Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P42765 | ACAA2 | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) … | Homo sapiens (Human) | 397 aa |
Protein Details: P42765 (ACAA2)
Protein Information
| Accession | P42765 |
|---|---|
| Protein Names | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1) |
| Gene Symbol | ACAA2 |
| Organism | Homo sapiens (Human) |
| Length | 397 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 29733200 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MALLRGVFVV11AAKRTPFGAY21GGLLKDFTAT31DLSEFAAKAA41LSAGKVSPET
51-10051VDSVIMGNVL61QSSSDAIYLA71RHVGLRVGIP81KETPALTINR91LCGSGFQSIV
101-150101NGCQEICVKE111AEVVLCGGTE121SMSQAPYCVR131NVRFGTKLGS141DIKLEDSLWV
151-200151SLTDQHVQLP161MAMTAENLAV171KHKISREECD181KYALQSQQRW191KAANDAGYFN
201-250201DEMAPIEVKT211KKGKQTMQVD221EHARPQTTLE231QLQKLPPVFK241KDGTVTAGNA
251-300251SGVADGAGAV261IIASEDAVKK271HNFTPLARIV281GYFVSGCDPS291IMGIGPVPAI
301-350301SGALKKAGLS311LKDMDLVEVN321EAFAPQYLAV331ERSLDLDISK341TNVNGGAIAL
351-397351GHPLGGSGSR361ITAHLVHELR371RRGGKYAVGS381ACIGGGQGIA391VIIQSTA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 92 | SWISSPALM DBPTM CYSMODDB | Thiolase N-terminal domain | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.88
Deep-Palm: 0.96
|
| 103 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.88
|
|
| 107 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.85
|
|
| 116 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.79
|
|
| 128 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.96
|
|
| 179 | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
Deep-Palm: 0.71
|
|
| 287 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.86
|
|
| 382 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
2
HeLa cell
Specificity: 0.167
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.083
1/1 (100.0%)
1
heart
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 76 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 371 | R → C | 0.001969 | SNP | Missense Mutation | LGG |