Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P50993 | ATP1A2; KIAA0778 | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) … | Homo sapiens (Human) | 1020 aa |
Protein Details: P50993 (ATP1A2)
Protein Information
| Accession | P50993 |
|---|---|
| Protein Names | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) |
| Gene Symbol | ATP1A2; KIAA0778 |
| Organism | Homo sapiens (Human) |
| Length | 1020 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29575903 31251020 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.837
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.837
36/46 (78.3%)
4
Cerebral cortex
Specificity: 0.093
4/4 (100.0%)
2
Jurkat T cells
Specificity: 0.047
2/25 (8.0%)
1
HeLa cells
Specificity: 0.023
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGRGAGREYS11PAATTAENGG21GKKKQKEKEL31DELKKEVAMD41DHKLSLDELG
51-10051RKYQVDLSKG61LTNQRAQDVL71ARDGPNALTP81PPTTPEWVKF91CRQLFGGFSI
101-150101LLWIGAILCF111LAYGIQAAME121DEPSNDNLYL131GVVLAAVVIV141TGCFSYYQEA
151-200151KSSKIMDSFK161NMVPQQALVI171REGEKMQINA181EEVVVGDLVE191VKGGDRVPAD
201-250201LRIISSHGCK211VDNSSLTGES221EPQTRSPEFT231HENPLETRNI241CFFSTNCVEG
251-300251TARGIVIATG261DRTVMGRIAT271LASGLEVGRT281PIAMEIEHFI291QLITGVAVFL
301-350301GVSFFVLSLI311LGYSWLEAVI321FLIGIIVANV331PEGLLATVTV341CLTLTAKRMA
351-400351RKNCLVKNLE361AVETLGSTST371ICSDKTGTLT381QNRMTVAHMW391FDNQIHEADT
401-450401TEDQSGATFD411KRSPTWTALS421RIAGLCNRAV431FKAGQENISV441SKRDTAGDAS
451-500451ESALLKCIEL461SCGSVRKMRD471RNPKVAEIPF481NSTNKYQLSI491HEREDSPQSH
501-550501VLVMKGAPER511ILDRCSTILV521QGKEIPLDKE531MQDAFQNAYM541ELGGLGERVL
551-600551GFCQLNLPSG561KFPRGFKFDT571DELNFPTEKL581CFVGLMSMID591PPRAAVPDAV
601-650601GKCRSAGIKV611IMVTGDHPIT621AKAIAKGVGI631ISEGNETVED641IAARLNIPMS
651-700651QVNPREAKAC661VVHGSDLKDM671TSEQLDEILK681NHTEIVFART691SPQQKLIIVE
701-750701GCQRQGAIVA711VTGDGVNDSP721ALKKADIGIA731MGISGSDVSK741QAADMILLDD
751-800751NFASIVTGVE761EGRLIFDNLK771KSIAYTLTSN781IPEITPFLLF791IIANIPLPLG
801-850801TVTILCIDLG811TDMVPAISLA821YEAAESDIMK831RQPRNSQTDK841LVNERLISMA
851-900851YGQIGMIQAL861GGFFTYFVIL871AENGFLPSRL881LGIRLDWDDR891TMNDLEDSYG
901-950901QEWTYEQRKV911VEFTCHTAFF921ASIVVVQWAD931LIICKTRRNS941VFQQGMKNKI
951-1000951LIFGLLEETA961LAAFLSYCPG971MGVALRMYPL981KVTWWFCAFP991YSLLIFIYDE
1001-10201001VRKLILRRYP1011GGWVEKETYY
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 91 | Prediction (Low) | - | - |
| 143 | Prediction (Medium) | - | - |
| 209 | Prediction (Low) | - | - |
| 341 | Prediction (Medium) | - | - |
| 354 | Prediction (High) | - | - |
| 372 | Prediction (Low) | - | - |
| 426 | Prediction (Medium) | - | - |
| 457 | Prediction (Low) | - | - |
| 462 | Prediction (High) | - | - |
| 515 | Prediction (Medium) | - | - |
| 553 | Prediction (Medium) | - | - |
| 603 | Prediction (Medium) | - | - |
| 660 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | - |
| 702 | CYSMODDB SWISSPALM DBPTM Prediction (High) | - | - |
| 934 | Prediction (High) | - | - |
| 968 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 51 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 143 | C → G | 0.002506 | SNP | Missense Mutation | COAD |
| 247 | C → C | 0.002033 | SNP | Silent | LUSC |
| 267 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 267 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 428 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 486 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 510 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 548 | R → C | 0.002976 | SNP | Missense Mutation | KIRC |
| 664 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 861 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 861 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 976 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |