Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P48668 | KRT6C | Keratin, type II cytoskeletal 6C … | Homo sapiens (Human) | 564 aa |
Protein Details: P48668 (KRT6C)
Protein Information
| Accession | P48668 |
|---|---|
| Protein Names | Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12) |
| Gene Symbol | KRT6C |
| Organism | Homo sapiens (Human) |
| Length | 564 aa |
| Isoforms | No isoforms |
| Related PMIDs | 25914232 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASTSTTIRS11HSSSRRGFSA21NSARLPGVSR31SGFSSISVSR41SRGSGGLGGA
51-10051CGGAGFGSRS61LYGLGGSKRI71SIGGGSCAIS81GGYGSRAGGS91YGFGGAGSGF
101-150101GFGGGAGIGF111GLGGGAGLAG121GFGGPGFPVC131PPGGIQEVTV141NQSLLTPLNL
151-200151QIDPAIQRVR161AEEREQIKTL171NNKFASFIDK181VRFLEQQNKV191LDTKWTLLQE
201-250201QGTKTVRQNL211EPLFEQYINN221LRRQLDSIVG231ERGRLDSELR241NMQDLVEDLK
251-300251NKYEDEINKR261TAAENEFVTL271KKDVDAAYMN281KVELQAKADT291LTDEINFLRA
301-350301LYDAELSQMQ311THISDTSVVL321SMDNNRNLDL331DSIIAEVKAQ341YEEIAQRSRA
351-400351EAESWYQTKY361EELQVTAGRH371GDDLRNTKQE381IAEINRMIQR391LRSEIDHVKK
401-450401QCASLQAAIA411DAEQRGEMAL421KDAKNKLEGL431EDALQKAKQD441LARLLKEYQE
451-500451LMNVKLALDV461EIATYRKLLE471GEECRLNGEG481VGQVNVSVVQ491STISSGYGGA
501-550501SGVGSGLGLG511GGSSYSYGSG521LGIGGGFSSS531SGRAIGGGLS541SVGGGSSTIK
551-564551YTTTSSSSRK561SYKH
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 51 | - | - |
Brain
(35358180)
Brain
(31311849)
cerebral cortex
(36430497)
|
Deep-Palm: 0.98
|
|
| 77 | - | - |
Brain
(35358180)
cerebral cortex
(36430497)
|
Deep-Palm: 0.97
|
|
| 130 | - | - | - |
Deep-Palm: 0.95
|
|
| 402 | - | - | - |
Deep-Palm: 0.93
|
|
| 474 | - | - |
Liver
(37925639)
Brain
(35358180)
Brain
(31311849)
cerebral cortex
(36430497)
|
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
CEM 174 cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
2
LNCaP cells (Mass)
Specificity: 0.400
2/4 (50.0%)
2
Cerebral Cortex (Mass)
Specificity: 0.400
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 17 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 40 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 234 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 260 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 505 | S → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 517 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 530 | S → C | 0.002747 | SNP | Missense Mutation | LIHC |