Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P54869 Hmgcs2 Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) … Mus musculus (Mouse) 508 aa

Protein Details: P54869 (Hmgcs2)

Protein Information
AccessionP54869
Protein NamesHydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)
Gene SymbolHmgcs2
OrganismMus musculus (Mouse)
Length508 aa
IsoformsNo isoforms
Related PMIDs 28526873 29660268 34884899 35477839 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MQRLLAPARR11VLQVKRAMQE21TSLTPAHLLS31AAQQRFSTIP41PAPLAKTDTW
51-10051PKDVGILALE61VYFPAQYVDQ71TDLEKFNNVE81AGKYTVGLGQ91TRMGFCSVQE
101-150101DINSLCLTVV111QRLMERTKLP121WDAVGRLEVG131TETIIDKSKA141VKTVLMELFQ
151-200151DSGNTDIEGI161DTTNACYGGT171ASLFNAANWM181ESSYWDGRYA191LVVCGDIAVY
201-250201PSGNARPTGG211AGAVAMLIGP221KAPLVLEQGL231RGTHMENAYD241FYKPNLASEY
251-300251PLVDGKLSIQ261CYLRALDRCY271AAYRKKIQNQ281WKQAGNNQPF291TLDDVQYMIF
301-350301HTPFCKMVQK311SLARLMFNDF321LSSSSDKQNN331LYKGLEAFRG341LKLEETYTNK
351-400351DVDKALLKAS361LDMFNQKTKA371SLYLSTNNGN381MYTSSLYGCL391ASLLSHHSAQ
401-450401ELAGSRIGAF411SYGSGLAASF421FSFRVSKDAS431PGSPLEKLVS441SVSDLPKRLD
451-500451SRRRMSPEEF461TEIMNQREQF471YHKVNFSPPG481DTSNLFPGTW491YLERVDEMHR
501-508501RKYARCPV
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
96 SWISSPALM DBPTM CYSMODDB Hydroxymethylglutaryl-coenzyme A synthase N terminal
Liver (28526873)
Liver (37925639)
GPS-Palm: 0.88
Deep-Palm: 0.92
106 SWISSPALM DBPTM CYSMODDB Hydroxymethylglutaryl-coenzyme A synthase N terminal
Liver (28526873)
Liver (37925639)
GPS-Palm: 0.84
Deep-Palm: 0.84
166 - - -
Deep-Palm: 0.62
194 - - -
Deep-Palm: 0.48
261 SWISSPALM DBPTM CYSMODDB Hydroxymethylglutaryl-coenzyme A synthase C terminal
Liver (28526873)
Liver (37925639)
GPS-Palm: 0.77
Deep-Palm: 0.97
269 - - -
GPS-Palm: 0.85
Deep-Palm: 0.89
305 SWISSPALM DBPTM CYSMODDB Hydroxymethylglutaryl-coenzyme A synthase C terminal
Liver (28526873)
-
GPS-Palm: 0.77
Deep-Palm: 0.63
389 SWISSPALM DBPTM CYSMODDB Hydroxymethylglutaryl-coenzyme A synthase C terminal
Liver (28526873)
Liver (34884899)
Deep-Palm: 0.89
506 - - -
GPS-Palm: 0.93
Deep-Palm: 0.03
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
6
Liver
Specificity: 0.400
6/6 (100.0%)
2
Testis
Specificity: 0.133
2/2 (100.0%)
1
Brain
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
6
Liver tissue (Mass)
Specificity: 0.400
6/8 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine