Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P51149 | RAB7A | Ras-related protein Rab-7a (EC 3.6.5.2) | Homo sapiens (Human) | 207 aa |
Protein Details: P51149 (RAB7A)
Protein Information
| Accession | P51149 |
|---|---|
| Protein Names | Ras-related protein Rab-7a (EC 3.6.5.2) |
| Gene Symbol | RAB7A |
| Organism | Homo sapiens (Human) |
| Length | 207 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 29733200 31251020 31382980 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | PTMDSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTSRKKVLLK11VIILGDSGVG21KTSLMNQYVN31KKFSNQYKAT41IGADFLTKEV
51-10051MVDDRLVTMQ61IWDTAGQERF71QSLGVAFYRG81ADCCVLVFDV91TAPNTFKTLD
101-150101SWRDEFLIQA111SPRDPENFPF121VVLGNKIDLE131NRQVATKRAQ141AWCYSKNNIP
151-200151YFETSAKEAI161NVEQAFQTIA171RNALKQETEV181ELYNEFPEPI191KLDKNDRAKA
201-207201SAESCSC
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 83 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.82
Deep-Palm: 0.83
|
|
| 84 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.73
Deep-Palm: 0.82
|
|
| 143 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.92
|
|
| 205 | SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.04
|
| 207 | SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.273
3
cerebral cortex
Specificity: 0.214
3/3 (100.0%)
2
LNCaP
Specificity: 0.143
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.143
2/2 (100.0%)
2
293T cell
Specificity: 0.143
2/2 (100.0%)
1
U937 cell
Specificity: 0.071
1/1 (100.0%)
1
frontal cortex
Specificity: 0.071
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.214
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 84 | C → C | 0.007299 | SNP | Silent | READ |
| 96 | F → C | 0.002506 | SNP | Missense Mutation | COAD |