Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P55072 | VCP; HEL-220; HEL-S-70 | Transitional endoplasmic reticulum ATPase (TER … | Homo sapiens (Human) | 806 aa |
Protein Details: P55072 (VCP)
Protein Information
| Accession | P55072 |
|---|---|
| Protein Names | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) |
| Gene Symbol | VCP; HEL-220; HEL-S-70 |
| Organism | Homo sapiens (Human) |
| Length | 806 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29575903 29733200 31251020 31382980 32944167 33636221 36430497 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.545
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.545
36/46 (78.3%)
10
HAP1 cells
Specificity: 0.152
10/10 (100.0%)
6
Jurkat T cells
Specificity: 0.091
6/25 (24.0%)
4
PC3 cells
Specificity: 0.061
4/4 (100.0%)
4
293T cells
Specificity: 0.061
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.061
4/4 (100.0%)
1
U937 cells
Specificity: 0.015
1/1 (100.0%)
1
Liver membrane
Specificity: 0.015
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MASGADSKGD11DLSTAILKQK21NRPNRLIVDE31AINEDNSVVS41LSQPKMDELQ
51-10051LFRGDTVLLK61GKKRREAVCI71VLSDDTCSDE81KIRMNRVVRN91NLRVRLGDVI
101-150101SIQPCPDVKY111GKRIHVLPID121DTVEGITGNL131FEVYLKPYFL141EAYRPIRKGD
151-200151IFLVRGGMRA161VEFKVVETDP171SPYCIVAPDT181VIHCEGEPIK191REDEEESLNE
201-250201VGYDDIGGCR211KQLAQIKEMV221ELPLRHPALF231KAIGVKPPRG241ILLYGPPGTG
251-300251KTLIARAVAN261ETGAFFFLIN271GPEIMSKLAG281ESESNLRKAF291EEAEKNAPAI
301-350301IFIDELDAIA311PKREKTHGEV321ERRIVSQLLT331LMDGLKQRAH341VIVMAATNRP
351-400351NSIDPALRRF361GRFDREVDIG371IPDATGRLEI381LQIHTKNMKL391ADDVDLEQVA
401-450401NETHGHVGAD411LAALCSEAAL421QAIRKKMDLI431DLEDETIDAE441VMNSLAVTMD
451-500451DFRWALSQSN461PSALRETVVE471VPQVTWEDIG481GLEDVKRELQ491ELVQYPVEHP
501-550501DKFLKFGMTP511SKGVLFYGPP521GCGKTLLAKA531IANECQANFI541SIKGPELLTM
551-600551WFGESEANVR561EIFDKARQAA571PCVLFFDELD581SIAKARGGNI591GDGGGAADRV
601-650601INQILTEMDG611MSTKKNVFII621GATNRPDIID631PAILRPGRLD641QLIYIPLPDE
651-700651KSRVAILKAN661LRKSPVAKDV671DLEFLAKMTN681GFSGADLTEI691CQRACKLAIR
701-750701ESIESEIRRE711RERQTNPSAM721EVEEDDPVPE731IRRDHFEEAM741RFARRSVSDN
751-800751DIRKYEMFAQ761TLQQSRGFGS771FRFPSGNQGG781AGPSQGSGGG791TGGSVYTEDN
801-806801DDDLYG
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 69 | Prediction (Medium) | - | - |
| 77 | Prediction (Low) | - | - |
| 105 | Prediction (High) | - | - |
| 184 | Prediction (Low) | - | - |
| 209 | Prediction (Medium) | - | - |
| 415 | Prediction (Medium) | - | - |
| 522 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | ATPase family associated with various cellular activities (AAA) | 29575903, 37611173 |
| 535 | Prediction (Medium) | - | - |
| 572 | Prediction (High) | - | - |
| 691 | CYSMODDB SWISSPALM DBPTM Prediction (High) | AAA+ lid domain | - |
| 695 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 69 | C → C | 0.001887 | SNP | Silent | UCEC |
| 155 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 155 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 495 | Y → C | 0.002545 | SNP | Missense Mutation | GBM |
| 517 | Y → C | 0.004219 | SNP | Missense Mutation | SARC |
| 700 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 732 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 741 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |