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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P49757 NUMB Protein numb homolog (h-Numb) (Protein … Homo sapiens (Human) 651 aa

Protein Details: P49757 (NUMB)

Protein Information
AccessionP49757
Protein NamesProtein numb homolog (h-Numb) (Protein S171)
Gene SymbolNUMB
OrganismHomo sapiens (Human)
Length651 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MNKLRQSFRR11KKDVYVPEAS21RPHQWQTDEE31GVRTGKCSFP41VKYLGHVEVD
51-10051ESRGMHICED61AVKRLKAERK71FFKGFFGKTG81KKAVKAVLWV91SADGLRVVDE
101-150101KTKDLIVDQT111IEKVSFCAPD121RNFDRAFSYI131CRDGTTRRWI141CHCFMAVKDT
151-200151GERLSHAVGC161AFAACLERKQ171KREKECGVTA181TFDASRTTFT191REGSFRVTTA
201-250201TEQAEREEIM211KQMQDAKKAE221TDKIVVGSSV231APGNTAPSPS241SPTSPTSDAT
251-300251TSLEMNNPHA261IPRRHAPIEQ271LARQGSFRGF281PALSQKMSPF291KRQLSLRINE
301-350301LPSTMQRKTD311FPIKNAVPEV321EGEAESISSL331CSQITNAFST341PEDPFSSAPM
351-400351TKPVTVVAPQ361SPTFQANGTD371SAFHVLAKPA381HTALAPVAMP391VRETNPWAHA
401-450401PDAANKEIAA411TCSGTEWGQS421SGAASPGLFQ431AGHRRTPSEA441DRWLEEVSKS
451-500451VRAQQPQASA461APLQPVLQPP471PPTAISQPAS481PFQGNAFLTS491QPVPVGVVPA
501-550501LQPAFVPAQS511YPVANGMPYP521APNVPVVGIT531PSQMVANVFG541TAGHPQAAHP
551-600551HQSPSLVRQQ561TFPHYEASSA571TTSPFFKPPA581QHLNGSAAFN591GVDDGRLASA
601-650601DRHTEVPTGT611CPVDPFEAQW621AALENKSKQR631TNPSPTNPFS641SDLQKTFEIE
651-651651L
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
37 DBPTM SWISSPALM PH domain-like Numb/numb-like PH-like domain superfamily - -
Deep-Palm: 0.55
58 - - -
GPS-Palm: 0.82
Deep-Palm: 0.95
117 - - -
GPS-Palm: 0.76
Deep-Palm: 0.45
131 - - -
GPS-Palm: 0.77
Deep-Palm: 0.07
141 - - -
GPS-Palm: 0.81
Deep-Palm: 0.29
143 - - -
GPS-Palm: 0.80
Deep-Palm: 0.31
160 DBPTM SWISSPALM Phosphotyrosine interaction domain (PTB/PID) - -
GPS-Palm: 0.83
Deep-Palm: 0.96
165 DBPTM SWISSPALM - - -
GPS-Palm: 0.88
Deep-Palm: 0.96
176 - - -
GPS-Palm: 0.82
Deep-Palm: 0.93
331 - - -
Deep-Palm: 0.91
412 - - -
Deep-Palm: 0.81
611 - - -
Deep-Palm: 0.87
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
137 R → C 0.001887 SNP Missense Mutation UCEC
168 R → C 0.002545 SNP Missense Mutation GBM
196 R → C 0.003774 SNP Missense Mutation UCEC
292 R → C 0.003460 SNP Missense Mutation CESC
297 R → C 0.001887 SNP Missense Mutation UCEC
373 F → C 0.002747 SNP Missense Mutation LIHC
392 R → C 0.001014 SNP Missense Mutation BRCA
576 F → C 0.001887 SNP Missense Mutation UCEC
609 G → C 0.002506 SNP Missense Mutation COAD