Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P42892-2 | ECE1 | Endothelin-converting enzyme 1 (ECE-1) (EC … | Homo sapiens (Human) | 758 aa |
Protein Details: P42892-2 (ECE1)
Protein Information
| Accession | P42892-2 |
|---|---|
| Protein Names | Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) |
| Gene Symbol | ECE1 |
| Organism | Homo sapiens (Human) |
| Length | 758 aa |
| Isoforms | |
| Related PMIDs | 29575903 31251020 32651440 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPLQGLGLQR11NPFLQGKRGP21GLTSSPPLLP31PSLQVNFHSP41RSGQRCWAAR
51-10051TQVEKRLVVL61VVLLAAGLVA71CLAALGIQYQ81TRSPSVCLSE91ACVSVTSSIL
101-150101SSMDPTVDPC111HDFFSYACGG121WIKANPVPDG131HSRWGTFSNL141WEHNQAIIKH
151-200151LLENSTASVS161EAERKAQVYY171RACMNETRIE181ELRAKPLMEL191IERLGGWNIT
201-250201GPWAKDNFQD211TLQVVTAHYR221TSPFFSVYVS231ADSKNSNSNV241IQVDQSGLGL
251-300251PSRDYYLNKT261ENEKVLTGYL271NYMVQLGKLL281GGGDEEAIRP291QMQQILDFET
301-350301ALANITIPQE311KRRDEELIYH321KVTAAELQTL331APAINWLPFL341NTIFYPVEIN
351-400351ESEPIVVYDK361EYLEQISTLI371NTTDRCLLNN381YMIWNLVRKT391SSFLDQRFQD
401-450401ADEKFMEVMY411GTKKTCLPRW421KFCVSDTENN431LGFALGPMFV441KATFAEDSKS
451-500451IATEIILEIK461KAFEESLSTL471KWMDEETRKS481AKEKADAIYN491MIGYPNFIMD
501-550501PKELDKVFND511YTAVPDLYFE521NAMRFFNFSW531RVTADQLRKA541PNRDQWSMTP
551-600551PMVNAYYSPT561KNEIVFPAGI571LQAPFYTRSS581PKALNFGGIG591VVVGHELTHA
601-650601FDDQGREYDK611DGNLRPWWKN621SSVEAFKRQT631ECMVEQYSNY641SVNGEPVNGR
651-700651HTLGENIADN661GGLKAAYRAY671QNWVKKNGAE681HSLPTLGLTN691NQLFFLGFAQ
701-750701VWCSVRTPES711SHEGLITDPH721SPSRFRVIGS731LSNSKEFSEH741FRCPPGSPMN
751-758751PPHKCEVW
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 46 | - |
HeLa
(29575903)
| - | - | |
| 58 | - | - | - |
Deep-Palm: 0.95
|
|
| 83 | - | - | - |
Deep-Palm: 0.98
|
|
| 99 | - | - | - |
Deep-Palm: 0.90
|
|
| 104 | - | - | - |
Deep-Palm: 0.74
|
|
| 122 | - | - | - |
Deep-Palm: 0.09
|
|
| 130 | - | - | - |
Deep-Palm: 0.11
|
|
| 185 | - | - | - |
Deep-Palm: 0.96
|
|
| 388 | - | - | - |
Deep-Palm: 0.24
|
|
| 423 | - | - | - |
GPS-Palm: 0.92
|
|
| 428 | - | - | - |
Deep-Palm: 0.36
|
|
| 435 | - | - | - |
Deep-Palm: 0.67
|
|
| 644 | - | - | - |
Deep-Palm: 0.12
|
|
| 715 | - | - | - |
Deep-Palm: 0.57
|
|
| 755 | - | - | - |
Deep-Palm: 0.63
|
|
| 767 | - | - | - |
Deep-Palm: 0.01
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
1
LNCaP
Specificity: 0.333
1/1 (100.0%)
1
HeLa cell
Specificity: 0.333
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 83 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 83 | C → F | 0.002141 | SNP | Missense Mutation | SKCM |
| 104 | C → C | 0.002288 | SNP | Silent | STAD |
| 183 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 208 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 232 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 409 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 509 | F → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 630 | W → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 736 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 767 | C → C | 0.002506 | SNP | Silent | COAD |