Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P50281 MMP14 Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) … Homo sapiens (Human) 582 aa

Protein Details: P50281 (MMP14)

Protein Information
AccessionP50281
Protein NamesMatrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Gene SymbolMMP14
OrganismHomo sapiens (Human)
Length582 aa
IsoformsNo isoforms
Related PMIDs 19801377 22496122 24357059
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MSPAPRPPRC11LLLPLLTLGT21ALASLGSAQS31SSFSPEAWLQ41QYGYLPPGDL
51-10051RTHTQRSPQS61LSAAIAAMQK71FYGLQVTGKA81DADTMKAMRR91PRCGVPDKFG
101-150101AEIKANVRRK111RYAIQGLKWQ121HNEITFCIQN131YTPKVGEYAT141YEAIRKAFRV
151-200151WESATPLRFR161EVPYAYIREG171HEKQADIMIF181FAEGFHGDST191PFDGEGGFLA
201-250201HAYFPGPNIG211GDTHFDSAEP221WTVRNEDLNG231NDIFLVAVHE241LGHALGLEHS
251-300251SDPSAIMAPF261YQWMDTENFV271LPDDDRRGIQ281QLYGGESGFP291TKMPPQPRTT
301-350301SRPSVPDKPK311NPTYGPNICD321GNFDTVAMLR331GEMFVFKERW341FWRVRNNQVM
351-400351DGYPMPIGQF361WRGLPASINT371AYERKDGKFV381FFKGDKHWVF391DEASLEPGYP
401-450401KHIKELGRGL411PTDKIDAALF421WMPNGKTYFF431RGNKYYRFNE441ELRAVDSEYP
451-500451KNIKVWEGIP461ESPRGSFMGS471DEVFTYFYKG481NKYWKFNNQK491LKVEPGYPKS
501-550501ALRDWMGCPS511GGRPDEGTEE521ETEVIIIEVD531EEGGGAVSAA541AVVLPVLLLL
551-582551LVLAVGLAVF561FFRRHGTPRR571LLYCQRSLLD581KV
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
10 - - -
GPS-Palm: 0.71
Deep-Palm: 0.92
93 - - -
GPS-Palm: 0.87
Deep-Palm: 0.93
127 - - -
Deep-Palm: 0.08
319 - - -
Deep-Palm: 0.22
508 - - -
GPS-Palm: 0.82
Deep-Palm: 0.88
574 DBPTM SWISSPALM Domain of unknown function (DUF3377) - -
GPS-Palm: 0.95
Deep-Palm: 0.14
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
1
EC cell
Specificity: 0.333
1/1 (100.0%)
1
HUVECs
Specificity: 0.333
1/1 (100.0%)
1
DU145 cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
10 C → R 0.002545 SNP Missense Mutation GBM
145 R → C 0.002506 SNP Missense Mutation COAD
149 R → C 0.002506 SNP Missense Mutation COAD
160 R → C 0.002545 SNP Missense Mutation GBM
206 G → C 0.002033 SNP Missense Mutation LUSC
283 Y → C 0.002288 SNP Missense Mutation STAD
339 R → C 0.001887 SNP Missense Mutation UCEC
431 R → C 0.007299 SNP Missense Mutation READ
431 R → C 0.001887 SNP Missense Mutation UCEC
478 Y → C 0.001887 SNP Missense Mutation UCEC
576 R → C 0.001887 SNP Missense Mutation UCEC