Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P48668 | KRT6C; KRT6E | Keratin, type II cytoskeletal 6C … | Homo sapiens (Human) | 564 aa |
Protein Details: P48668 (KRT6C)
Protein Information
| Accession | P48668 |
|---|---|
| Protein Names | Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12) |
| Gene Symbol | KRT6C; KRT6E |
| Organism | Homo sapiens (Human) |
| Length | 564 aa |
| Isoforms | No isoforms |
| Related PMIDs | 25914232 29733200 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.857
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
6
HAP1 cells
Specificity: 0.857
6/10 (60.0%)
1
CEMx174 cells
Specificity: 0.143
1/3 (33.3%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MASTSTTIRS11HSSSRRGFSA21NSARLPGVSR31SGFSSISVSR41SRGSGGLGGA
51-10051CGGAGFGSRS61LYGLGGSKRI71SIGGGSCAIS81GGYGSRAGGS91YGFGGAGSGF
101-150101GFGGGAGIGF111GLGGGAGLAG121GFGGPGFPVC131PPGGIQEVTV141NQSLLTPLNL
151-200151QIDPAIQRVR161AEEREQIKTL171NNKFASFIDK181VRFLEQQNKV191LDTKWTLLQE
201-250201QGTKTVRQNL211EPLFEQYINN221LRRQLDSIVG231ERGRLDSELR241NMQDLVEDLK
251-300251NKYEDEINKR261TAAENEFVTL271KKDVDAAYMN281KVELQAKADT291LTDEINFLRA
301-350301LYDAELSQMQ311THISDTSVVL321SMDNNRNLDL331DSIIAEVKAQ341YEEIAQRSRA
351-400351EAESWYQTKY361EELQVTAGRH371GDDLRNTKQE381IAEINRMIQR391LRSEIDHVKK
401-450401QCASLQAAIA411DAEQRGEMAL421KDAKNKLEGL431EDALQKAKQD441LARLLKEYQE
451-500451LMNVKLALDV461EIATYRKLLE471GEECRLNGEG481VGQVNVSVVQ491STISSGYGGA
501-550501SGVGSGLGLG511GGSSYSYGSG521LGIGGGFSSS531SGRAIGGGLS541SVGGGSSTIK
551-564551YTTTSSSSRK561SYKH
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 51 | Prediction (Medium) | - | - |
| 77 | Prediction (Medium) | - | - |
| 130 | Prediction (Low) | - | - |
| 402 | Prediction (Low) | - | - |
| 474 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 17 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 40 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 234 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 260 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 505 | S → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 517 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 530 | S → C | 0.002747 | SNP | Missense Mutation | LIHC |