Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P42858 | HTT; HD; IT15 | Huntingtin (Huntington disease protein) (HD … | Homo sapiens (Human) | 3142 aa |
Protein Details: P42858 (HTT)
Protein Information
| Accession | P42858 |
|---|---|
| Protein Names | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] |
| Gene Symbol | HTT; HD; IT15 |
| Organism | Homo sapiens (Human) |
| Length | 3142 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 36430497 37611173 |
| Database Sources | dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
6
LNCaP cells
Specificity: 0.600
6/46 (13.0%)
3
Cerebral cortex
Specificity: 0.300
3/4 (75.0%)
1
U937 cells
Specificity: 0.100
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MATLEKLMKA11FESLKSFQQQ21QQQQQQQQQQ31QQQQQQQQPP41PPPPPPPPPQ
51-10051LPQPPPQAQP61LLPQPQPPPP71PPPPPPGPAV81AEEPLHRPKK91ELSATKKDRV
101-150101NHCLTICENI111VAQSVRNSPE121FQKLLGIAME131LFLLCSDDAE141SDVRMVADEC
151-200151LNKVIKALMD161SNLPRLQLEL171YKEIKKNGAP181RSLRAALWRF191AELAHLVRPQ
201-250201KCRPYLVNLL211PCLTRTSKRP221EESVQETLAA231AVPKIMASFG241NFANDNEIKV
251-300251LLKAFIANLK261SSSPTIRRTA271AGSAVSICQH281SRRTQYFYSW291LLNVLLGLLV
301-350301PVEDEHSTLL311ILGVLLTLRY321LVPLLQQQVK331DTSLKGSFGV341TRKEMEVSPS
351-400351AEQLVQVYEL361TLHHTQHQDH371NVVTGALELL381QQLFRTPPPE391LLQTLTAVGG
401-450401IGQLTAAKEE411SGGRSRSGSI421VELIAGGGSS431CSPVLSRKQK441GKVLLGEEEA
451-500451LEDDSESRSD461VSSSALTASV471KDEISGELAA481SSGVSTPGSA491GHDIITEQPR
501-550501SQHTLQADSV511DLASCDLTSS521ATDGDEEDIL531SHSSSQVSAV541PSDPAMDLND
551-600551GTQASSPISD561SSQTTTEGPD571SAVTPSDSSE581IVLDGTDNQY591LGLQIGQPQD
601-650601EDEEATGILP611DEASEAFRNS621SMALQQAHLL631KNMSHCRQPS641DSSVDKFVLR
651-700651DEATEPGDQE661NKPCRIKGDI671GQSTDDDSAP681LVHCVRLLSA691SFLLTGGKNV
701-750701LVPDRDVRVS711VKALALSCVG721AAVALHPESF731FSKLYKVPLD741TTEYPEEQYV
751-800751SDILNYIDHG761DPQVRGATAI771LCGTLICSIL781SRSRFHVGDW791MGTIRTLTGN
801-850801TFSLADCIPL811LRKTLKDESS821VTCKLACTAV831RNCVMSLCSS841SYSELGLQLI
851-900851IDVLTLRNSS861YWLVRTELLE871TLAEIDFRLV881SFLEAKAENL891HRGAHHYTGL
901-950901LKLQERVLNN911VVIHLLGDED921PRVRHVAAAS931LIRLVPKLFY941KCDQGQADPV
951-1000951VAVARDQSSV961YLKLLMHETQ971PPSHFSVSTI981TRIYRGYNLL991PSITDVTMEN
1001-10501001NLSRVIAAVS1011HELITSTTRA1021LTFGCCEALC1031LLSTAFPVCI1041WSLGWHCGVP
1051-11001051PLSASDESRK1061SCTVGMATMI1071LTLLSSAWFP1081LDLSAHQDAL1091ILAGNLLAAS
1101-11501101APKSLRSSWA1111SEEEANPAAT1121KQEEVWPALG1131DRALVPMVEQ1141LFSHLLKVIN
1151-12001151ICAHVLDDVA1161PGPAIKAALP1171SLTNPPSLSP1181IRRKGKEKEP1191GEQASVPLSP
1201-12501201KKGSEASAAS1211RQSDTSGPVT1221TSKSSSLGSF1231YHLPSYLKLH1241DVLKATHANY
1251-13001251KVTLDLQNST1261EKFGGFLRSA1271LDVLSQILEL1281ATLQDIGKCV1291EEILGYLKSC
1301-13501301FSREPMMATV1311CVQQLLKTLF1321GTNLASQFDG1331LSSNPSKSQG1341RAQRLGSSSV
1351-14001351RPGLYHYCFM1361APYTHFTQAL1371ADASLRNMVQ1381AEQENDTSGW1391FDVLQKVSTQ
1401-14501401LKTNLTSVTK1411NRADKNAIHN1421HIRLFEPLVI1431KALKQYTTTT1441CVQLQKQVLD
1451-15001451LLAQLVQLRV1461NYCLLDSDQV1471FIGFVLKQFE1481YIEVGQFRES1491EAIIPNIFFF
1501-15501501LVLLSYERYH1511SKQIIGIPKI1521IQLCDGIMAS1531GRKAVTHAIP1541ALQPIVHDLF
1551-16001551VLRGTNKADA1561GKELETQKEV1571VVSMLLRLIQ1581YHQVLEMFIL1591VLQQCHKENE
1601-16501601DKWKRLSRQI1611ADIILPMLAK1621QQMHIDSHEA1631LGVLNTLFEI1641LAPSSLRPVD
1651-17001651MLLRSMFVTP1661NTMASVSTVQ1671LWISGILAIL1681RVLISQSTED1691IVLSRIQELS
1701-17501701FSPYLISCTV1711INRLRDGDST1721STLEEHSEGK1731QIKNLPEETF1741SRFLLQLVGI
1751-18001751LLEDIVTKQL1761KVEMSEQQHT1771FYCQELGTLL1781MCLIHIFKSG1791MFRRITAAAT
1801-18501801RLFRSDGCGG1811SFYTLDSLNL1821RARSMITTHP1831ALVLLWCQIL1841LLVNHTDYRW
1851-19001851WAEVQQTPKR1861HSLSSTKLLS1871PQMSGEEEDS1881DLAAKLGMCN1891REIVRRGALI
1901-19501901LFCDYVCQNL1911HDSEHLTWLI1921VNHIQDLISL1931SHEPPVQDFI1941SAVHRNSAAS
1951-20001951GLFIQAIQSR1961CENLSTPTML1971KKTLQCLEGI1981HLSQSGAVLT1991LYVDRLLCTP
2001-20502001FRVLARMVDI2011LACRRVEMLL2021AANLQSSMAQ2031LPMEELNRIQ2041EYLQSSGLAQ
2051-21002051RHQRLYSLLD2061RFRLSTMQDS2071LSPSPPVSSH2081PLDGDGHVSL2091ETVSPDKDWY
2101-21502101VHLVKSQCWT2111RSDSALLEGA2121ELVNRIPAED2131MNAFMMNSEF2141NLSLLAPCLS
2151-22002151LGMSEISGGQ2161KSALFEAARE2171VTLARVSGTV2181QQLPAVHHVF2191QPELPAEPAA
2201-22502201YWSKLNDLFG2211DAALYQSLPT2221LARALAQYLV2231VVSKLPSHLH2241LPPEKEKDIV
2251-23002251KFVVATLEAL2261SWHLIHEQIP2271LSLDLQAGLD2281CCCLALQLPG2291LWSVVSSTEF
2301-23502301VTHACSLIYC2311VHFILEAVAV2321QPGEQLLSPE2331RRTNTPKAIS2341EEEEEVDPNT
2351-24002351QNPKYITAAC2361EMVAEMVESL2371QSVLALGHKR2381NSGVPAFLTP2391LLRNIIISLA
2401-24502401RLPLVNSYTR2411VPPLVWKLGW2421SPKPGGDFGT2431AFPEIPVEFL2441QEKEVFKEFI
2451-25002451YRINTLGWTS2461RTQFEETWAT2471LLGVLVTQPL2481VMEQEESPPE2491EDTERTQINV
2501-25502501LAVQAITSLV2511LSAMTVPVAG2521NPAVSCLEQQ2531PRNKPLKALD2541TRFGRKLSII
2551-26002551RGIVEQEIQA2561MVSKRENIAT2571HHLYQAWDPV2581PSLSPATTGA2591LISHEKLLLQ
2601-26502601INPERELGSM2611SYKLGQVSIH2621SVWLGNSITP2631LREEEWDEEE2641EEEADAPAPS
2651-27002651SPPTSPVNSR2661KHRAGVDIHS2671CSQFLLELYS2681RWILPSSSAR2691RTPAILISEV
2701-27502701VRSLLVVSDL2711FTERNQFELM2721YVTLTELRRV2731HPSEDEILAQ2741YLVPATCKAA
2751-28002751AVLGMDKAVA2761EPVSRLLEST2771LRSSHLPSRV2781GALHGVLYVL2791ECDLLDDTAK
2801-28502801QLIPVISDYL2811LSNLKGIAHC2821VNIHSQQHVL2831VMCATAFYLI2841ENYPLDVGPE
2851-29002851FSASIIQMCG2861VMLSGSEEST2871PSIIYHCALR2881GLERLLLSEQ2891LSRLDAESLV
2901-29502901KLSVDRVNVH2911SPHRAMAALG2921LMLTCMYTGK2931EKVSPGRTSD2941PNPAAPDSES
2951-30002951VIVAMERVSV2961LFDRIRKGFP2971CEARVVARIL2981PQFLDDFFPP2991QDIMNKVIGE
3001-30503001FLSNQQPYPQ3011FMATVVYKVF3021QTLHSTGQSS3031MVRDWVMLSL3041SNFTQRAPVA
3051-31003051MATWSLSCFF3061VSASTSPWVA3071AILPHVISRM3081GKLEQVDVNL3091FCLVATDFYR
3101-31423101HQIEEELDRR3111AFQSVLEVVA3121APGSPYHRLL3131TCLRNVHKVT3141TC
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 103 | Prediction (Medium) | - | - |
| 107 | Prediction (Low) | - | - |
| 135 | Prediction (Low) | - | - |
| 150 | Prediction (Medium) | - | - |
| 212 | DBPTM SWISSPALM Prediction (High) | Huntingtin N-terminal HEAT 1 | - |
| 278 | Prediction (Medium) | - | - |
| 431 | Prediction (High) | - | - |
| 718 | Prediction (Medium) | - | - |
| 772 | Prediction (Medium) | - | - |
| 777 | Prediction (High) | - | - |
| 807 | Prediction (High) | - | - |
| 823 | Prediction (Medium) | - | - |
| 827 | Prediction (Low) | - | - |
| 833 | Prediction (Medium) | - | - |
| 838 | Prediction (Low) | - | - |
| 942 | Prediction (Low) | - | - |
| 1025 | Prediction (Medium) | - | - |
| 1026 | Prediction (High) | - | - |
| 1152 | Prediction (Low) | - | - |
| 1300 | Prediction (Low) | - | - |
| 1311 | Prediction (Low) | - | - |
| 1441 | Prediction (Medium) | - | - |
| 1524 | Prediction (High) | - | - |
| 1595 | Experimental Prediction (Medium) | Huntingtin N-terminal HEAT | 37611173 |
| 1708 | Prediction (Medium) | - | - |
| 1808 | Prediction (Medium) | - | - |
| 1889 | Prediction (High) | - | - |
| 1903 | Prediction (High) | - | - |
| 1976 | Prediction (Low) | - | - |
| 1998 | Prediction (High) | - | - |
| 2013 | Prediction (High) | - | - |
| 2281 | Prediction (Medium) | - | - |
| 2282 | Prediction (Medium) | - | - |
| 2283 | Prediction (Medium) | - | - |
| 2526 | Prediction (Medium) | - | - |
| 2671 | Prediction (Low) | - | - |
| 2747 | Prediction (Medium) | - | - |
| 2792 | Prediction (Low) | - | - |
| 2877 | Prediction (Low) | - | - |
| 2925 | Prediction (Medium) | - | - |
| 2971 | Prediction (Medium) | - | - |
| 3092 | Prediction (Low) | - | - |
| 3142 | Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 135 | C → C | 0.001887 | SNP | Silent | UCEC |
| 150 | C → Y | 0.001969 | SNP | Missense Mutation | HNSC |
| 150 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 161 | S → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 184 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 515 | C → C | 0.002545 | SNP | Silent | GBM |
| 686 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 819 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 823 | C → C | 0.002288 | SNP | Silent | STAD |
| 1171 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1268 | R → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 1299 | S → C | 0.002545 | SNP | Missense Mutation | GBM |
| 1336 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1344 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1412 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1436 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1595 | C → S | 0.002294 | SNP | Missense Mutation | OV |
| 1647 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1704 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1773 | C → delins* | 0.001887 | INS | Nonsense Mutation | UCEC |
| 1862 | S → C | 0.002294 | SNP | Missense Mutation | OV |
| 1960 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1976 | C → F | 0.002976 | SNP | Missense Mutation | KIRC |
| 2006 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 2063 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 2063 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 2319 | A → Cfs*10 | 0.002288 | INS | Frame Shift Ins | STAD |
| 2461 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 2487 | S → C | 0.002288 | SNP | Missense Mutation | STAD |
| 2543 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 2888 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 3126 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |