Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P49137 | MAPKAPK2 | MAP kinase-activated protein kinase 2 … | Homo sapiens (Human) | 400 aa |
Protein Details: P49137 (MAPKAPK2)
Protein Information
| Accession | P49137 |
|---|---|
| Protein Names | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) |
| Gene Symbol | MAPKAPK2 |
| Organism | Homo sapiens (Human) |
| Length | 400 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLSNSQGQSP11PVPFPAPAPP21PQPPTPALPH31PPAQPPPPPP41QQFPQFHVKS
51-10051GLQIKKNAII61DDYKVTSQVL71GLGINGKVLQ81IFNKRTQEKF91ALKMLQDCPK
101-150101ARREVELHWR111ASQCPHIVRI121VDVYENLYAG131RKCLLIVMEC141LDGGELFSRI
151-200151QDRGDQAFTE161REASEIMKSI171GEAIQYLHSI181NIAHRDVKPE191NLLYTSKRPN
201-250201AILKLTDFGF211AKETTSHNSL221TTPCYTPYYV231APEVLGPEKY241DKSCDMWSLG
251-300251VIMYILLCGY261PPFYSNHGLA271ISPGMKTRIR281MGQYEFPNPE291WSEVSEEVKM
301-350301LIRNLLKTEP311TQRMTITEFM321NHPWIMQSTK331VPQTPLHTSR341VLKEDKERWE
351-400351DVKEEMTSAL361ATMRVDYEQI371KIKKIEDASN381PLLLKRRKKA391RALEAAALAH
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 98 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.97
|
| 114 | - | - | - |
Deep-Palm: 0.70
|
|
| 133 | - | - | - |
Deep-Palm: 0.69
|
|
| 140 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.83
|
|
| 224 | - | - | - |
Deep-Palm: 0.60
|
|
| 244 | - | - | - |
Deep-Palm: 0.22
|
|
| 258 | - | - | - |
Deep-Palm: 0.06
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 244 | C → Y | 0.012500 | SNP | Missense Mutation | UVM |
| 278 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |