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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P36894 BMPR1A Bone morphogenetic protein receptor type-1A … Homo sapiens (Human) 532 aa

Protein Details: P36894 (BMPR1A)

Protein Information
AccessionP36894
Protein NamesBone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
Gene SymbolBMPR1A
OrganismHomo sapiens (Human)
Length532 aa
IsoformsNo isoforms
Related PMIDs 31251020
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MPQLYIYIRL11LGAYLFIISR21VQGQNLDSML31HGTGMKSDSD41QKKSENGVTL
51-10051APEDTLPFLK61CYCSGHCPDD71AINNTCITNG81HCFAIIEEDD91QGETTLASGC
101-150101MKYEGSDFQC111KDSPKAQLRR121TIECCRTNLC131NQYLQPTLPP141VVIGPFFDGS
151-200151IRWLVLLISM161AVCIIAMIIF171SSCFCYKHYC181KSISSRRRYN191RDLEQDEAFI
201-250201PVGESLKDLI211DQSQSSGSGS221GLPLLVQRTI231AKQIQMVRQV241GKGRYGEVWM
251-300251GKWRGEKVAV261KVFFTTEEAS271WFRETEIYQT281VLMRHENILG291FIAADIKGTG
301-350301SWTQLYLITD311YHENGSLYDF321LKCATLDTRA331LLKLAYSAAC341GLCHLHTEIY
351-400351GTQGKPAIAH361RDLKSKNILI371KKNGSCCIAD381LGLAVKFNSD391TNEVDVPLNT
401-450401RVGTKRYMAP411EVLDESLNKN421HFQPYIMADI431YSFGLIIWEM441ARRCITGGIV
451-500451EEYQLPYYNM461VPSDPSYEDM471REVVCVKRLR481PIVSNRWNSD491ECLRAVLKLM
501-532501SECWAHNPAS511RLTALRIKKT521LAKMVESQDV531KI
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
61 - - -
Deep-Palm: 0.12
63 - - -
Deep-Palm: 0.06
67 - - -
Deep-Palm: 0.02
76 - - -
Deep-Palm: 0.01
82 - - -
Deep-Palm: 0.04
100 - - -
Deep-Palm: 0.54
110 - - -
Deep-Palm: 0.68
124 - - -
GPS-Palm: 0.73
Deep-Palm: 0.28
125 - - -
GPS-Palm: 0.89
Deep-Palm: 0.40
130 - - -
Deep-Palm: 0.45
163 - - -
Deep-Palm: 0.16
173 SWISSPALM - - -
GPS-Palm: 0.82
Deep-Palm: 0.15
175 SWISSPALM - - -
GPS-Palm: 0.78
Deep-Palm: 0.07
180 SWISSPALM - - -
GPS-Palm: 0.75
Deep-Palm: 0.20
323 - - -
Deep-Palm: 0.91
340 - - -
Deep-Palm: 0.73
343 - - -
Deep-Palm: 0.70
376 - - -
GPS-Palm: 0.79
Deep-Palm: 0.77
377 - - -
GPS-Palm: 0.91
Deep-Palm: 0.72
444 - - -
GPS-Palm: 0.86
Deep-Palm: 0.11
475 - - -
GPS-Palm: 0.78
Deep-Palm: 0.70
492 - - -
GPS-Palm: 0.75
Deep-Palm: 0.19
503 - - -
GPS-Palm: 0.85
Deep-Palm: 0.39
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
61 C → Y 0.002747 SNP Missense Mutation LIHC
76 C → Y 0.001887 SNP Missense Mutation UCEC
173 C → C 0.002506 SNP Silent COAD
179 Y → C 0.001887 SNP Missense Mutation UCEC
191 R → C 0.002141 SNP Missense Mutation SKCM
245 Y → C 0.002506 SNP Missense Mutation COAD
278 Y → C 0.002020 SNP Missense Mutation PRAD
376 C → R 0.002288 SNP Missense Mutation STAD
471 R → C 0.001887 SNP Missense Mutation UCEC
82* C → ? 0.002545 SNP Nonsense Mutation GBM