Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P46777 | RPL5 | Large ribosomal subunit protein uL18 … | Homo sapiens (Human) | 297 aa |
Protein Details: P46777 (RPL5)
Protein Information
| Accession | P46777 |
|---|---|
| Protein Names | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) |
| Gene Symbol | RPL5 |
| Organism | Homo sapiens (Human) |
| Length | 297 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 29733200 31251020 31382980 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGFVKVVKNK11AYFKRYQVKF21RRRREGKTDY31YARKRLVIQD41KNKYNTPKYR
51-10051MIVRVTNRDI61ICQIAYARIE71GDMIVCAAYA81HELPKYGVKV91GLTNYAAAYC
101-150101TGLLLARRLL111NRFGMDKIYE121GQVEVTGDEY131NVESIDGQPG141AFTCYLDAGL
151-200151ARTTTGNKVF161GALKGAVDGG171LSIPHSTKRF181PGYDSESKEF191NAEVHRKHIM
201-250201GQNVADYMRY211LMEEDEDAYK221KQFSQYIKNS231VTPDMMEEMY241KKAHAAIREN
251-297251PVYEKKPKKE261VKKKRWNRPK271MSLAQKKDRV281AQKKASFLRA291QERAAES
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 62 | SWISSPALM DBPTM CYSMODDB | Ribosomal large subunit proteins 60S L5 and 50S L18 |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.70
|
| 76 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.70
Deep-Palm: 0.84
|
|
| 100 | SWISSPALM DBPTM CYSMODDB | Ribosomal large subunit proteins 60S L5 and 50S L18 | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.91
Deep-Palm: 0.97
|
| 144 | - | - | - |
Deep-Palm: 0.83
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
3
LNCaP
Specificity: 0.300
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.200
2/2 (100.0%)
1
U937 cell
Specificity: 0.100
1/1 (100.0%)
1
293T cell
Specificity: 0.100
1/1 (100.0%)
1
HUVECs
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.200
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 54 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 54 | R → C | 0.006424 | SNP | Missense Mutation | SKCM |
| 62 | C → Y | 0.002545 | SNP | Missense Mutation | GBM |
| 100 | C → F | 0.004219 | SNP | Missense Mutation | SARC |
| 113 | F → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 137 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 144 | C → C | 0.001887 | SNP | Silent | UCEC |
| ? | ? → ? | 0.002427 | SNP | Missense Mutation | BLCA |