Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P50416-2 | CPT1A | Carnitine O-palmitoyltransferase 1, liver isoform … | Homo sapiens (Human) | 756 aa |
Protein Details: P50416-2 (CPT1A)
Protein Information
| Accession | P50416-2 |
|---|---|
| Protein Names | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-) |
| Gene Symbol | CPT1A |
| Organism | Homo sapiens (Human) |
| Length | 756 aa |
| Isoforms | |
| Related PMIDs | 31251020 33636221 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAEAHQAVAF11QFTVTPDGID21LRLSHEALRQ31IYLSGLHSWK41KKFIRFKNGI
51-10051ITGVYPASPS61SWLIVVVGVM71TTMYAKIDPS81LGIIAKINRT91LETANCMSSQ
101-150101TKNVVSGVLF111GTGLWVALIV121TMRYSLKVLL131SYHGWMFTEH141GKMSRATKIW
151-200151MGMVKIFSGR161KPMLYSFQTS171LPRLPVPAVK181DTVNRYLQSV191RPLMKEEDFK
201-250201RMTALAQDFA211VGLGPRLQWY221LKLKSWWATN231YVSDWWEEYI241YLRGRGPLMV
251-300251NSNYYAMDLL261YILPTHIQAA271RAGNAIHAIL281LYRRKLDREE291IKPIRLLGST
301-350301IPLCSAQWER311MFNTSRIPGE321ETDTIQHMRD331SKHIVVYHRG341RYFKVWLYHD
351-400351GRLLKPREME361QQMQRILDNT371SEPQPGEARL381AALTAGDRVP391WARCRQAYFG
401-450401RGKNKQSLDA411VEKAAFFVTL421DETEEGYRSE431DPDTSMDSYA441KSLLHGRCYD
451-500451RWFDKSFTFV461VFKNGKMGLN471AEHSWADAPI481VAHLWEYVMS491IDSLQLGYAE
501-550501DGHCKGDINP511NIPYPTRLQW521DIPGECQEVI531ETSLNTANLL541ANDVDFHSFP
551-600551FVAFGKGIIK561KCRTSPDAFV571QLALQLAHYK581DMGKFCLTYE591ASMTRLFREG
601-650601RTETVRSCTT611ESCDFVRAMV621DPAQTVEQRL631KLFKLASEKH641QHMYRLAMTG
651-700651SGIDRHLFCL661YVVSKYLAVE671SPFLKEVLSE681PWRLSTSQTP691QQQVELFDLE
701-750701NNPEYVSSGG711GFGPVADDGY721GVSYILVGEN731LINFHISSKF741SCPETGIISQ
751-756751GPSSDT
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 96 | - | - | - |
Deep-Palm: 0.84
|
|
| 304 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.84
|
|
| 394 | - | - | - |
Deep-Palm: 0.97
|
|
| 448 | - | - | - |
Deep-Palm: 0.34
|
|
| 504 | - | - | - |
Deep-Palm: 0.40
|
|
| 526 | - | - | - |
Deep-Palm: 0.76
|
|
| 562 | - | - | - |
Deep-Palm: 0.77
|
|
| 586 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.90
|
|
| 608 | - | - | - |
Deep-Palm: 0.82
|
|
| 613 | - | - | - |
Deep-Palm: 0.54
|
|
| 659 | - | - | - |
Deep-Palm: 0.82
|
|
| 742 | - | - | - |
Deep-Palm: 0.75
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
LNCaP
Specificity: 0.500
4/4 (100.0%)
3
cerebral cortex
Specificity: 0.375
3/3 (100.0%)
1
heart
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 46 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 123 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 498 | Y → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 585 | F → C | 0.002294 | SNP | Missense Mutation | OV |
| 645 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 655 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 749 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |