Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P52907 | CAPZA1 | F-actin-capping protein subunit alpha-1 (CapZ … | Homo sapiens (Human) | 286 aa |
Protein Details: P52907 (CAPZA1)
Protein Information
| Accession | P52907 |
|---|---|
| Protein Names | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) |
| Gene Symbol | CAPZA1 |
| Organism | Homo sapiens (Human) |
| Length | 286 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MADFDDRVSD11EEKVRIAAKF21ITHAPPGEFN31EVFNDVRLLL41NNDNLLREGA
51-10051AHAFAQYNMD61QFTPVKIEGY71EDQVLITEHG81DLGNSRFLDP91RNKISFKFDH
101-150101LRKEASDPQP111EEADGGLKSW121RESCDSALRA131YVKDHYSNGF141CTVYAKTIDG
151-200151QQTIIACIES161HQFQPKNFWN171GRWRSEWKFT181ITPPTAQVVG191VLKIQVHYYE
201-250201DGNVQLVSHK211DVQDSLTVSN221EAQTAKEFIK231IIENAENEYQ241TAISENYQTM
251-286251SDTTFKALRR261QLPVTRTKID271WNKILSYKIG281KEMQNA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 124 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.90
|
|
| 141 | - | - | - |
Deep-Palm: 0.60
|
|
| 157 | SWISSPALM DBPTM CYSMODDB | F-actin capping protein alpha subunit | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.28
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.267
4/4 (100.0%)
3
cerebral cortex
Specificity: 0.200
3/3 (100.0%)
1
LNCaP
Specificity: 0.067
1/1 (100.0%)
1
HAP1 cell
Specificity: 0.067
1/1 (100.0%)
1
293T cell
Specificity: 0.067
1/1 (100.0%)
1
heart
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 29 | F → C | 0.003460 | SNP | Missense Mutation | CESC |
| 87 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 172 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| ? | ? → ? | 0.005618 | SNP | Missense Mutation | PAAD |