Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P38646 | HSPA9 | Stress-70 protein, mitochondrial (EC 3.6.4.10) … | Homo sapiens (Human) | 679 aa |
Protein Details: P38646 (HSPA9)
Protein Information
| Accession | P38646 |
|---|---|
| Protein Names | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) |
| Gene Symbol | HSPA9 |
| Organism | Homo sapiens (Human) |
| Length | 679 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29733200 31251020 31382980 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MISASRAAAA11RLVGAAASRG21PTAARHQDSW31NGLSHEAFRL41VSRRDYASEA
51-10051IKGAVVGIDL61GTTNSCVAVM71EGKQAKVLEN81AEGARTTPSV91VAFTADGERL
101-150101VGMPAKRQAV111TNPNNTFYAT121KRLIGRRYDD131PEVQKDIKNV141PFKIVRASNG
151-200151DAWVEAHGKL161YSPSQIGAFV171LMKMKETAEN181YLGHTAKNAV191ITVPAYFNDS
201-250201QRQATKDAGQ211ISGLNVLRVI221NEPTAAALAY231GLDKSEDKVI241AVYDLGGGTF
251-300251DISILEIQKG261VFEVKSTNGD271TFLGGEDFDQ281ALLRHIVKEF291KRETGVDLTK
301-350301DNMALQRVRE311AAEKAKCELS321SSVQTDINLP331YLTMDSSGPK341HLNMKLTRAQ
351-400351FEGIVTDLIR361RTIAPCQKAM371QDAEVSKSDI381GEVILVGGMT391RMPKVQQTVQ
401-450401DLFGRAPSKA411VNPDEAVAIG421AAIQGGVLAG431DVTDVLLLDV441TPLSLGIETL
451-500451GGVFTKLINR461NTTIPTKKSQ471VFSTAADGQT481QVEIKVCQGE491REMAGDNKLL
501-550501GQFTLIGIPP511APRGVPQIEV521TFDIDANGIV531HVSAKDKGTG541REQQIVIQSS
551-600551GGLSKDDIEN561MVKNAEKYAE571EDRRKKERVE581AVNMAEGIIH591DTETKMEEFK
601-650601DQLPADECNK611LKEEISKMRE621LLARKDSETG631ENIRQAASSL641QQASLKLFEM
651-679651AYKKMASERE661GSGSSGTGEQ671KEDQKEEKQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 66 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.82
Deep-Palm: 0.97
|
|
| 317 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.82
Deep-Palm: 0.96
|
|
| 366 | SWISSPALM DBPTM CYSMODDB | Hsp70 protein | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.96
|
| 487 | - | - | - |
Deep-Palm: 0.79
|
|
| 608 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
3
LNCaP
Specificity: 0.250
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.167
2/2 (100.0%)
1
U937 cell
Specificity: 0.083
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.083
1/1 (100.0%)
1
293T cell
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 148 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 599 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |