Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P55072 | VCP | Transitional endoplasmic reticulum ATPase (TER … | Homo sapiens (Human) | 806 aa |
Protein Details: P55072 (VCP)
Protein Information
| Accession | P55072 |
|---|---|
| Protein Names | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) |
| Gene Symbol | VCP |
| Organism | Homo sapiens (Human) |
| Length | 806 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29733200 31251020 31382980 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASGADSKGD11DLSTAILKQK21NRPNRLIVDE31AINEDNSVVS41LSQPKMDELQ
51-10051LFRGDTVLLK61GKKRREAVCI71VLSDDTCSDE81KIRMNRVVRN91NLRVRLGDVI
101-150101SIQPCPDVKY111GKRIHVLPID121DTVEGITGNL131FEVYLKPYFL141EAYRPIRKGD
151-200151IFLVRGGMRA161VEFKVVETDP171SPYCIVAPDT181VIHCEGEPIK191REDEEESLNE
201-250201VGYDDIGGCR211KQLAQIKEMV221ELPLRHPALF231KAIGVKPPRG241ILLYGPPGTG
251-300251KTLIARAVAN261ETGAFFFLIN271GPEIMSKLAG281ESESNLRKAF291EEAEKNAPAI
301-350301IFIDELDAIA311PKREKTHGEV321ERRIVSQLLT331LMDGLKQRAH341VIVMAATNRP
351-400351NSIDPALRRF361GRFDREVDIG371IPDATGRLEI381LQIHTKNMKL391ADDVDLEQVA
401-450401NETHGHVGAD411LAALCSEAAL421QAIRKKMDLI431DLEDETIDAE441VMNSLAVTMD
451-500451DFRWALSQSN461PSALRETVVE471VPQVTWEDIG481GLEDVKRELQ491ELVQYPVEHP
501-550501DKFLKFGMTP511SKGVLFYGPP521GCGKTLLAKA531IANECQANFI541SIKGPELLTM
551-600551WFGESEANVR561EIFDKARQAA571PCVLFFDELD581SIAKARGGNI591GDGGGAADRV
601-650601INQILTEMDG611MSTKKNVFII621GATNRPDIID631PAILRPGRLD641QLIYIPLPDE
651-700651KSRVAILKAN661LRKSPVAKDV671DLEFLAKMTN681GFSGADLTEI691CQRACKLAIR
701-750701ESIESEIRRE711RERQTNPSAM721EVEEDDPVPE731IRRDHFEEAM741RFARRSVSDN
751-800751DIRKYEMFAQ761TLQQSRGFGS771FRFPSGNQGG781AGPSQGSGGG791TGGSVYTEDN
801-806801DDDLYG
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 69 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.79
Deep-Palm: 0.94
|
|
| 77 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.69
Deep-Palm: 0.81
|
|
| 105 | - |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.91
|
|
| 174 | - | - | - |
Deep-Palm: 0.46
|
|
| 184 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.75
|
|
| 209 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.83
|
|
| 415 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 522 | SWISSPALM DBPTM CYSMODDB | ATPase family associated with various cellular activities (AAA) |
HeLa
(37611173)
| - |
GPS-Palm: 0.94
Deep-Palm: 0.97
|
| 535 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.98
|
|
| 572 | - |
SW480 cell line
(26865113)
|
Unknown
(32651440)
|
GPS-Palm: 0.92
Deep-Palm: 0.97
|
|
| 691 | SWISSPALM DBPTM CYSMODDB | AAA+ lid domain |
SW480 cell line
(26865113)
|
Unknown
(32651440)
|
GPS-Palm: 0.94
Deep-Palm: 0.96
|
| 695 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.308
4
cerebral cortex
Specificity: 0.235
4/4 (100.0%)
3
LNCaP
Specificity: 0.176
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.118
2/2 (100.0%)
1
U937 cell
Specificity: 0.059
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.059
1/1 (100.0%)
1
293T cell
Specificity: 0.059
1/1 (100.0%)
1
heart
Specificity: 0.059
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.235
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 69 | C → C | 0.001887 | SNP | Silent | UCEC |
| 155 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 155 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 495 | Y → C | 0.002545 | SNP | Missense Mutation | GBM |
| 517 | Y → C | 0.004219 | SNP | Missense Mutation | SARC |
| 700 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 732 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 741 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |