Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P51660 Hsd17b4 Peroxisomal multifunctional enzyme type 2 … Mus musculus (Mouse) 735 aa

Protein Details: P51660 (Hsd17b4)

Protein Information
AccessionP51660
Protein NamesPeroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]
Gene SymbolHsd17b4
OrganismMus musculus (Mouse)
Length735 aa
IsoformsNo isoforms
Related PMIDs 28526873 31311849 34200797 34884899 35358180 35477839 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MASPLRFDGR11VVLVTGAGGG21LGRAYALAFA31ERGALVIVND41LGGDFKGIGK
51-10051GSSAADKVVA61EIRRKGGKAV71ANYDSVEAGE81KLVKTALDTF91GRIDVVVNNA
101-150101GILRDRSFSR111ISDEDWDIIH121RVHLRGSFQV131TRAAWDHMKK141QNYGRILMTS
151-200151SASGIYGNFG161QANYSAAKLG171ILGLCNTLAI181EGRKNNIHCN191TIAPNAGSRM
201-250201TETVLPEDLV211EALKPEYVAP221LVLWLCHESC231EENGGLFEVG241AGWIGKLRWE
251-300251RTLGAIVRKR261NQPMTPEAVR271DNWEKICDFS281NASKPQTIQE291STGGIVEVLH
301-350301KVDSEGISPN311RTSHAAPAAT321SGFVGAVGHK331LPSFSSSYTE341LQSIMYALGV
351-400351GASVKNPKDL361KFVYEGSADF371SCLPTFGVIV381AQKSMMNGGL391AEVPGLSFNF
401-450401AKALHGEQYL411ELYKPLPRSG421ELKCEAVIAD431ILDKGSGVVI441VMDVYSYSGK
451-500451ELICYNQFSV461FVVGSGGFGG471KRTSEKLKAA481VAVPNRPPDA491VLRDATSLNQ
501-550501AALYRLSGDW511NPLHIDPDFA521SVAGFEKPIL531HGLCTFGFSA541RHVLQQFADN
551-600551DVSRFKAIKV561RFAKPVYPGQ571TLQTEMWKEG581NRIHFQTKVH591ETGDVVISNA
601-650601YVDLVPASGV611STQTPSEGGE621LQSALVFGEI631GRRLKSVGRE641VVKKANAVFE
651-700651WHITKGGTVA661AKWTIDLKSG671SGEVYQGPAK681GSADVTIIIS691DEDFMEVVFG
701-735701KLDPQKAFFS711GRLKARGNIM721LSQKLQMILK731DYAKL
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
175 SWISSPALM DBPTM CYSMODDB short chain dehydrogenase
Liver (28526873)
Brain (31311849)
Liver (34884899)
Brain (31311849)
GPS-Palm: 0.95
Deep-Palm: 0.97
189 SWISSPALM DBPTM CYSMODDB -
Brain (31311849)
liver (26165157)
Liver (37925639)
Brain (31311849)
GPS-Palm: 0.85
Deep-Palm: 0.90
226 - - -
Deep-Palm: 0.98
230 - - -
Deep-Palm: 0.95
277 SWISSPALM DBPTM CYSMODDB -
Liver (28526873)
Brain (31311849)
liver (26165157)
Brain (31311849)
GPS-Palm: 0.83
Deep-Palm: 0.41
372 - - -
Deep-Palm: 0.89
424 - - -
GPS-Palm: 0.78
Deep-Palm: 0.98
454 - - -
Deep-Palm: 0.37
534 - - -
GPS-Palm: 0.76
Deep-Palm: 0.87
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.545
6
Liver
Specificity: 0.353
6/6 (100.0%)
3
Brain
Specificity: 0.176
3/3 (100.0%)
2
Testis
Specificity: 0.118
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
Brain tissue (Mass)
Specificity: 0.235
4/56 (7.1%)
2
Liver tissue (Mass)
Specificity: 0.118
2/8 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine