Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P36578 | RPL4 | Large ribosomal subunit protein uL4 … | Homo sapiens (Human) | 427 aa |
Protein Details: P36578 (RPL4)
Protein Information
| Accession | P36578 |
|---|---|
| Protein Names | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) |
| Gene Symbol | RPL4 |
| Organism | Homo sapiens (Human) |
| Length | 427 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MACARPLISV11YSEKGESSGK21NVTLPAVFKA31PIRPDIVNFV41HTNLRKNNRQ
51-10051PYAVSELAGH61QTSAESWGTG71RAVARIPRVR81GGGTHRSGQG91AFGNMCRGGR
101-150101MFAPTKTWRR111WHRRVNTTQK121RYAICSALAA131SALPALVMSK141GHRIEEVPEL
151-200151PLVVEDKVEG161YKKTKEAVLL171LKKLKAWNDI181KKVYASQRMR191AGKGKMRNRR
201-250201RIQRRGPCII211YNEDNGIIKA221FRNIPGITLL231NVSKLNILKL241APGGHVGRFC
251-300251IWTESAFRKL261DELYGTWRKA271ASLKSNYNLP281MHKMINTDLS291RILKSPEIQR
301-350301ALRAPRKKIH311RRVLKKNPLK321NLRIMLKLNP331YAKTMRRNTI341LRQARNHKLR
351-400351VDKAAAAAAA361LQAKSDEKAA371VAGKKPVVGK381KGKKAAVGVK391KQKKPLVGKK
401-427401AAATKKPAPE411KKPAEKKPTT421EEKKPAA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | SWISSPALM DBPTM CYSMODDB | Large ribosomal subunit protein uL4 domain superfamily |
SW480 cell line
(26865113)
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.97
Deep-Palm: 0.04
|
| 96 | - |
SW480 cell line
(26865113)
HeLa
(37611173)
|
LNCaP
(31251020)
|
GPS-Palm: 0.87
Deep-Palm: 0.79
|
|
| 125 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.98
|
|
| 208 | - |
SW480 cell line
(26865113)
|
Unknown
(32651440)
|
GPS-Palm: 0.87
Deep-Palm: 0.45
|
|
| 250 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
LNCaP
Specificity: 0.364
4/4 (100.0%)
2
HAP1 cell
Specificity: 0.182
2/2 (100.0%)
1
U937 cell
Specificity: 0.091
1/1 (100.0%)
1
293T cell
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
Cerebral Cortex (Mass)
Specificity: 0.182
2/4 (50.0%)
1
LNCaP cells (Mass)
Specificity: 0.091
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 97 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 143 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 200 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 268 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 336 | R → C | 0.002033 | SNP | Missense Mutation | THCA |
| 342 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |