Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P46087-4 | NOP2 | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) … | Homo sapiens (Human) | 845 aa |
Protein Details: P46087-4 (NOP2)
Protein Information
| Accession | P46087-4 |
|---|---|
| Protein Names | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) |
| Gene Symbol | NOP2 |
| Organism | Homo sapiens (Human) |
| Length | 845 aa |
| Isoforms | |
| Related PMIDs | 31251020 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGRKLDPTKE11KRGPGRKARK21QKGAETELVR31FLPAVSDENS41KRLSSRARKR
51-10051AAKRRLGSVE61APKTNKSPEA71KPLPGKLPKG81ISAGAVQTAG91KKGPQSLFNA
101-150101PRGKKRPAPG111SDEEEEEEDS121EEDGMVNHGD131LWGSEDDADT141VDDYGADSNS
151-200151EDEEEGEAAG161VQWLGLGSLQ171PPPPGFKQFS181CLSFPSSWDL191QLLPIERAAR
201-250201KQKAREAAAG211IQWSEEETED221EEEEKEVTPE231SGPPKVEEAD241GGLQINVDEE
251-300251PFVLPPAGEM261EQDAQAPDLQ271RVHKRIQDIV281GILRDFGAQR291EEGRSRSEYL
301-350301NRLKKDLAIY311YSYGDFLLGK321LMDLFPLSEL331VEFLEANEVP341RPVTLRTNTL
351-400351KTRRRDLAQA361LINRGVNLDP371LGKWSKTGLV381VYDSSVPIGA391TPEYLAGHYM
401-450401LQGASSMLPV411MALAPQEHER421ILDMCCAPGG431KTSYMAQLMK441NTGVILANDA
451-500451NAERLKSVVG461NLHRLGVTNT471IISHYDGRQF481PKVVGGFDRV491LLDAPCSGTG
501-550501VISKDPAVKT511NKDEKDILRC521AHLQKELLLS531AIDSVNATSK541TGGYLVYCTC
551-600551SITVEENEWV561VDYALKKRNV571RLVPTGLDFG581QEGFTRFRER591RFHPSLRSTR
601-650601RFYPHTHNMD611GFFIAKFKKF621SNSIPQSQTG631NSETATPTNV641DLPQVIPKSE
651-700651NSSQPAKKAK661GAAKTKQQLQ671KQQHPKKASF681QKLNGISKGA691DSELSTVPSV
701-750701TKTQASSSFQ711DSSQPAGKAE721GIREPKVTGK731LKQRSPKLQS741SKKVAFLRQN
751-800751APPKGTDTQT761PAVLSPSKTQ771ATLKPKDHHQ781PLGRAKGVEK791QQLPEQPFEK
801-845801AAFQKQNDTP811KGPQPPTVSP821IRSSRPPPAK831RKKSQSRGNS841QLLLS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 392 | - | - | - |
Deep-Palm: 0.85
|
|
| 393 | - | - | - |
Deep-Palm: 0.80
|
|
| 463 | - | - | - |
Deep-Palm: 0.98
|
|
| 487 | - | - | - |
Deep-Palm: 0.93
|
|
| 515 | - | - | - |
Deep-Palm: 0.66
|
|
| 517 | - | - | - |
Deep-Palm: 0.79
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 331 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 445 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 463 | C → Y | 0.002033 | SNP | Missense Mutation | LUSC |
| 470 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 487 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 564 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 570 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 594 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |