Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P49327 | FASN | Fatty acid synthase (EC 2.3.1.85) … | Homo sapiens (Human) | 2511 aa |
Protein Details: P49327 (FASN)
Protein Information
| Accession | P49327 |
|---|---|
| Protein Names | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] |
| Gene Symbol | FASN |
| Organism | Homo sapiens (Human) |
| Length | 2511 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 24357059 29575903 29733200 31251020 31382980 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEEVVIAGMS11GKLPESENLQ21EFWDNLIGGV31DMVTDDDRRW41KAGLYGLPRR
51-10051SGKLKDLSRF61DASFFGVHPK71QAHTMDPQLR81LLLEVTYEAI91VDGGINPDSL
101-150101RGTHTGVWVG111VSGSETSEAL121SRDPETLVGY131SMVGCQRAMM141ANRLSFFFDF
151-200151RGPSIALDTA161CSSSLMALQN171AYQAIHSGQC181PAAIVGGINV191LLKPNTSVQF
201-250201LRLGMLSPEG211TCKAFDTAGN221GYCRSEGVVA231VLLTKKSLAR241RVYATILNAG
251-300251TNTDGFKEQG261VTFPSGDIQE271QLIRSLYQSA281GVAPESFEYI291EAHGTGTKVG
301-350301DPQELNGITR311ALCATRQEPL321LIGSTKSNMG331HPEPASGLAA341LAKVLLSLEH
351-400351GLWAPNLHFH361SPNPEIPALL371DGRLQVVDQP381LPVRGGNVGI391NSFGFGGSNV
401-450401HIILRPNTQP411PPAPAPHATL421PRLLRASGRT431PEAVQKLLEQ441GLRHSQDLAF
451-500451LSMLNDIAAV461PATAMPFRGY471AVLGGERGGP481EVQQVPAGER491PLWFICSGMG
501-550501TQWRGMGLSL511MRLDRFRDSI521LRSDEAVKPF531GLKVSQLLLS541TDESTFDDIV
551-600551HSFVSLTAIQ561IGLIDLLSCM571GLRPDGIVGH581SLGEVACGYA591DGCLSQEEAV
601-650601LAAYWRGQCI611KEAHLPPGAM621AAVGLSWEEC631KQRCPPGVVP641ACHNSKDTVT
651-700651ISGPQAPVFE661FVEQLRKEGV671FAKEVRTGGM681AFHSYFMEAI691APPLLQELKK
701-750701VIREPKPRSA711RWLSTSIPEA721QWHSSLARTS731SAEYNVNNLV741SPVLFQEALW
751-800751HVPEHAVVLE761IAPHALLQAV771LKRGLKPSCT781IIPLMKKDHR791DNLEFFLAGI
801-850801GRLHLSGIDA811NPNALFPPVE821FPAPRGTPLI831SPLIKWDHSL841AWDVPAAEDF
851-900851PNGSGSPSAA861IYNIDTSSES871PDHYLVDHTL881DGRVLFPATG891YLSIVWKTLA
901-950901RALGLGVEQL911PVVFEDVVLH921QATILPKTGT931VSLEVRLLEA941SRAFEVSENG
951-1000951NLVVSGKVYQ961WDDPDPRLFD971HPESPTPNPT981EPLFLAQAEV991YKELRLRGYD
1001-10501001YGPHFQGILE1011ASLEGDSGRL1021LWKDNWVSFM1031DTMLQMSILG1041SAKHGLYLPT
1051-11001051RVTAIHIDPA1061THRQKLYTLQ1071DKAQVADVVV1081SRWLRVTVAG1091GVHISGLHTE
1101-11501101SAPRRQQEQQ1111VPILEKFCFT1121PHTEEGCLSE1131RAALQEELQL1141CKGLVQALQT
1151-12001151KVTQQGLKMV1161VPGLDGAQIP1171RDPSQQELPR1181LLSAACRLQL1191NGNLQLELAQ
1201-12501201VLAQERPKLP1211EDPLLSGLLD1221SPALKACLDT1231AVENMPSLKM1241KVVEVLAGHG
1251-13001251HLYSRIPGLL1261SPHPLLQLSY1271TATDRHPQAL1281EAAQAELQQH1291DVAQGQWDPA
1301-13501301DPAPSALGSA1311DLLVCNCAVA1321ALGDPASALS1331NMVAALREGG1341FLLLHTLLRG
1351-14001351HPLGDIVAFL1361TSTEPQYGQG1371ILSQDAWESL1381FSRVSLRLVG1391LKKSFYGSTL
1401-14501401FLCRRPTPQD1411SPIFLPVDDT1421SFRWVESLKG1431ILADEDSSRP1441VWLKAINCAT
1451-15001451SGVVGLVNCL1461RREPGGNRLR1471CVLLSNLSST1481SHVPEVDPGS1491AELQKVLQGD
1501-15501501LVMNVYRDGA1511WGAFRHFLLE1521EDKPEEPTAH1531AFVSTLTRGD1541LSSIRWVCSS
1551-16001551LRHAQPTCPG1561AQLCTVYYAS1571LNFRDIMLAT1581GKLSPDAIPG1591KWTSQDSLLG
1601-16501601MEFSGRDASG1611KRVMGLVPAK1621GLATSVLLSP1631DFLWDVPSNW1641TLEEAASVPV
1651-17001651VYSTAYYALV1661VRGRVRPGET1671LLIHSGSGGV1681GQAAIAIALS1691LGCRVFTTVG
1701-17501701SAEKRAYLQA1711RFPQLDSTSF1721ANSRDTSFEQ1731HVLWHTGGKG1741VDLVLNSLAE
1751-18001751EKLQASVRCL1761ATHGRFLEIG1771KFDLSQNHPL1781GMAIFLKNVT1791FHGVLLDAFF
1801-18501801NESSADWREV1811WALVQAGIRD1821GVVRPLKCTV1831FHGAQVEDAF1841RYMAQGKHIG
1851-19001851KVVVQVLAEE1861PEAVLKGAKP1871KLMSAISKTF1881CPAHKSYIIA1891GGLGGFGLEL
1901-19501901AQWLIQRGVQ1911KLVLTSRSGI1921RTGYQAKQVR1931RWRRQGVQVQ1941VSTSNISSLE
1951-20001951GARGLIAEAA1961QLGPVGGVFN1971LAVVLRDGLL1981ENQTPEFFQD1991VCKPKYSGTL
2001-20502001NLDRVTREAC2011PELDYFVVFS2021SVSCGRGNAG2031QSNYGFANSA2041MERICEKRRH
2051-21002051EGLPGLAVQW2061GAIGDVGILV2071ETMSTNDTIV2081SGTLPQRMAS2091CLEVLDLFLN
2101-21502101QPHMVLSSFV2111LAEKAAAYRD2121RDSQRDLVEA2131VAHILGIRDL2141AAVNLDSSLA
2151-22002151DLGLDSLMSV2161EVRQTLEREL2171NLVLSVREVR2181QLTLRKLQEL2191SSKADEASEL
2201-22502201ACPTPKEDGL2211AQQQTQLNLR2221SLLVNPEGPT2231LMRLNSVQSS2241ERPLFLVHPI
2251-23002251EGSTTVFHSL2261ASRLSIPTYG2271LQCTRAAPLD2281SIHSLAAYYI2291DCIRQVQPEG
2301-23502301PYRVAGYSYG2311ACVAFEMCSQ2321LQAQQSPAPT2331HNSLFLFDGS2341PTYVLAYTQS
2351-24002351YRAKLTPGCE2361AEAETEAICF2371FVQQFTDMEH2381NRVLEALLPL2391KGLEERVAAA
2401-24502401VDLIIKSHQG2411LDRQELSFAA2421RSFYYKLRAA2431EQYTPKAKYH2441GNVMLLRAKT
2451-25002451GGAYGEDLGA2461DYNLSQVCDG2471KVSVHVIEGD2481HRTLLEGSGL2491ESIISIIHSS
2501-25112501LAEPRVSVRE2511G
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 135 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.82
|
|
| 161 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.71
|
|
| 180 | - | - | - |
Deep-Palm: 0.95
|
|
| 212 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.67
Deep-Palm: 0.94
|
|
| 223 | - |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.71
Deep-Palm: 0.95
|
|
| 313 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.96
|
|
| 496 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.85
|
|
| 569 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.88
|
|
| 587 | - | - | - |
Deep-Palm: 0.81
|
|
| 593 | - | - | - |
Deep-Palm: 0.81
|
|
| 609 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.92
|
|
| 630 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.70
|
|
| 634 | SWISSPALM DBPTM CYSMODDB | Acyl transferase domain | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.42
|
| 642 | SWISSPALM DBPTM CYSMODDB | Acyl transferase domain | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.64
|
| 779 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
|
| 1118 | - | - | - |
Deep-Palm: 0.77
|
|
| 1127 | - | - | - |
Deep-Palm: 0.95
|
|
| 1141 | SWISSPALM DBPTM CYSMODDB | - |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.93
Deep-Palm: 0.97
|
| 1186 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.97
|
|
| 1227 | - |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.74
Deep-Palm: 0.98
|
|
| 1315 | - | - | - |
Deep-Palm: 0.98
|
|
| 1317 | - | - | - |
Deep-Palm: 0.98
|
|
| 1403 | SWISSPALM DBPTM CYSMODDB | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.71
Deep-Palm: 0.93
|
| 1448 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.97
|
|
| 1459 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.97
|
|
| 1471 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.81
Deep-Palm: 0.97
|
|
| 1548 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.82
|
|
| 1558 | - | - | - |
Deep-Palm: 0.32
|
|
| 1564 | - | - | - |
Deep-Palm: 0.41
|
|
| 1693 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.89
Deep-Palm: 0.98
|
|
| 1759 | - | - | - |
Deep-Palm: 0.98
|
|
| 1828 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.71
Deep-Palm: 0.94
|
|
| 1881 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.85
Deep-Palm: 0.93
|
|
| 1992 | - | - | - |
Deep-Palm: 0.94
|
|
| 2010 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.89
|
|
| 2024 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.92
|
|
| 2045 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.95
|
|
| 2091 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.92
|
|
| 2202 | SWISSPALM DBPTM CYSMODDB | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
Deep-Palm: 0.92
|
| 2273 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.91
|
|
| 2292 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.56
|
|
| 2312 | - | - | - |
Deep-Palm: 0.53
|
|
| 2318 | - | - | - |
Deep-Palm: 0.36
|
|
| 2359 | - | - | - |
Deep-Palm: 0.90
|
|
| 2369 | - | - | - |
Deep-Palm: 0.33
|
|
| 2468 | - | - | - |
Deep-Palm: 0.76
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.267
4
LNCaP
Specificity: 0.211
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.211
4/4 (100.0%)
2
HAP1 cell
Specificity: 0.105
2/2 (100.0%)
1
U937 cell
Specificity: 0.053
1/1 (100.0%)
1
HeLa cell
Specificity: 0.053
1/1 (100.0%)
1
EC cell
Specificity: 0.053
1/1 (100.0%)
1
293T cell
Specificity: 0.053
1/1 (100.0%)
1
HUVECs
Specificity: 0.053
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.211
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 87 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 129 | G → C | 0.002288 | SNP | Missense Mutation | STAD |
| 384 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 490 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 504 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 605 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 642 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 901 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1127 | C → C | 0.001887 | SNP | Silent | UCEC |
| 1131 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1141 | C → F | 0.007299 | SNP | Missense Mutation | READ |
| 1421 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1545 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1567 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1841 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1917 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 2045 | C → Afs*26 | 0.001014 | DEL | Frame Shift Del | BRCA |
| 2177 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 2202 | C → Y | 0.002033 | SNP | Missense Mutation | LUSC |
| 2292 | C → S | 0.001887 | SNP | Missense Mutation | UCEC |
| 2413 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |