Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P49914 | MTHFS | 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate … | Homo sapiens (Human) | 203 aa |
Protein Details: P49914 (MTHFS)
Protein Information
| Accession | P49914 |
|---|---|
| Protein Names | 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase) |
| Gene Symbol | MTHFS |
| Organism | Homo sapiens (Human) |
| Length | 203 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAAAVSSAK11RSLRGELKQR21LRAMSAEERL31RQSRVLSQKV41IAHSEYQKSK
51-10051RISIFLSMQD61EIETEEIIKD71IFQRGKICFI81PRYRFQSNHM91DMVRIESPEE
101-150101ISLLPKTSWN111IPQPGEGDVR121EEALSTGGLD131LIFMPGLGFD141KHGNRLGRGK
151-200151GYYDAYLKRC161LQHQEVKPYT171LALAFKEQIC181LQVPVNENDM191KVDEVLYEDS
201-203201STA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 78 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.14
|
|
| 160 | - | - | - |
Deep-Palm: 0.96
|
|
| 180 | - | - | - |
Deep-Palm: 0.85
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
HAP1 cell
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 78 | C → C | 0.001014 | SNP | Silent | BRCA |
| 152 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 159 | R → C | 0.002506 | SNP | Missense Mutation | COAD |