Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P50281 MMP14 Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) … Homo sapiens (Human) 582 aa

Protein Details: P50281 (MMP14)

Protein Information
Accession P50281
Protein Names Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Gene Symbol MMP14
Organism Homo sapiens (Human)
Length 582 aa
Isoforms No isoforms
Related PMIDs 19801377 22496122 24357059 32944167
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
4
PC3 cells
Specificity: 0.500
4/4 (100.0%)
2
DU145 cells
Specificity: 0.250
2/2 (100.0%)
2
Endothelial cells
Specificity: 0.250
2/2 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSPAPRPPRC11LLLPLLTLGT21ALASLGSAQS31SSFSPEAWLQ41QYGYLPPGDL
51-10051RTHTQRSPQS61LSAAIAAMQK71FYGLQVTGKA81DADTMKAMRR91PRCGVPDKFG
101-150101AEIKANVRRK111RYAIQGLKWQ121HNEITFCIQN131YTPKVGEYAT141YEAIRKAFRV
151-200151WESATPLRFR161EVPYAYIREG171HEKQADIMIF181FAEGFHGDST191PFDGEGGFLA
201-250201HAYFPGPNIG211GDTHFDSAEP221WTVRNEDLNG231NDIFLVAVHE241LGHALGLEHS
251-300251SDPSAIMAPF261YQWMDTENFV271LPDDDRRGIQ281QLYGGESGFP291TKMPPQPRTT
301-350301SRPSVPDKPK311NPTYGPNICD321GNFDTVAMLR331GEMFVFKERW341FWRVRNNQVM
351-400351DGYPMPIGQF361WRGLPASINT371AYERKDGKFV381FFKGDKHWVF391DEASLEPGYP
401-450401KHIKELGRGL411PTDKIDAALF421WMPNGKTYFF431RGNKYYRFNE441ELRAVDSEYP
451-500451KNIKVWEGIP461ESPRGSFMGS471DEVFTYFYKG481NKYWKFNNQK491LKVEPGYPKS
501-550501ALRDWMGCPS511GGRPDEGTEE521ETEVIIIEVD531EEGGGAVSAA541AVVLPVLLLL
551-582551LVLAVGLAVF561FFRRHGTPRR571LLYCQRSLLD581KV
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
10 Prediction (Low) - -
93 Prediction (Medium) - -
508 Prediction (Medium) - -
574 Experimental DBPTM SWISSPALM Prediction (High) Domain of unknown function (DUF3377) 19801377
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
10 C → R 0.002545 SNP Missense Mutation GBM
145 R → C 0.002506 SNP Missense Mutation COAD
149 R → C 0.002506 SNP Missense Mutation COAD
160 R → C 0.002545 SNP Missense Mutation GBM
206 G → C 0.002033 SNP Missense Mutation LUSC
283 Y → C 0.002288 SNP Missense Mutation STAD
339 R → C 0.001887 SNP Missense Mutation UCEC
431 R → C 0.007299 SNP Missense Mutation READ
431 R → C 0.001887 SNP Missense Mutation UCEC
478 Y → C 0.001887 SNP Missense Mutation UCEC
576 R → C 0.001887 SNP Missense Mutation UCEC