Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P38060 | Hmgcl | Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA … | Mus musculus (Mouse) | 325 aa |
Protein Details: P38060 (Hmgcl)
Protein Information
| Accession | P38060 |
|---|---|
| Protein Names | Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase) |
| Gene Symbol | Hmgcl |
| Organism | Mus musculus (Mouse) |
| Length | 325 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 34884899 35477839 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASVRKAFPR11RLVGLTSLRA21VSTSSMGTLP31KQVKIVEVGP41RDGLQNEKSI
51-10051VPTPVKIRLI61DMLSEAGLPV71IEATSFVSPK81WVPQMADHSD91VLKGIQKFPG
101-150101INYPVLTPNM111KGFEEAVAAG121AKEVSVFGAV131SELFTRKNAN141CSIEESFQRF
151-200151AGVMQAAQAA161SISVRGYVSC171ALGCPYEGKV181SPAKVAEVAK191KLYSMGCYEI
201-250201SLGDTIGVGT211PGLMKDMLTA221VMHEVPVTAL231AVHCHDTYGQ241ALANTLVALQ
251-300251MGVSVVDSSV261AGLGGCPYAK271GASGNLATED281LVYMLNGLGI291HTGVNLQKLL
301-325301EAGDFICQAL311NRKTSSKVAQ321ATCKL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 141 | SWISSPALM DBPTM CYSMODDB | HMGL-like |
Liver
(28526873)
liver
(26165157)
|
Liver
(37925639)
Brain
(35358180)
|
GPS-Palm: 0.82
Deep-Palm: 0.91
|
| 170 | SWISSPALM DBPTM CYSMODDB | - |
Liver
(28526873)
|
Brain
(35358180)
|
GPS-Palm: 0.90
Deep-Palm: 0.90
|
| 174 | SWISSPALM DBPTM CYSMODDB | - |
Liver
(28526873)
|
Brain
(35358180)
|
GPS-Palm: 0.86
Deep-Palm: 0.94
|
| 197 | - | - | - |
Deep-Palm: 0.94
|
|
| 234 | - | - | - |
Deep-Palm: 0.94
|
|
| 266 | - | - | - |
Deep-Palm: 0.97
|
|
| 307 | SWISSPALM DBPTM CYSMODDB | - |
Liver
(28526873)
liver
(26165157)
|
Liver
(37925639)
Brain
(35358180)
|
GPS-Palm: 0.95
Deep-Palm: 0.98
|
| 323 | - |
brain
(39008777)
| - |
GPS-Palm: 0.97
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
6
Liver
Specificity: 0.200
6/6 (100.0%)
2
Testis
Specificity: 0.067
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.773
17
Brain tissue (Mass)
Specificity: 0.567
17/56 (30.4%)
5
Liver tissue (Mass)
Specificity: 0.167
5/8 (62.5%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.