Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P49736 | MCM2; BM28; CCNL1; CDCL1; KIAA0030 | DNA replication licensing factor MCM2 … | Homo sapiens (Human) | 904 aa |
Protein Details: P49736 (MCM2)
Protein Information
| Accession | P49736 |
|---|---|
| Protein Names | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) |
| Gene Symbol | MCM2; BM28; CCNL1; CDCL1; KIAA0030 |
| Organism | Homo sapiens (Human) |
| Length | 904 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 29733200 31251020 31382980 32944167 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.594
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
19
LNCaP cells
Specificity: 0.594
19/46 (41.3%)
6
HAP1 cells
Specificity: 0.188
6/10 (60.0%)
4
Jurkat T cells
Specificity: 0.125
4/25 (16.0%)
2
PC3 cells
Specificity: 0.062
2/4 (50.0%)
1
U937 cells
Specificity: 0.031
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAESSESFTM11ASSPAQRRRG21NDPLTSSPGR31SSRRTDALTS41SPGRDLPPFE
51-10051DESEGLLGTE61GPLEEEEDGE71ELIGDGMERD81YRAIPELDAY91EAEGLALDDE
101-150101DVEELTASQR111EAAERAMRQR121DREAGRGLGR131MRRGLLYDSD141EEDEERPARK
151-200151RRQVERATED161GEEDEEMIES171IENLEDLKGH181SVREWVSMAG191PRLEIHHRFK
201-250201NFLRTHVDSH211GHNVFKERIS221DMCKENRESL231VVNYEDLAAR241EHVLAYFLPE
251-300251APAELLQIFD261EAALEVVLAM271YPKYDRITNH281IHVRISHLPL291VEELRSLRQL
301-350301HLNQLIRTSG311VVTSCTGVLP321QLSMVKYNCN331KCNFVLGPFC341QSQNQEVKPG
351-400351SCPECQSAGP361FEVNMEETIY371QNYQRIRIQE381SPGKVAAGRL391PRSKDAILLA
401-450401DLVDSCKPGD411EIELTGIYHN421NYDGSLNTAN431GFPVFATVIL441ANHVAKKDNK
451-500451VAVGELTDED461VKMITSLSKD471QQIGEKIFAS481IAPSIYGHED491IKRGLALALF
501-550501GGEPKNPGGK511HKVRGDINVL521LCGDPGTAKS531QFLKYIEKVS541SRAIFTTGQG
551-600551ASAVGLTAYV561QRHPVSREWT571LEAGALVLAD581RGVCLIDEFD591KMNDQDRTSI
601-650601HEAMEQQSIS611ISKAGIVTSL621QARCTVIAAA631NPIGGRYDPS641LTFSENVDLT
651-700651EPIISRFDIL661CVVRDTVDPV671QDEMLARFVV681GSHVRHHPSN691KEEEGLANGS
701-750701AAEPAMPNTY711GVEPLPQEVL721KKYIIYAKER731VHPKLNQMDQ741DKVAKMYSDL
751-800751RKESMATGSI761PITVRHIESM771IRMAEAHARI781HLRDYVIEDD791VNMAIRVMLE
801-850801SFIDTQKFSV811MRSMRKTFAR821YLSFRRDNNE831LLLFILKQLV841AEQVTYQRNR
851-900851FGAQQDTIEV861PEKDLVDKAR871QINIHNLSAF881YDSELFRMNK891FSHDLKRKMI
901-904901LQQF
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 315 | Prediction (Medium) | - | - |
| 329 | Prediction (Low) | - | - |
| 406 | Prediction (Low) | - | - |
| 522 | Prediction (Medium) | - | - |
| 584 | Prediction (High) | - | - |
| 624 | Prediction (Low) | - | - |
| 661 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 132 | C → C | 0.001887 | SNP | Silent | UCEC |
| 195 | C → Y | 0.001969 | SNP | Missense Mutation | HNSC |
| 198 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 264 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 264 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 284 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 402 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 431 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 471 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 471 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 499 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 499 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 522 | C → C | 0.001887 | SNP | Silent | UCEC |
| 526 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 779 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 812 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 812 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 826 | R → C | 0.002545 | SNP | Missense Mutation | GBM |