDY
201-250201SKLNKDDPIG211NINLAMEIAE221KHLDIPKMLD231AEDLVYTARP241DERAIMTYVS
251-300251CYYHAFAGAQ261KAETAANRIC271KVLAVNQENE281RLMEEYERLA291SELLEWIRRT
301-350301IPWLENRTPE311KTMQAMQKKL321EDFRDYRRKH331KPPKVQEKCQ341LEINFNTLQT
351-400351KLRISNRPAF361MPSEGKMVSD371IAGAWQRLEQ381AEKGYEEWLL391NEIRRLERLE
401-450401HLAEKFRQKA411STHETWAYGK421EQILLQKDYE431SASLTEVRAL441LRKHEAFESD
451-500451LAAHQDRVEQ461IAAIAQELNE471LDYHDAVNVN481DRCQKICDQW491DRLGTLTQKR
501-550501REALERMEKL511LETIDQLHLE521FAKRAAPFNN531WMEGAMEDLQ541DMFIVHSIEE
551-600551IQSLITAHEQ561FKATLPEADG571ERQSIMAIQN581EVEKVIQSYN591IRISSSNPYS
601-650601TVTMDELRTK611WDKVKQLVPI621RDQSLQEELA631RQHANERLRR641QFAAQANAIG
651-700651PWIQNKMEEI661ARSSIQITGA671LEDQMNQLKQ681YEHNIINYKN691NIDKLEGDHQ
701-750701LIQEALVFDN711KHTNYTMEHI721RVGWELLLTT731IARTINEVET741QILTRDAKGI
751-800751TQEQMNEFRA761SFNHFDRRKN771GLMDHEDFRA781CLISMGYDLG791EAEFARIMTL
801-850801VDPNGQGTVT811FQSFIDFMTR821ETADTDTAEQ831VIASFRILAS841DKPYILAEEL
851-894851RRELPPDQAQ861YCIKRMPAYS871GPGSVPGALD881YAAFSSALYG891ESDL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 48 | Calponin homology domain CH domain superfamily | - | - |
Deep-Palm: 0.72
|
|
| 161 | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.96
Deep-Palm: 0.96
|
|
| 187 | - | - | - |
Deep-Palm: 0.86
|
|
| 251 | - | - | - |
Deep-Palm: 0.75
|
|
| 270 | - | - | - |
Deep-Palm: 0.95
|
|
| 339 | - | - | - |
Deep-Palm: 0.73
|
|
| 483 | - | - | - |
Deep-Palm: 0.24
|
|
| 487 | - | - | - |
Deep-Palm: 0.34
|
|
| 781 | - | - | - |
Deep-Palm: 0.52
|
|
| 862 | - | - | - |
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 1.000
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 132 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 180 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 187 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 250 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 298 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 298 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 355 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 398 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 398 | R → C | 0.017544 | SNP | Missense Mutation | UCS |
| 457 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 596 | S → C | 0.002288 | SNP | Missense Mutation | STAD |
| 637 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 721 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |