Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P39023 | RPL3 | Large ribosomal subunit protein uL3 … | Homo sapiens (Human) | 403 aa |
Protein Details: P39023 (RPL3)
Protein Information
| Accession | P39023 |
|---|---|
| Protein Names | Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) |
| Gene Symbol | RPL3 |
| Organism | Homo sapiens (Human) |
| Length | 403 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 29733200 31251020 31382980 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSHRKFSAPR11HGSLGFLPRK21RSSRHRGKVK31SFPKDDPSKP41VHLTAFLGYK
51-10051AGMTHIVREV61DRPGSKVNKK71EVVEAVTIVE81TPPMVVVGIV91GYVETPRGLR
101-150101TFKTVFAEHI111SDECKRRFYK121NWHKSKKKAF131TKYCKKWQDE141DGKKQLEKDF
151-200151SSMKKYCQVI161RVIAHTQMRL171LPLRQKKAHL181MEIQVNGGTV191AEKLDWARER
201-250201LEQQVPVNQV211FGQDEMIDVI221GVTKGKGYKG231VTSRWHTKKL241PRKTHRGLRK
251-300251VACIGAWHPA261RVAFSVARAG271QKGYHHRTEI281NKKIYKIGQG291YLIKDGKLIK
301-350301NNASTDYDLS311DKSINPLGGF321VHYGEVTNDF331VMLKGCVVGT341KKRVLTLRKS
351-400351LLVQTKRRAL361EKIDLKFIDT371TSKFGHGRFQ381TMEEKKAFMG391PLKKDRIAKE
401-403401EGA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 114 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.44
|
|
| 134 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.28
|
|
| 157 | - |
SW480 cell line
(26865113)
| - |
GPS-Palm: 0.78
Deep-Palm: 0.85
|
|
| 253 | SWISSPALM DBPTM CYSMODDB | Ribosomal protein L3 |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.97
|
| 336 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
3
LNCaP
Specificity: 0.273
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.182
2/2 (100.0%)
1
U937 cell
Specificity: 0.091
1/1 (100.0%)
1
HeLa cell
Specificity: 0.091
1/1 (100.0%)
1
293T cell
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.273
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 249 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 291 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |