Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P42858 | HTT | Huntingtin (Huntington disease protein) (HD … | Homo sapiens (Human) | 3142 aa |
Protein Details: P42858 (HTT)
Protein Information
| Accession | P42858 |
|---|---|
| Protein Names | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] |
| Gene Symbol | HTT |
| Organism | Homo sapiens (Human) |
| Length | 3142 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31382980 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MATLEKLMKA11FESLKSFQQQ21QQQQQQQQQQ31QQQQQQQQPP41PPPPPPPPPQ
51-10051LPQPPPQAQP61LLPQPQPPPP71PPPPPPGPAV81AEEPLHRPKK91ELSATKKDRV
101-150101NHCLTICENI111VAQSVRNSPE121FQKLLGIAME131LFLLCSDDAE141SDVRMVADEC
151-200151LNKVIKALMD161SNLPRLQLEL171YKEIKKNGAP181RSLRAALWRF191AELAHLVRPQ
201-250201KCRPYLVNLL211PCLTRTSKRP221EESVQETLAA231AVPKIMASFG241NFANDNEIKV
251-300251LLKAFIANLK261SSSPTIRRTA271AGSAVSICQH281SRRTQYFYSW291LLNVLLGLLV
301-350301PVEDEHSTLL311ILGVLLTLRY321LVPLLQQQVK331DTSLKGSFGV341TRKEMEVSPS
351-400351AEQLVQVYEL361TLHHTQHQDH371NVVTGALELL381QQLFRTPPPE391LLQTLTAVGG
401-450401IGQLTAAKEE411SGGRSRSGSI421VELIAGGGSS431CSPVLSRKQK441GKVLLGEEEA
451-500451LEDDSESRSD461VSSSALTASV471KDEISGELAA481SSGVSTPGSA491GHDIITEQPR
501-550501SQHTLQADSV511DLASCDLTSS521ATDGDEEDIL531SHSSSQVSAV541PSDPAMDLND
551-600551GTQASSPISD561SSQTTTEGPD571SAVTPSDSSE581IVLDGTDNQY591LGLQIGQPQD
601-650601EDEEATGILP611DEASEAFRNS621SMALQQAHLL631KNMSHCRQPS641DSSVDKFVLR
651-700651DEATEPGDQE661NKPCRIKGDI671GQSTDDDSAP681LVHCVRLLSA691SFLLTGGKNV
701-750701LVPDRDVRVS711VKALALSCVG721AAVALHPESF731FSKLYKVPLD741TTEYPEEQYV
751-800751SDILNYIDHG761DPQVRGATAI771LCGTLICSIL781SRSRFHVGDW791MGTIRTLTGN
801-850801TFSLADCIPL811LRKTLKDESS821VTCKLACTAV831RNCVMSLCSS841SYSELGLQLI
851-900851IDVLTLRNSS861YWLVRTELLE871TLAEIDFRLV881SFLEAKAENL891HRGAHHYTGL
901-950901LKLQERVLNN911VVIHLLGDED921PRVRHVAAAS931LIRLVPKLFY941KCDQGQADPV
951-1000951VAVARDQSSV961YLKLLMHETQ971PPSHFSVSTI981TRIYRGYNLL991PSITDVTMEN
1001-10501001NLSRVIAAVS1011HELITSTTRA1021LTFGCCEALC1031LLSTAFPVCI1041WSLGWHCGVP
1051-11001051PLSASDESRK1061SCTVGMATMI1071LTLLSSAWFP1081LDLSAHQDAL1091ILAGNLLAAS
1101-11501101APKSLRSSWA1111SEEEANPAAT1121KQEEVWPALG1131DRALVPMVEQ1141LFSHLLKVIN
1151-12001151ICAHVLDDVA1161PGPAIKAALP1171SLTNPPSLSP1181IRRKGKEKEP1191GEQASVPLSP
1201-12501201KKGSEASAAS1211RQSDTSGPVT1221TSKSSSLGSF1231YHLPSYLKLH1241DVLKATHANY
1251-13001251KVTLDLQNST1261EKFGGFLRSA1271LDVLSQILEL1281ATLQDIGKCV1291EEILGYLKSC
1301-13501301FSREPMMATV1311CVQQLLKTLF1321GTNLASQFDG1331LSSNPSKSQG1341RAQRLGSSSV
1351-14001351RPGLYHYCFM1361APYTHFTQAL1371ADASLRNMVQ1381AEQENDTSGW1391FDVLQKVSTQ
1401-14501401LKTNLTSVTK1411NRADKNAIHN1421HIRLFEPLVI1431KALKQYTTTT1441CVQLQKQVLD
1451-15001451LLAQLVQLRV1461NYCLLDSDQV1471FIGFVLKQFE1481YIEVGQFRES1491EAIIPNIFFF
1501-15501501LVLLSYERYH1511SKQIIGIPKI1521IQLCDGIMAS1531GRKAVTHAIP1541ALQPIVHDLF
1551-16001551VLRGTNKADA1561GKELETQKEV1571VVSMLLRLIQ1581YHQVLEMFIL1591VLQQCHKENE
1601-16501601DKWKRLSRQI1611ADIILPMLAK1621QQMHIDSHEA1631LGVLNTLFEI1641LAPSSLRPVD
1651-17001651MLLRSMFVTP1661NTMASVSTVQ1671LWISGILAIL1681RVLISQSTED1691IVLSRIQELS
1701-17501701FSPYLISCTV1711INRLRDGDST1721STLEEHSEGK1731QIKNLPEETF1741SRFLLQLVGI
1751-18001751LLEDIVTKQL1761KVEMSEQQHT1771FYCQELGTLL1781MCLIHIFKSG1791MFRRITAAAT
1801-18501801RLFRSDGCGG1811SFYTLDSLNL1821RARSMITTHP1831ALVLLWCQIL1841LLVNHTDYRW
1851-19001851WAEVQQTPKR1861HSLSSTKLLS1871PQMSGEEEDS1881DLAAKLGMCN1891REIVRRGALI
1901-19501901LFCDYVCQNL1911HDSEHLTWLI1921VNHIQDLISL1931SHEPPVQDFI1941SAVHRNSAAS
1951-20001951GLFIQAIQSR1961CENLSTPTML1971KKTLQCLEGI1981HLSQSGAVLT1991LYVDRLLCTP
2001-20502001FRVLARMVDI2011LACRRVEMLL2021AANLQSSMAQ2031LPMEELNRIQ2041EYLQSSGLAQ
2051-21002051RHQRLYSLLD2061RFRLSTMQDS2071LSPSPPVSSH2081PLDGDGHVSL2091ETVSPDKDWY
2101-21502101VHLVKSQCWT2111RSDSALLEGA2121ELVNRIPAED2131MNAFMMNSEF2141NLSLLAPCLS
2151-22002151LGMSEISGGQ2161KSALFEAARE2171VTLARVSGTV2181QQLPAVHHVF2191QPELPAEPAA
2201-22502201YWSKLNDLFG2211DAALYQSLPT2221LARALAQYLV2231VVSKLPSHLH2241LPPEKEKDIV
2251-23002251KFVVATLEAL2261SWHLIHEQIP2271LSLDLQAGLD2281CCCLALQLPG2291LWSVVSSTEF
2301-23502301VTHACSLIYC2311VHFILEAVAV2321QPGEQLLSPE2331RRTNTPKAIS2341EEEEEVDPNT
2351-24002351QNPKYITAAC2361EMVAEMVESL2371QSVLALGHKR2381NSGVPAFLTP2391LLRNIIISLA
2401-24502401RLPLVNSYTR2411VPPLVWKLGW2421SPKPGGDFGT2431AFPEIPVEFL2441QEKEVFKEFI
2451-25002451YRINTLGWTS2461RTQFEETWAT2471LLGVLVTQPL2481VMEQEESPPE2491EDTERTQINV
2501-25502501LAVQAITSLV2511LSAMTVPVAG2521NPAVSCLEQQ2531PRNKPLKALD2541TRFGRKLSII
2551-26002551RGIVEQEIQA2561MVSKRENIAT2571HHLYQAWDPV2581PSLSPATTGA2591LISHEKLLLQ
2601-26502601INPERELGSM2611SYKLGQVSIH2621SVWLGNSITP2631LREEEWDEEE2641EEEADAPAPS
2651-27002651SPPTSPVNSR2661KHRAGVDIHS2671CSQFLLELYS2681RWILPSSSAR2691RTPAILISEV
2701-27502701VRSLLVVSDL2711FTERNQFELM2721YVTLTELRRV2731HPSEDEILAQ2741YLVPATCKAA
2751-28002751AVLGMDKAVA2761EPVSRLLEST2771LRSSHLPSRV2781GALHGVLYVL2791ECDLLDDTAK
2801-28502801QLIPVISDYL2811LSNLKGIAHC2821VNIHSQQHVL2831VMCATAFYLI2841ENYPLDVGPE
2851-29002851FSASIIQMCG2861VMLSGSEEST2871PSIIYHCALR2881GLERLLLSEQ2891LSRLDAESLV
2901-29502901KLSVDRVNVH2911SPHRAMAALG2921LMLTCMYTGK2931EKVSPGRTSD2941PNPAAPDSES
2951-30002951VIVAMERVSV2961LFDRIRKGFP2971CEARVVARIL2981PQFLDDFFPP2991QDIMNKVIGE
3001-30503001FLSNQQPYPQ3011FMATVVYKVF3021QTLHSTGQSS3031MVRDWVMLSL3041SNFTQRAPVA
3051-31003051MATWSLSCFF3061VSASTSPWVA3071AILPHVISRM3081GKLEQVDVNL3091FCLVATDFYR
3101-31423101HQIEEELDRR3111AFQSVLEVVA3121APGSPYHRLL3131TCLRNVHKVT3141TC
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 103 | - | - |
Jurkat T
(32651440)
|
GPS-Palm: 0.79
Deep-Palm: 0.82
|
|
| 107 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.70
|
|
| 135 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.90
|
|
| 150 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.89
|
|
| 202 | - | - | - |
Deep-Palm: 0.94
|
|
| 212 | DBPTM SWISSPALM | Huntingtin N-terminal HEAT 1 | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.94
|
| 278 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.79
|
|
| 431 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.97
|
|
| 515 | - | - | - |
Deep-Palm: 0.90
|
|
| 636 | - | - | - |
Deep-Palm: 0.53
|
|
| 664 | - | - | - |
Deep-Palm: 0.55
|
|
| 684 | - | - | - |
Deep-Palm: 0.90
|
|
| 718 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.96
|
|
| 772 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.83
Deep-Palm: 0.86
|
|
| 777 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.91
|
|
| 807 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.98
|
|
| 823 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.94
|
|
| 827 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.75
|
|
| 833 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.79
|
|
| 838 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.88
|
|
| 942 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.92
|
|
| 1025 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.82
|
|
| 1026 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.74
|
|
| 1030 | - | - | - |
Deep-Palm: 0.68
|
|
| 1039 | - | - | - |
Deep-Palm: 0.68
|
|
| 1047 | - | - | - |
Deep-Palm: 0.56
|
|
| 1062 | - | - | - |
Deep-Palm: 0.91
|
|
| 1152 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.77
|
|
| 1289 | - | - | - |
Deep-Palm: 0.96
|
|
| 1300 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.78
|
|
| 1311 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.88
|
|
| 1358 | - | - | - |
Deep-Palm: 0.50
|
|
| 1441 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.97
|
|
| 1463 | - | - | - |
Deep-Palm: 0.97
|
|
| 1524 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.62
|
|
| 1595 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.87
Deep-Palm: 0.39
|
|
| 1708 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.89
|
|
| 1773 | - | - | - |
Deep-Palm: 0.24
|
|
| 1782 | - | - | - |
Deep-Palm: 0.45
|
|
| 1808 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 1837 | - | - | - |
Deep-Palm: 0.43
|
|
| 1889 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.97
|
|
| 1903 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.23
|
|
| 1907 | - | - | - |
Deep-Palm: 0.45
|
|
| 1961 | - | - | - |
Deep-Palm: 0.89
|
|
| 1976 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.95
|
|
| 1998 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.96
|
|
| 2013 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.94
|
|
| 2108 | - | - | - |
Deep-Palm: 0.93
|
|
| 2148 | - | - | - |
Deep-Palm: 0.96
|
|
| 2281 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.96
|
|
| 2282 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.97
|
|
| 2283 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.97
|
|
| 2305 | - | - | - |
Deep-Palm: 0.35
|
|
| 2310 | - | - | - |
Deep-Palm: 0.24
|
|
| 2360 | - | - | - |
Deep-Palm: 0.85
|
|
| 2526 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.95
|
|
| 2671 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.65
|
|
| 2747 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.97
|
|
| 2792 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.93
|
|
| 2820 | - | - | - |
Deep-Palm: 0.22
|
|
| 2833 | - | - | - |
Deep-Palm: 0.04
|
|
| 2859 | - | - | - |
Deep-Palm: 0.79
|
|
| 2877 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.97
|
|
| 2925 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.94
|
|
| 2971 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.97
|
|
| 3058 | - | - | - |
Deep-Palm: 0.83
|
|
| 3092 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.82
|
|
| 3132 | - | - | - |
Deep-Palm: 0.09
|
|
| 3142 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
U937 cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.667
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 135 | C → C | 0.001887 | SNP | Silent | UCEC |
| 150 | C → Y | 0.001969 | SNP | Missense Mutation | HNSC |
| 150 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 161 | S → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 184 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 515 | C → C | 0.002545 | SNP | Silent | GBM |
| 686 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 819 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 823 | C → C | 0.002288 | SNP | Silent | STAD |
| 1171 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1268 | R → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 1299 | S → C | 0.002545 | SNP | Missense Mutation | GBM |
| 1336 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1344 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1412 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1436 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1595 | C → S | 0.002294 | SNP | Missense Mutation | OV |
| 1647 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1704 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1773 | C → delins* | 0.001887 | INS | Nonsense Mutation | UCEC |
| 1862 | S → C | 0.002294 | SNP | Missense Mutation | OV |
| 1960 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1976 | C → F | 0.002976 | SNP | Missense Mutation | KIRC |
| 2006 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 2063 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 2063 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 2319 | A → Cfs*10 | 0.002288 | INS | Frame Shift Ins | STAD |
| 2461 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 2487 | S → C | 0.002288 | SNP | Missense Mutation | STAD |
| 2543 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 2888 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 3126 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |