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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) … Homo sapiens (Human) 397 aa

Protein Details: P42765 (ACAA2)

Protein Information
Accession P42765
Protein Names 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)
Gene Symbol ACAA2
Organism Homo sapiens (Human)
Length 397 aa
Isoforms No isoforms
Related PMIDs 29575903 29733200 32944167 33636221 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
6
HAP1 cells
Specificity: 0.429
6/10 (60.0%)
4
Cerebral cortex
Specificity: 0.286
4/4 (100.0%)
2
PC3 cells
Specificity: 0.143
2/4 (50.0%)
1
HeLa cells
Specificity: 0.071
1/1 (100.0%)
1
Liver membrane
Specificity: 0.071
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MALLRGVFVV11AAKRTPFGAY21GGLLKDFTAT31DLSEFAAKAA41LSAGKVSPET
51-10051VDSVIMGNVL61QSSSDAIYLA71RHVGLRVGIP81KETPALTINR91LCGSGFQSIV
101-150101NGCQEICVKE111AEVVLCGGTE121SMSQAPYCVR131NVRFGTKLGS141DIKLEDSLWV
151-200151SLTDQHVQLP161MAMTAENLAV171KHKISREECD181KYALQSQQRW191KAANDAGYFN
201-250201DEMAPIEVKT211KKGKQTMQVD221EHARPQTTLE231QLQKLPPVFK241KDGTVTAGNA
251-300251SGVADGAGAV261IIASEDAVKK271HNFTPLARIV281GYFVSGCDPS291IMGIGPVPAI
301-350301SGALKKAGLS311LKDMDLVEVN321EAFAPQYLAV331ERSLDLDISK341TNVNGGAIAL
351-397351GHPLGGSGSR361ITAHLVHELR371RRGGKYAVGS381ACIGGGQGIA391VIIQSTA
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
92 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) Thiolase N-terminal domain 29575903
128 Prediction (High) - -
179 Experimental Thiolase N-terminal domain 29575903
287 Prediction (Low) - -
382 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
76 R → C 0.002288 SNP Missense Mutation STAD
371 R → C 0.001969 SNP Missense Mutation LGG