Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P46777 RPL5; MSTP030 Large ribosomal subunit protein uL18 … Homo sapiens (Human) 297 aa

Protein Details: P46777 (RPL5)

Protein Information
Accession P46777
Protein Names Large ribosomal subunit protein uL18 (60S ribosomal protein L5)
Gene Symbol RPL5; MSTP030
Organism Homo sapiens (Human)
Length 297 aa
Isoforms No isoforms
Related PMIDs 19801377 21076176 24357059 29575903 29733200 31251020 31382980 32944167 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.562
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.562
36/46 (78.3%)
10
HAP1 cells
Specificity: 0.156
10/10 (100.0%)
4
Jurkat T cells
Specificity: 0.062
4/25 (16.0%)
4
293T cells
Specificity: 0.062
4/10 (40.0%)
3
PC3 cells
Specificity: 0.047
3/4 (75.0%)
2
DU145 cells
Specificity: 0.031
2/2 (100.0%)
2
Cerebral cortex
Specificity: 0.031
2/4 (50.0%)
1
U937 cells
Specificity: 0.016
1/1 (100.0%)
1
HeLa cells
Specificity: 0.016
1/1 (100.0%)
1
Endothelial cells
Specificity: 0.016
1/2 (50.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGFVKVVKNK11AYFKRYQVKF21RRRREGKTDY31YARKRLVIQD41KNKYNTPKYR
51-10051MIVRVTNRDI61ICQIAYARIE71GDMIVCAAYA81HELPKYGVKV91GLTNYAAAYC
101-150101TGLLLARRLL111NRFGMDKIYE121GQVEVTGDEY131NVESIDGQPG141AFTCYLDAGL
151-200151ARTTTGNKVF161GALKGAVDGG171LSIPHSTKRF181PGYDSESKEF191NAEVHRKHIM
201-250201GQNVADYMRY211LMEEDEDAYK221KQFSQYIKNS231VTPDMMEEMY241KKAHAAIREN
251-297251PVYEKKPKKE261VKKKRWNRPK271MSLAQKKDRV281AQKKASFLRA291QERAAES
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
62 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) Ribosomal large subunit proteins 60S L5 and 50S L18 29575903
76 Prediction (Low) - -
100 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) Ribosomal large subunit proteins 60S L5 and 50S L18 29575903
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
54 R → C 0.001014 SNP Missense Mutation BRCA
54 R → C 0.006424 SNP Missense Mutation SKCM
62 C → Y 0.002545 SNP Missense Mutation GBM
100 C → F 0.004219 SNP Missense Mutation SARC
113 F → C 0.002141 SNP Missense Mutation SKCM
137 G → C 0.001887 SNP Missense Mutation UCEC
144 C → C 0.001887 SNP Silent UCEC
? ? → ? 0.002427 SNP Missense Mutation BLCA