Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P50993 | ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) … | Homo sapiens (Human) | 1020 aa |
Protein Details: P50993 (ATP1A2)
Protein Information
| Accession | P50993 |
|---|---|
| Protein Names | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) |
| Gene Symbol | ATP1A2 |
| Organism | Homo sapiens (Human) |
| Length | 1020 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGRGAGREYS11PAATTAENGG21GKKKQKEKEL31DELKKEVAMD41DHKLSLDELG
51-10051RKYQVDLSKG61LTNQRAQDVL71ARDGPNALTP81PPTTPEWVKF91CRQLFGGFSI
101-150101LLWIGAILCF111LAYGIQAAME121DEPSNDNLYL131GVVLAAVVIV141TGCFSYYQEA
151-200151KSSKIMDSFK161NMVPQQALVI171REGEKMQINA181EEVVVGDLVE191VKGGDRVPAD
201-250201LRIISSHGCK211VDNSSLTGES221EPQTRSPEFT231HENPLETRNI241CFFSTNCVEG
251-300251TARGIVIATG261DRTVMGRIAT271LASGLEVGRT281PIAMEIEHFI291QLITGVAVFL
301-350301GVSFFVLSLI311LGYSWLEAVI321FLIGIIVANV331PEGLLATVTV341CLTLTAKRMA
351-400351RKNCLVKNLE361AVETLGSTST371ICSDKTGTLT381QNRMTVAHMW391FDNQIHEADT
401-450401TEDQSGATFD411KRSPTWTALS421RIAGLCNRAV431FKAGQENISV441SKRDTAGDAS
451-500451ESALLKCIEL461SCGSVRKMRD471RNPKVAEIPF481NSTNKYQLSI491HEREDSPQSH
501-550501VLVMKGAPER511ILDRCSTILV521QGKEIPLDKE531MQDAFQNAYM541ELGGLGERVL
551-600551GFCQLNLPSG561KFPRGFKFDT571DELNFPTEKL581CFVGLMSMID591PPRAAVPDAV
601-650601GKCRSAGIKV611IMVTGDHPIT621AKAIAKGVGI631ISEGNETVED641IAARLNIPMS
651-700651QVNPREAKAC661VVHGSDLKDM671TSEQLDEILK681NHTEIVFART691SPQQKLIIVE
701-750701GCQRQGAIVA711VTGDGVNDSP721ALKKADIGIA731MGISGSDVSK741QAADMILLDD
751-800751NFASIVTGVE761EGRLIFDNLK771KSIAYTLTSN781IPEITPFLLF791IIANIPLPLG
801-850801TVTILCIDLG811TDMVPAISLA821YEAAESDIMK831RQPRNSQTDK841LVNERLISMA
851-900851YGQIGMIQAL861GGFFTYFVIL871AENGFLPSRL881LGIRLDWDDR891TMNDLEDSYG
901-950901QEWTYEQRKV911VEFTCHTAFF921ASIVVVQWAD931LIICKTRRNS941VFQQGMKNKI
951-1000951LIFGLLEETA961LAAFLSYCPG971MGVALRMYPL981KVTWWFCAFP991YSLLIFIYDE
1001-10201001VRKLILRRYP1011GGWVEKETYY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 91 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.88
|
|
| 109 | - | - | - |
Deep-Palm: 0.66
|
|
| 143 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.92
|
|
| 209 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.96
|
|
| 241 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.45
|
|
| 247 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.91
|
|
| 341 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.97
|
|
| 354 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.96
|
|
| 372 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.76
Deep-Palm: 0.98
|
|
| 426 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.87
Deep-Palm: 0.95
|
|
| 457 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.67
Deep-Palm: 0.95
|
|
| 462 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.96
|
|
| 515 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.79
Deep-Palm: 0.98
|
|
| 553 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.96
|
|
| 581 | - | - | - |
Deep-Palm: 0.57
|
|
| 603 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.96
|
|
| 660 | SWISSPALM DBPTM CYSMODDB | - |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.80
Deep-Palm: 0.89
|
| 702 | SWISSPALM DBPTM CYSMODDB | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.90
|
| 806 | - | - | - |
Deep-Palm: 0.97
|
|
| 915 | - | - | - |
Deep-Palm: 0.09
|
|
| 934 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.58
|
|
| 968 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.98
|
|
| 987 | - | - | - |
Deep-Palm: 0.36
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
3
LNCaP
Specificity: 0.231
3/3 (100.0%)
1
HeLa cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.077
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 51 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 143 | C → G | 0.002506 | SNP | Missense Mutation | COAD |
| 247 | C → C | 0.002033 | SNP | Silent | LUSC |
| 267 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 267 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 428 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 486 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 510 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 548 | R → C | 0.002976 | SNP | Missense Mutation | KIRC |
| 664 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 861 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 861 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 976 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |