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UniProt ID Gene Symbol Protein Name Organism Length Action
P49798 RGS4 Regulator of G-protein signaling 4 … Homo sapiens (Human) 205 aa

Protein Details: P49798 (RGS4)

Protein Information
AccessionP49798
Protein NamesRegulator of G-protein signaling 4 (RGP4) (RGS4)
Gene SymbolRGS4
OrganismHomo sapiens (Human)
Length205 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MCKGLAGLPA11SCLRSAKDMK21HRLGFLLQKS31DSCEHNSSHN41KKDKVVICQR
51-10051VSQEEVKKWA61ESLENLISHE71CGLAAFKAFL81KSEYSEENID91FWISCEEYKK
101-150101IKSPSKLSPK111AKKIYNEFIS121VQATKEVNLD131SCTREETSRN141MLEPTITCFD
151-200151EAQKKIFNLM161EKDSYRRFLK171SRFYLDLVNP181SSCGAEKQKG191AKSSADCASL
201-205201VPQCA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
2 DBPTM SWISSPALM - - -
GPS-Palm: 0.96
Deep-Palm: 0.06
12 DBPTM SWISSPALM - - -
GPS-Palm: 0.97
Deep-Palm: 0.56
33 - - -
Deep-Palm: 0.38
48 RGS, subdomain 1/3 - -
GPS-Palm: 0.77
Deep-Palm: 0.47
71 - - -
Deep-Palm: 0.86
95 DBPTM Regulator of G protein signaling domain - -
GPS-Palm: 0.86
Deep-Palm: 0.84
132 - - -
GPS-Palm: 0.72
Deep-Palm: 0.70
148 - - -
GPS-Palm: 0.84
Deep-Palm: 0.75
183 - - -
GPS-Palm: 0.86
Deep-Palm: 0.93
197 - - -
GPS-Palm: 0.90
Deep-Palm: 0.05
204 - - -
GPS-Palm: 0.97
Deep-Palm: 0.02
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
11 S → C 0.001969 SNP Missense Mutation HNSC
37 S → C 0.001887 SNP Missense Mutation UCEC
105 S → C 0.002033 SNP Missense Mutation LUSC
131 S → C 0.002294 SNP Missense Mutation OV
132 C → Y 0.002545 SNP Missense Mutation GBM
166 R → C 0.002294 SNP Missense Mutation OV
166 R → C 0.002545 SNP Missense Mutation GBM
204* C → ? 0.001014 SNP Nonsense Mutation BRCA
? ? → ? 0.001764 SNP Missense Mutation LUAD