Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P50148 | GNAQ | Guanine nucleotide-binding protein G(q) subunit … | Homo sapiens (Human) | 359 aa |
Protein Details: P50148 (GNAQ)
Protein Information
| Accession | P50148 |
|---|---|
| Protein Names | Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) |
| Gene Symbol | GNAQ |
| Organism | Homo sapiens (Human) |
| Length | 359 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 24357059 26111759 26876311 29575903 29733200 32651440 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTLESIMACC11LSEEAKEARR21INDEIERQLR31RDKRDARREL41KLLLLGTGES
51-10051GKSTFIKQMR61IIHGSGYSDE71DKRGFTKLVY81QNIFTAMQAM91IRAMDTLKIP
101-150101YKYEHNKAHA111QLVREVDVEK121VSAFENPYVD131AIKSLWNDPG141IQECYDRRRE
151-200151YQLSDSTKYY161LNDLDRVADP171AYLPTQQDVL181RVRVPTTGII191EYPFDLQSVI
201-250201FRMVDVGGQR211SERRKWIHCF221ENVTSIMFLV231ALSEYDQVLV241ESDNENRMEE
251-300251SKALFRTIIT261YPWFQNSSVI271LFLNKKDLLE281EKIMYSHLVD291YFPEYDGPQR
301-350301DAQAAREFIL311KMFVDLNPDS321DKIIYSHFTC331ATDTENIRFV341FAAVKDTILQ
351-359351LNLKEYNLV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 9 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.03
|
| 10 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.04
|
| 144 | SWISSPALM DBPTM CYSMODDB | G-protein alpha subunit |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.80
Deep-Palm: 0.66
|
| 219 | - | - | - |
Deep-Palm: 0.76
|
|
| 330 | - | - | - |
Deep-Palm: 0.17
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.300
6
Jurkat T cell
Specificity: 0.261
6/6 (100.0%)
4
Primary T cell
Specificity: 0.174
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.174
4/4 (100.0%)
1
HAP1 cell
Specificity: 0.043
1/1 (100.0%)
1
HeLa cell
Specificity: 0.043
1/1 (100.0%)
1
EC cell
Specificity: 0.043
1/1 (100.0%)
1
frontal cortex
Specificity: 0.043
1/1 (100.0%)
1
heart
Specificity: 0.043
1/1 (100.0%)
1
HUVECs
Specificity: 0.043
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.130
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 10 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 356 | Y → C | 0.002141 | SNP | Missense Mutation | SKCM |