Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P36578 RPL4; RPL1 Large ribosomal subunit protein uL4 … Homo sapiens (Human) 427 aa

Protein Details: P36578 (RPL4)

Protein Information
Accession P36578
Protein Names Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4)
Gene Symbol RPL4; RPL1
Organism Homo sapiens (Human)
Length 427 aa
Isoforms No isoforms
Related PMIDs 19801377 29575903 29733200 31251020 31382980 32944167 36430497 37611173
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.644
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
38
LNCaP cells
Specificity: 0.644
38/46 (82.6%)
10
HAP1 cells
Specificity: 0.169
10/10 (100.0%)
4
293T cells
Specificity: 0.068
4/10 (40.0%)
3
PC3 cells
Specificity: 0.051
3/4 (75.0%)
3
Cerebral cortex
Specificity: 0.051
3/4 (75.0%)
1
U937 cells
Specificity: 0.017
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MACARPLISV11YSEKGESSGK21NVTLPAVFKA31PIRPDIVNFV41HTNLRKNNRQ
51-10051PYAVSELAGH61QTSAESWGTG71RAVARIPRVR81GGGTHRSGQG91AFGNMCRGGR
101-150101MFAPTKTWRR111WHRRVNTTQK121RYAICSALAA131SALPALVMSK141GHRIEEVPEL
151-200151PLVVEDKVEG161YKKTKEAVLL171LKKLKAWNDI181KKVYASQRMR191AGKGKMRNRR
201-250201RIQRRGPCII211YNEDNGIIKA221FRNIPGITLL231NVSKLNILKL241APGGHVGRFC
251-300251IWTESAFRKL261DELYGTWRKA271ASLKSNYNLP281MHKMINTDLS291RILKSPEIQR
301-350301ALRAPRKKIH311RRVLKKNPLK321NLRIMLKLNP331YAKTMRRNTI341LRQARNHKLR
351-400351VDKAAAAAAA361LQAKSDEKAA371VAGKKPVVGK381KGKKAAVGVK391KQKKPLVGKK
401-427401AAATKKPAPE411KKPAEKKPTT421EEKKPAA
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
3 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) - 29575903
96 Experimental Prediction (Medium) - 37611173, 19801377
125 Prediction (Medium) - -
208 Prediction (Medium) - -
250 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) - 29575903
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
97 R → C 0.002506 SNP Missense Mutation COAD
143 R → C 0.002141 SNP Missense Mutation SKCM
200 R → C 0.001887 SNP Missense Mutation UCEC
268 R → C 0.001887 SNP Missense Mutation UCEC
336 R → C 0.002033 SNP Missense Mutation THCA
342 R → C 0.001764 SNP Missense Mutation LUAD