Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P49841 | GSK3B | Glycogen synthase kinase-3 beta (GSK-3 … | Homo sapiens (Human) | 420 aa |
Protein Details: P49841 (GSK3B)
Protein Information
| Accession | P49841 |
|---|---|
| Protein Names | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) |
| Gene Symbol | GSK3B |
| Organism | Homo sapiens (Human) |
| Length | 420 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | PTMDSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSGRPRTTSF11AESCKPVQQP21SAFGSMKVSR31DKDGSKVTTV41VATPGQGPDR
51-10051PQEVSYTDTK61VIGNGSFGVV71YQAKLCDSGE81LVAIKKVLQD91KRFKNRELQI
101-150101MRKLDHCNIV111RLRYFFYSSG121EKKDEVYLNL131VLDYVPETVY141RVARHYSRAK
151-200151QTLPVIYVKL161YMYQLFRSLA171YIHSFGICHR181DIKPQNLLLD191PDTAVLKLCD
201-250201FGSAKQLVRG211EPNVSYICSR221YYRAPELIFG231ATDYTSSIDV241WSAGCVLAEL
251-300251LLGQPIFPGD261SGVDQLVEII271KVLGTPTREQ281IREMNPNYTE291FKFPQIKAHP
301-350301WTKVFRPRTP311PEAIALCSRL321LEYTPTARLT331PLEACAHSFF341DELRDPNVKL
351-400351PNGRDTPALF361NFTTQELSSN371PPLATILIPP381HARIQAAAST391PTNATAASDA
401-420401NTGDRGQTNN411AASASASNST
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 14 | PTMD SWISSPALM | - | - | - |
Deep-Palm: 0.43
|
| 76 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.88
|
|
| 107 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.33
|
|
| 178 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.30
|
|
| 199 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.98
|
|
| 218 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.92
|
|
| 245 | - | - | - |
Deep-Palm: 0.71
|
|
| 317 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.94
|
|
| 335 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.63
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 1.000
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 127 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 216 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 199* | C → ? | 0.002141 | SNP | Nonsense Mutation | SKCM |